PMID- 33031843
OWN - NLM
STAT- MEDLINE
DCOM- 20210111
LR  - 20221207
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 170
DP  - 2020 Dec
TI  - Association of parameters of nocturnal hypoxemia with diabetic microvascular 
      complications: A cross-sectional study.
PG  - 108484
LID - S0168-8227(20)30737-3 [pii]
LID - 10.1016/j.diabres.2020.108484 [doi]
AB  - AIMS: To examine the association between obstructive sleep apnea (OSA)-related 
      nocturnal hypoxemia parameters and diabetic microvascular complications in 
      patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 463 Chinese 
      patients with T2DM underwent overnight polysomnography, followed by diagnosis of 
      diabetic microvascular complications including diabetic peripheral neuropathy 
      (DPN), diabetic retinopathy (DR) and diabetic nephropathy (DN). Parameters of 
      nocturnal hypoxemia, including apnea-hypopnea index (AHI), oxygen desaturation 
      index (ODI), time spent with SpO(2) < 90% (T90%) or <85% (T85%), mean SpO(2) and 
      lowest SpO(2), were recorded. RESULTS: AHI was independently associated with 
      higher odds of DPN (OR 1.19; 95% CI, 1.05-1.36; P = 0.008) after adjustment for 
      possible confounders. Moreover, patients with severe OSA (AHI >/= 30 events/h) had 
      higher likelihood of having DPN than those with mild OSA (OR 2.36; 95% CI, 
      1.31-4.25; P = 0.004). When combining DPN, DR and DN into an overall diabetic 
      microvascular complication index, AHI was also independently associated with 
      higher odds of having any diabetic microvascular complication (OR 1.21; 95% CI, 
      1.06-1.38; P = 0.006). CONCLUSIONS: The AHI may be the OSA-related index that 
      most strongly reflects the association of OSA and diabetic microvascular 
      complications, compared with other OSA-related hypoxemia parameters.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Xue, Pei
AU  - Xue P
AD  - Sleep Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 
      China.
FAU - Covassin, Naima
AU  - Covassin N
AD  - Department of Cardiovascular Medicine, Mayo Clinic College of Medicine, 
      Rochester, USA. Electronic address: Covassin.Naima@mayo.edu.
FAU - Ran, Xingwu
AU  - Ran X
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu, Sichuan, China.
FAU - Zhou, Junying
AU  - Zhou J
AD  - Sleep Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 
      China.
FAU - Zhang, Xiaohan
AU  - Zhang X
AD  - Johns Hopkins University School of Medicine, Baltimore, USA.
FAU - Yan, Donge
AU  - Yan D
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Li, Xiao
AU  - Li X
AD  - Sleep Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 
      China.
FAU - Gao, Yun
AU  - Gao Y
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu, Sichuan, China. Electronic address: gaoyun@wchscu.cn.
FAU - Tang, Xiangdong
AU  - Tang X
AD  - Sleep Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 
      China. Electronic address: 2372564613@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20201006
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - China
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Nephropathies/complications/diagnosis
MH  - Diabetic Neuropathies/complications/diagnosis
MH  - Diabetic Retinopathy/complications/diagnosis
MH  - Female
MH  - Humans
MH  - Hypoxia/*complications
MH  - Male
MH  - Middle Aged
MH  - Oxygen/metabolism
MH  - Polysomnography/methods
MH  - Sleep Apnea, Obstructive/*complications
OTO - NOTNLM
OT  - Diabetic microvascular complications
OT  - Nocturnal hypoxemia
OT  - Obstructive sleep apnea
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/10/09 06:00
MHDA- 2021/01/12 06:00
CRDT- 2020/10/08 20:10
PHST- 2020/01/02 00:00 [received]
PHST- 2020/07/28 00:00 [revised]
PHST- 2020/09/25 00:00 [accepted]
PHST- 2020/10/09 06:00 [pubmed]
PHST- 2021/01/12 06:00 [medline]
PHST- 2020/10/08 20:10 [entrez]
AID - S0168-8227(20)30737-3 [pii]
AID - 10.1016/j.diabres.2020.108484 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2020 Dec;170:108484. doi: 10.1016/j.diabres.2020.108484. 
      Epub 2020 Oct 6.