PMID- 33031605
OWN - NLM
STAT- MEDLINE
DCOM- 20210726
LR  - 20210726
IS  - 1439-0507 (Electronic)
IS  - 0933-7407 (Linking)
VI  - 64
IP  - 2
DP  - 2021 Feb
TI  - Oral Paracoccidioidomycosis affecting women: A systematic review.
PG  - 108-122
LID - 10.1111/myc.13194 [doi]
AB  - Paracoccidioidomycosis (PCM) is an infection caused by fungi of the genus 
      Paracoccidioides and is marked by a strong predilection for men; nevertheless, 
      some women have had developed PCM and have presented oral involvement by the 
      disease. OBJECTIVES: To review all published cases until August 2020 of oral PCM 
      in women, with emphasis on the presence of systemic changes, deleterious habits 
      (tobacco and alcohol) and oral manifestation features through a systematic 
      review. METHODS: Observational studies (both prospective and retrospective) and 
      case reports indexed in the Embase, PubMed, Scopus, Web of Science and LIVIVO 
      databases were selected by two reviewers in a two-phase process following the 
      pre-established PICOS criteria. RESULTS: Twenty-five studies met the eligibility 
      criteria and were selected for qualitative synthesis, of which 72 participants 
      were enrolled. Brazilian White women between 40 and 50 years were the most 
      affected and social history revealed them to be housewives or rural workers. 
      Fifteen women (33.3% of the informed cases) presented any systemic change at the 
      time of PCM diagnosis, namely pregnancy, HIV infection and/or depression. 
      Moriform stomatitis was predominant and affected preferentially the gingivae and 
      alveolar processes in the form of a single painful lesion. Most patients were 
      treated with sulfamethoxazole + trimethoprim or itraconazole. CONCLUSIONS: Oral 
      PCM in women is rare; some cases showed systemic changes at the time of PCM 
      diagnosis, namely HIV infection, pregnancy and depression. New studies should be 
      conducted to elucidate the influence of systemic alterations on the development 
      of oral PCM in women.
CI  - (c) 2020 Wiley-VCH GmbH.
FAU - Costa, Matheus de Castro
AU  - Costa MC
AD  - Department of Clinic and Surgery, School of Dentistry, Federal University of 
      Alfenas, Alfenas, MG, Brazil.
FAU - de Carvalho, Milena Moraes
AU  - de Carvalho MM
AD  - Department of Clinic and Surgery, School of Dentistry, Federal University of 
      Alfenas, Alfenas, MG, Brazil.
FAU - Sperandio, Felipe Fornias
AU  - Sperandio FF
AD  - Department of Pathology and Parasitology, Institute of Biomedical Sciences, 
      Federal University of Alfenas, Alfenas, MG, Brazil.
AD  - Oral Medicine Oral Pathology Resident, Faculty of Dentistry, University of 
      British Columbia, Vancouver, BC, Canada.
FAU - Ribeiro Junior, Noe Vital
AU  - Ribeiro Junior NV
AD  - Department of Clinic and Surgery, School of Dentistry, Federal University of 
      Alfenas, Alfenas, MG, Brazil.
FAU - Hanemann, Joao Adolfo Costa
AU  - Hanemann JAC
AD  - Department of Clinic and Surgery, School of Dentistry, Federal University of 
      Alfenas, Alfenas, MG, Brazil.
FAU - Pigossi, Suzane Cristina
AU  - Pigossi SC
AD  - Department of Clinic and Surgery, School of Dentistry, Federal University of 
      Alfenas, Alfenas, MG, Brazil.
FAU - de Carli, Marina Lara
AU  - de Carli ML
AUID- ORCID: 0000-0002-1133-6242
AD  - Department of Clinic and Surgery, School of Dentistry, Federal University of 
      Alfenas, Alfenas, MG, Brazil.
LA  - eng
GR  - MCTIC Universal no 408884/2018-5/Conselho Nacional de Desenvolvimento Cientifico 
      e Tecnologico/
GR  - Finance Code 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/
PT  - Journal Article
PT  - Systematic Review
DEP - 20201025
PL  - Germany
TA  - Mycoses
JT  - Mycoses
JID - 8805008
RN  - 304NUG5GF4 (Itraconazole)
RN  - 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination)
SB  - IM
MH  - Adult
MH  - Brazil/epidemiology
MH  - Coinfection
MH  - Databases, Factual
MH  - Female
MH  - HIV Infections
MH  - Humans
MH  - Itraconazole
MH  - Middle Aged
MH  - *Paracoccidioides
MH  - Paracoccidioidomycosis/diagnosis/*epidemiology/*microbiology
MH  - Pregnancy
MH  - Trimethoprim, Sulfamethoxazole Drug Combination
OTO - NOTNLM
OT  - HIV INFECTIONS
OT  - Paracoccidioidomycosis
OT  - depression
OT  - inflammation
OT  - mouth mucosa
OT  - pregnancy
OT  - stomatitis
OT  - women
EDAT- 2020/10/09 06:00
MHDA- 2021/07/27 06:00
CRDT- 2020/10/08 17:15
PHST- 2020/06/11 00:00 [received]
PHST- 2020/09/25 00:00 [revised]
PHST- 2020/10/01 00:00 [accepted]
PHST- 2020/10/09 06:00 [pubmed]
PHST- 2021/07/27 06:00 [medline]
PHST- 2020/10/08 17:15 [entrez]
AID - 10.1111/myc.13194 [doi]
PST - ppublish
SO  - Mycoses. 2021 Feb;64(2):108-122. doi: 10.1111/myc.13194. Epub 2020 Oct 25.