PMID- 33032067
OWN - NLM
STAT- MEDLINE
DCOM- 20210625
LR  - 20231104
IS  - 2213-1582 (Electronic)
IS  - 2213-1582 (Linking)
VI  - 28
DP  - 2020
TI  - Reorganization of the structural connectome in primary open angle Glaucoma.
PG  - 102419
LID - S2213-1582(20)30256-4 [pii]
LID - 10.1016/j.nicl.2020.102419 [doi]
LID - 102419
AB  - Primary open angle Glaucoma (POAG) is one of the most common causes of permanent 
      blindness in the world. Recent studies have suggested the hypothesis that POAG is 
      also a central nervous system disorder which may result in additional (i.e., 
      extra-ocular) involvement. The aim of this study is to assess possible 
      structural, whole-brain connectivity alterations in POAG patients. We evaluated 
      23 POAG patients and 15 healthy controls by combining multi-shell diffusion 
      weighted imaging, multi-shell, multi-tissue probabilistic tractography, graph 
      theoretical measures and a recently designed 'disruption index', which evaluates 
      the global reorganization of brain networks. We also studied the associations 
      between the whole-brain structural connectivity measures and indices of visual 
      acuity including the field index (VFI) and two Optical Coherence Tomography (OCT) 
      parameters, namely the Macula Ganglion Cell Layer (MaculaGCL) and Retinal Nerve 
      Fiber Layer (RNFL) thicknesses. We found both global and local structural 
      connectivity differences between POAG patients and controls, which extended well 
      beyond the primary visual pathway and were localized in the left calcarine gyrus 
      (clustering coefficient p = 0.036), left lateral occipital cortex (clustering 
      coefficient p = 0.017, local efficiency p = 0.035), right lingual gyrus 
      (clustering coefficient p = 0.009), and right paracentral lobule (clustering 
      coefficient p = 0.009, local efficiency p = 0.018). Group-wise (clustering 
      coefficient, p = 6.59∙10(-7) and local efficiency p = 6.23.10(-8)) and 
      subject-wise disruption indices (clustering coefficient, p = 0.018 and local 
      efficiency, p = 0.01) also differed between POAG patients and controls. In 
      addition, we found negative associations between RNFL thickness and local 
      measures (clustering coefficient, local efficiency and strength) in the right 
      amygdala (local efficiency p = 0.008, local strength p = 0.016), right inferior 
      temporal gyrus (clustering coefficient p = 0.036, local efficiency p = 0.042), 
      and right temporal pole (local strength p = 0.008). Overall, we show, in patients 
      with POAG, a whole-brain structural reorganization that spans across a variety of 
      brain regions involved in visual processing, motor control, and 
      emotional/cognitive functions. We also identified a pattern of brain structural 
      changes in relation to POAG clinical severity. Taken together, our findings 
      support the hypothesis that the reduction in visual acuity from POAG can be 
      driven by a combination of local (i.e., in the eye) and more extended (i.e., 
      brain) effects.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Di Cio, Francesco
AU  - Di Cio F
AD  - Medical Physics Section, Department of Biomedicine and Prevention, University of 
      Rome "Tor Vergata", Italy. Electronic address: francesco2010@hotmail.it.
FAU - Garaci, Francesco
AU  - Garaci F
AD  - Neuroradiology Unit, Department of Biomedicine and Prevention, University of Rome 
      "Tor Vergata", Rome, Italy; San Raffaele Cassino, Frosinone, Italy.
FAU - Minosse, Silvia
AU  - Minosse S
AD  - Medical Physics Section, Department of Biomedicine and Prevention, University of 
      Rome "Tor Vergata", Italy.
FAU - Passamonti, Luca
AU  - Passamonti L
AD  - Institute of Bioimaging and Molecular Physiology, National Research Council, 
      Milano, Italy; Department of Clinical Neurosciences, University of Cambridge, 
      Cambridge, UK. Electronic address: lp337@medschl.cam.ac.uk.
FAU - Martucci, Alessio
AU  - Martucci A
AD  - Ophthalmology Unit, Department of Experimental Medicine, University of Rome Tor 
      Vergata, Rome, Italy.
FAU - Lanzafame, Simona
AU  - Lanzafame S
AD  - Medical Physics Section, Department of Biomedicine and Prevention, University of 
      Rome "Tor Vergata", Italy.
FAU - Di Giuliano, Francesca
AU  - Di Giuliano F
AD  - Neuroradiology Unit, Department of Biomedicine and Prevention, University of Rome 
      "Tor Vergata", Rome, Italy.
FAU - Picchi, Eliseo
AU  - Picchi E
AD  - Diagnostic Imaging Unit, Department of Biomedicine and Prevention, University of 
      Rome "Tor Vergata", Rome, Italy.
FAU - Cesareo, Massimo
AU  - Cesareo M
AD  - Ophthalmology Unit, Department of Experimental Medicine, University of Rome Tor 
      Vergata, Rome, Italy.
FAU - Guerrisi, Maria Giovanna
AU  - Guerrisi MG
AD  - Medical Physics Section, Department of Biomedicine and Prevention, University of 
      Rome "Tor Vergata", Italy.
FAU - Floris, Roberto
AU  - Floris R
AD  - Diagnostic Imaging Unit, Department of Biomedicine and Prevention, University of 
      Rome "Tor Vergata", Rome, Italy.
FAU - Nucci, Carlo
AU  - Nucci C
AD  - Ophthalmology Unit, Department of Experimental Medicine, University of Rome Tor 
      Vergata, Rome, Italy.
FAU - Toschi, Nicola
AU  - Toschi N
AD  - Medical Physics Section, Department of Biomedicine and Prevention, University of 
      Rome "Tor Vergata", Italy; Athinoula A. Martinos Center for Biomedical Imaging 
      and Harvard Medical School, Boston, MA, USA. Electronic address: 
      toschi@med.uniroma2.it.
LA  - eng
GR  - MR/P01271X/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200909
PL  - Netherlands
TA  - Neuroimage Clin
JT  - NeuroImage. Clinical
JID - 101597070
SB  - IM
MH  - Brain/diagnostic imaging
MH  - *Connectome
MH  - *Glaucoma, Open-Angle/diagnostic imaging
MH  - Gray Matter
MH  - Humans
MH  - Tomography, Optical Coherence
PMC - PMC7552094
OTO - NOTNLM
OT  - Diffusion MRI
OT  - Graph theory
OT  - Neurodegenerative disease
OT  - Primary open angle glaucoma
OT  - Structural connectivity
OT  - Tractography
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2020/10/09 06:00
MHDA- 2021/06/29 06:00
PMCR- 2020/09/09
CRDT- 2020/10/08 20:14
PHST- 2020/05/08 00:00 [received]
PHST- 2020/09/04 00:00 [revised]
PHST- 2020/09/06 00:00 [accepted]
PHST- 2020/10/09 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2020/10/08 20:14 [entrez]
PHST- 2020/09/09 00:00 [pmc-release]
AID - S2213-1582(20)30256-4 [pii]
AID - 102419 [pii]
AID - 10.1016/j.nicl.2020.102419 [doi]
PST - ppublish
SO  - Neuroimage Clin. 2020;28:102419. doi: 10.1016/j.nicl.2020.102419. Epub 2020 Sep 
      9.