PMID- 33033463
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201010
IS  - 1477-3163 (Print)
IS  - 1477-3163 (Electronic)
IS  - 1477-3163 (Linking)
VI  - 19
DP  - 2020
TI  - Expression of Ki-67 in early glottic carcinoma and its relation to oncological 
      outcomes following CO(2) laser microsurgery.
PG  - 7
LID - 10.4103/jcar.JCar_7_20 [doi]
LID - 7
AB  - INTRODUCTION: The behavior of the laryngeal squamous cell carcinoma (LSCC) is 
      marked by the degree of cell proliferation and differentiation. Ki-67 is regarded 
      as a promising proliferation marker and has been correlated as a prognostic 
      indicator. AIM: The aim of the present study is to determine the Ki-67 expression 
      and its prognostic value in LSCC. MATERIALS AND METHODS: A total of eighty 
      patients with early glottic carcinoma stage (Tis, T(1), T(2)) N(0) M(0) were 
      included. After preoperative workup, surgery was performed using LUMINES 40C 
      CO(2) laser and tumor resection was done which was sent for histopathological 
      diagnosis and immunohistochemistry (IHC). IHC for Ki-67 expression could be done 
      only on 65 specimens. RESULTS: All patients had microscopically confirmed 
      squamous cell carcinoma. Forty-eight out of 65 specimens (75%) stained positive 
      for Ki-67 and 17 (25%) stained negative. Out of total 48, 29 stained 2+, 11 
      stained 3+ and 8 stained 4+. No difference was found in Ki-67 expression in 
      relation to age, sex, T stage, and histological grading. The association of Ki-67 
      with recurrence was found to be statistically significant. The association of 
      Ki-67 with survival was also studied and Ki-67 positivity is associated with 
      increased mortality rate, although it was not statistically significant. 
      CONCLUSION: The proliferative index as measured by immunohistochemical staining 
      of Ki-67 correlates with the tumor aggressiveness. High Ki-67 index is associated 
      with early relapse and poor survival outcomes.
CI  - Copyright: (c) 2020 Journal of Carcinogenesis.
FAU - Mittal, Shweta
AU  - Mittal S
AD  - Department of Otorhinolaryngology, Nirmal Hospital, Rishikesh, Uttarakhand, 
      India.
FAU - Bansal, Saurabh
AU  - Bansal S
AD  - Department of Radiation Oncology, Cancer Research Institute, SRHU, Dehradun, 
      Uttarakhand, India.
LA  - eng
PT  - Journal Article
DEP - 20200806
PL  - India
TA  - J Carcinog
JT  - Journal of carcinogenesis
JID - 101153623
PMC - PMC7511892
OTO - NOTNLM
OT  - Immunohistochemistry
OT  - Ki-67
OT  - proliferation
OT  - squamous cell carcinoma
COIS- There are no conflicts of interest.
EDAT- 2020/10/10 06:00
MHDA- 2020/10/10 06:01
PMCR- 2020/08/06
CRDT- 2020/10/09 05:38
PHST- 2020/03/30 00:00 [received]
PHST- 2020/04/17 00:00 [revised]
PHST- 2020/05/17 00:00 [accepted]
PHST- 2020/10/09 05:38 [entrez]
PHST- 2020/10/10 06:00 [pubmed]
PHST- 2020/10/10 06:01 [medline]
PHST- 2020/08/06 00:00 [pmc-release]
AID - JC-19-7 [pii]
AID - 10.4103/jcar.JCar_7_20 [doi]
PST - epublish
SO  - J Carcinog. 2020 Aug 6;19:7. doi: 10.4103/jcar.JCar_7_20. eCollection 2020.