PMID- 33036701
OWN - NLM
STAT- MEDLINE
DCOM- 20201124
LR  - 20210110
IS  - 1873-4111 (Electronic)
IS  - 0378-5122 (Linking)
VI  - 141
DP  - 2020 Nov
TI  - Effect of long-term omega-3 supplementation and a lifestyle multidomain 
      intervention on intrinsic capacity among community-dwelling older adults: 
      Secondary analysis of a randomized, placebo-controlled trial (MAPT study).
PG  - 39-45
LID - S0378-5122(20)30301-7 [pii]
LID - 10.1016/j.maturitas.2020.06.012 [doi]
AB  - OBJECTIVES: To investigate the effect of omega-3 (omega-3) polyunsaturated fatty acid 
      supplementation and a multidomain intervention (MI) (physical activity 
      counselling, cognitive training and nutritional advice) among community-dwelling 
      older adults on levels of intrinsic capacity (IC), a construct recently proposed 
      by the World Health Organization. STUDY DESIGN: Secondary analysis from the 
      factorial-design 3-year Multidomain Alzheimer Preventive Trial (MAPT) with 1445 
      subjects (64.2 % female, mean age 75.3 years, SD = 4.4) randomized to one group 
      of MI plus omega-3 (800 mg docosahexaenoic acid and 225 mg eicosapentaenoic 
      acid/day); MI plus placebo; omega-3 supplementation alone; or placebo alone. Data 
      collection was held between 2008 and 2014. MAIN OUTCOME MEASURES: IC domains were 
      examined with the Geriatric Depression Scale (psychological); Short Physical 
      Performance Battery (mobility); Z-score combining four tests (cognitive 
      function); and handgrip strength (vitality). All domains were combined into a 
      composite IC Z-score. RESULTS: After 3 years, IC Z-score decreased among all 
      groups when time was considered continuous (MI plus omega-3: -0.16, 95 %CI: -0.22 to 
      -0.10; MI alone: -0.13, 95 %CI: -0.19 to -0.07; omega-3 alone: -0.19, 95 %CI: -0.25 
      to -0.10; placebo: -0.20, 95 %CI: -0.26 to -0.14; all p < 0.0001). There were no 
      significant differences between groups. In a sensitivity analysis with 
      categorical time, significant within-group declines were first identified at 24 
      months for all groups. CONCLUSIONS: This trial designed to improve cognitive 
      function was unable to find effects of the intervention on the composite IC 
      Z-score. Further investigations are needed, especially trials providing stronger 
      interventions (such as exercise training and a controlled diet) and also 
      embracing the sensorial domain of IC.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Giudici, K V
AU  - Giudici KV
AD  - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU 
      Toulouse), Toulouse, France. Electronic address: kellygiudici@gmail.com.
FAU - de Souto Barreto, P
AU  - de Souto Barreto P
AD  - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU 
      Toulouse), Toulouse, France; UPS/Inserm UMR1027, University of Toulouse III, 
      Toulouse, France.
FAU - Beard, J
AU  - Beard J
AD  - University of Sydney, Sydney, Australia.
FAU - Cantet, C
AU  - Cantet C
AD  - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU 
      Toulouse), Toulouse, France; UPS/Inserm UMR1027, University of Toulouse III, 
      Toulouse, France.
FAU - Araujo de Carvalho, I
AU  - Araujo de Carvalho I
AD  - Department of Ageing and Life Course, World Health Organization, Geneva, 
      Switzerland.
FAU - Rolland, Y
AU  - Rolland Y
AD  - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU 
      Toulouse), Toulouse, France; UPS/Inserm UMR1027, University of Toulouse III, 
      Toulouse, France.
FAU - Vellas, B
AU  - Vellas B
AD  - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU 
      Toulouse), Toulouse, France; UPS/Inserm UMR1027, University of Toulouse III, 
      Toulouse, France.
CN  - MAPT DSA group
LA  - eng
GR  - 001/WHO_/World Health Organization/International
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20200626
PL  - Ireland
TA  - Maturitas
JT  - Maturitas
JID - 7807333
RN  - 0 (Fatty Acids, Omega-3)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - 6GC8A4PAYH (eicosapentaenoic acid ethyl ester)
RN  - AAN7QOV9EA (Eicosapentaenoic Acid)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*prevention & control
MH  - Cognition/*drug effects
MH  - Dietary Supplements
MH  - Docosahexaenoic Acids
MH  - Eicosapentaenoic Acid/analogs & derivatives
MH  - Exercise
MH  - Fatty Acids, Omega-3/pharmacology/*therapeutic use
MH  - Female
MH  - Geriatric Assessment
MH  - Hand Strength
MH  - Healthy Lifestyle
MH  - Humans
MH  - Independent Living
MH  - Life Style
MH  - Longitudinal Studies
MH  - Male
MH  - Range of Motion, Articular/drug effects
OTO - NOTNLM
OT  - Aging
OT  - Alzheimer's
OT  - Clinical trials
OT  - Cognition
OT  - Functional performance
OT  - Intrinsic capacity
EDAT- 2020/10/11 06:00
MHDA- 2020/11/25 06:00
CRDT- 2020/10/10 05:24
PHST- 2020/01/22 00:00 [received]
PHST- 2020/05/19 00:00 [revised]
PHST- 2020/06/16 00:00 [accepted]
PHST- 2020/10/10 05:24 [entrez]
PHST- 2020/10/11 06:00 [pubmed]
PHST- 2020/11/25 06:00 [medline]
AID - S0378-5122(20)30301-7 [pii]
AID - 10.1016/j.maturitas.2020.06.012 [doi]
PST - ppublish
SO  - Maturitas. 2020 Nov;141:39-45. doi: 10.1016/j.maturitas.2020.06.012. Epub 2020 
      Jun 26.