PMID- 33031918
OWN - NLM
STAT- MEDLINE
DCOM- 20210104
LR  - 20221221
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Print)
IS  - 0889-1591 (Linking)
VI  - 91
DP  - 2021 Jan
TI  - Understanding the genetic contribution of the human leukocyte antigen system to 
      common major psychiatric disorders in a world pandemic context.
PG  - 731-739
LID - S0889-1591(20)31108-9 [pii]
LID - 10.1016/j.bbi.2020.09.033 [doi]
AB  - The human leukocyte antigen (HLA) is a complex genetic system that encodes 
      proteins which predominantly regulate immune/inflammatory processes. It can be 
      involved in a variety of immuno-inflammatory disorders ranging from infections to 
      autoimmunity and cancers. The HLA system is also suggested to be involved in 
      neurodevelopment and neuroplasticity, especially through microglia regulation and 
      synaptic pruning. Consequently, this highly polymorphic gene region has recently 
      emerged as a major player in the etiology of several major psychiatric disorders, 
      such as schizophrenia, autism spectrum disorder and bipolar disorder and with 
      less evidence for major depressive disorders and attention deficit hyperactivity 
      disorder. We thus review here the role of HLA genes in particular subgroups of 
      psychiatric disorders and foresee their potential implication in future research. 
      In particular, given the prominent role that the HLA system plays in the 
      regulation of viral infection, this review is particularly timely in the context 
      of the Covid-19 pandemic.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Tamouza, Ryad
AU  - Tamouza R
AD  - Universite Paris Est Creteil, INSERM U955, IMRB, Laboratoire Neuro-Psychiatrie 
      Translationnelle, F-94010 Creteil, France; AP-HP, Hopital Henri Mondor, 
      Departement Medico-Universitaire de Psychiatrie et d'Addictologie (DMU ADAPT), 
      F-94010, France; Fondation FondaMental, Creteil, France. Electronic address: 
      tamouza.ryad@gmail.com.
FAU - Krishnamoorthy, Rajagopal
AU  - Krishnamoorthy R
AD  - Fondation FondaMental, Creteil, France.
FAU - Leboyer, Marion
AU  - Leboyer M
AD  - Universite Paris Est Creteil, INSERM U955, IMRB, Laboratoire Neuro-Psychiatrie 
      Translationnelle, F-94010 Creteil, France; AP-HP, Hopital Henri Mondor, 
      Departement Medico-Universitaire de Psychiatrie et d'Addictologie (DMU ADAPT), 
      F-94010, France; Fondation FondaMental, Creteil, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201005
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Autism Spectrum Disorder/genetics
MH  - Bipolar Disorder/genetics
MH  - COVID-19/psychology
MH  - Genetic Predisposition to Disease/genetics
MH  - HLA Antigens/*genetics/metabolism
MH  - Haplotypes/genetics
MH  - Humans
MH  - Mental Disorders/epidemiology/*genetics
MH  - Pandemics
MH  - Polymorphism, Genetic/genetics
MH  - SARS-CoV-2/pathogenicity
MH  - Schizophrenia/genetics
MH  - Virus Diseases/genetics/immunology/*psychology
PMC - PMC7534661
OTO - NOTNLM
OT  - Ancestral Haplotypes (AH)
OT  - Human Leukocyte Antigen (HLA)
OT  - Immunogenetics
OT  - Major psychiatric disorders
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2020/10/09 06:00
MHDA- 2021/01/05 06:00
PMCR- 2020/10/05
CRDT- 2020/10/08 20:10
PHST- 2020/05/26 00:00 [received]
PHST- 2020/09/01 00:00 [revised]
PHST- 2020/09/30 00:00 [accepted]
PHST- 2020/10/09 06:00 [pubmed]
PHST- 2021/01/05 06:00 [medline]
PHST- 2020/10/08 20:10 [entrez]
PHST- 2020/10/05 00:00 [pmc-release]
AID - S0889-1591(20)31108-9 [pii]
AID - 10.1016/j.bbi.2020.09.033 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2021 Jan;91:731-739. doi: 10.1016/j.bbi.2020.09.033. Epub 2020 
      Oct 5.