PMID- 33034106
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210125
IS  - 1386-6346 (Print)
IS  - 1386-6346 (Linking)
VI  - 51
IP  - 1
DP  - 2021 Jan
TI  - Donor-dominant one-way matching of human leukocyte antigen-A/B/DR alleles 
      predicts graft-versus-host disease following living donor liver transplantation.
PG  - 135-148
LID - 10.1111/hepr.13579 [doi]
AB  - AIM: Graft-versus-host disease (GVHD) following liver transplantation is rare but 
      fatal. Therefore, it is important to identify possible risk factors before 
      transplantation. Although it has been suggested that donor-dominant one-way human 
      leukocyte antigen (HLA) matching of three loci (HLA-A/B/DR) is associated with 
      the occurrence of GVHD, the precise significance of HLA matching including 
      HLA-C/DQ/DP remains unclear. METHODS: We retrospectively analyzed the impact of 
      donor-dominant one-way HLA matching at six HLA loci at the allele level on GVHD 
      using clinical registry data from 1759 cases who underwent living donor liver 
      transplantation between June 1990 and June 2019. We extracted cases with 
      donor-dominant one-way HLA matching at the antigen level and reconfirmed them at 
      the allele level using preserved DNA samples. RESULTS: Three of four cases (75%) 
      who developed GVHD showed donor-dominant one-way HLA matching at three HLA-A/B/DR 
      loci. These cases also showed donor-dominant one-way HLA matching at HLA-C/DQ/DP. 
      Three of six cases (50%) with donor-dominant one-way HLA matching at three loci 
      of HLA-A/B/DR developed GVHD. Notably, none of the cases with donor-dominant 
      one-way HLA matching at one or two HLA-A/B/DR loci developed GVHD, irrespective 
      of matching status at HLA-C/DQ/DP. The HLA matching status at the antigen level 
      was revised in 22 of 56 cases, following reconfirmation at the allele level. 
      CONCLUSIONS: Pairing of donors and recipients with donor-dominant one-way HLA 
      matching at three HLA-A/B/DR loci should be avoided to prevent GVHD. No impact of 
      HLA-C/DQ/DP on GVHD was identified. For liver transplantation, HLA genotypes 
      should be determined at the allele level.
CI  - (c) 2020 The Japan Society of Hepatology.
FAU - Hirata, Masaaki
AU  - Hirata M
AD  - Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of 
      Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
FAU - Yagi, Shintaro
AU  - Yagi S
AUID- ORCID: 0000-0001-7465-5761
AD  - Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of 
      Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
FAU - Shindo, Takero
AU  - Shindo T
AUID- ORCID: 0000-0002-2085-6151
AD  - Department of Hematology and Oncology, Graduate School of Medicine, Kyoto 
      University, Kyoto, Japan.
FAU - Yoshizawa, Atsushi
AU  - Yoshizawa A
AD  - Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of 
      Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
FAU - Kiguchi, Gozo
AU  - Kiguchi G
AD  - Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of 
      Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
FAU - Kaneshiro, Masakatsu
AU  - Kaneshiro M
AD  - Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of 
      Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
FAU - Yurugi, Kimiko
AU  - Yurugi K
AD  - Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, 
      Kyoto, Japan.
FAU - Miyachi, Yosuke
AU  - Miyachi Y
AD  - Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of 
      Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
FAU - Iwamura, Sena
AU  - Iwamura S
AUID- ORCID: 0000-0002-3652-5904
AD  - Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of 
      Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
FAU - Yao, Siyuan
AU  - Yao S
AD  - Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of 
      Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
FAU - Uemoto, Shinji
AU  - Uemoto S
AD  - Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of 
      Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
LA  - eng
PT  - Journal Article
DEP - 20201020
PL  - Netherlands
TA  - Hepatol Res
JT  - Hepatology research : the official journal of the Japan Society of Hepatology
JID - 9711801
OTO - NOTNLM
OT  - GVHD
OT  - HLA genotyping
OT  - HLA-homozygous donor
OT  - donor selection
OT  - liver transplantation
EDAT- 2020/10/10 06:00
MHDA- 2020/10/10 06:01
CRDT- 2020/10/09 05:42
PHST- 2020/06/17 00:00 [received]
PHST- 2020/08/31 00:00 [revised]
PHST- 2020/09/18 00:00 [accepted]
PHST- 2020/10/10 06:00 [pubmed]
PHST- 2020/10/10 06:01 [medline]
PHST- 2020/10/09 05:42 [entrez]
AID - 10.1111/hepr.13579 [doi]
PST - ppublish
SO  - Hepatol Res. 2021 Jan;51(1):135-148. doi: 10.1111/hepr.13579. Epub 2020 Oct 20.