PMID- 33036866
OWN - NLM
STAT- MEDLINE
DCOM- 20210917
LR  - 20210917
IS  - 1769-7131 (Electronic)
IS  - 0987-7053 (Linking)
VI  - 50
IP  - 5
DP  - 2020 Oct
TI  - Prepulse inhibition and recovery of trigemino-cervical reflex in patients with 
      cervical dystonia.
PG  - 361-366
LID - S0987-7053(20)30101-5 [pii]
LID - 10.1016/j.neucli.2020.09.003 [doi]
AB  - OBJECTIVE: We aimed to analyze the prepulse inhibition (PPI) and recovery rate 
      (R) of the trigeminocervical reflex (TCR) in patients with cervical dystonia 
      (CD). METHODS: We enrolled 15 patients with CD and 16 healthy subjects. TCR was 
      recorded over splenius capitis after infraorbital nerve stimulation. For TCR-PPI, 
      we applied a prepulse stimulus to the left second finger 100 ms prior to the test 
      stimulus and the percentage of change of response to test stimulus was 
      calculated. For TCR-R, we applied paired infraorbital stimuli at interstimulus 
      interval (ISIs) of 300 ms and the percentage of change of the second compared to 
      the first response was calculated. RESULTS: TCR-PPI and TCR-R values were higher 
      (less inhibition and greater recovery) on both sides in the patient group 
      compared to healthy subjects. There was high correlation between TCR-PPI and 
      TCR-R on both sides in patients with dystonia (p < 0.005). We did not find any 
      significant relationship between TCR-R or TCR-PPI and side of dystonic posture. 
      CONCLUSIONS: We showed disturbed modulation of TCR in CD patients. In CD, a 
      general inhibition of the inhibitory pathways and facilitation of the excitatory 
      pathways occur. Although TCR was recorded directly on the affected muscles in CD, 
      symmetric abnormal TCR findings in CD suggest that these findings are probably 
      secondary to altered function of higher order centers rather than being directly 
      related to the pathophysiological process.
CI  - Copyright (c) 2020 Elsevier Masson SAS. All rights reserved.
FAU - Asan, Furkan
AU  - Asan F
AD  - Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Department of 
      Neurology, Turkey. Electronic address: furkan61asan@gmail.com.
FAU - Gunduz, Aysegul
AU  - Gunduz A
AD  - Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Department of 
      Neurology, Turkey.
FAU - E Kiziltan, Meral
AU  - E Kiziltan M
AD  - Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Department of 
      Neurology, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20201007
PL  - France
TA  - Neurophysiol Clin
JT  - Neurophysiologie clinique = Clinical neurophysiology
JID - 8804532
SB  - IM
MH  - Acoustic Stimulation
MH  - Electric Stimulation
MH  - Humans
MH  - Neck Muscles
MH  - Prepulse Inhibition
MH  - Reflex
MH  - Reflex, Startle
MH  - *Torticollis/therapy
OTO - NOTNLM
OT  - Cervical dystonia
OT  - Percentage
OT  - Prepulse inhibition
OT  - Recovery
OT  - Trigeminocervical reflex
EDAT- 2020/10/11 06:00
MHDA- 2021/09/18 06:00
CRDT- 2020/10/10 05:27
PHST- 2020/03/25 00:00 [received]
PHST- 2020/09/05 00:00 [revised]
PHST- 2020/09/06 00:00 [accepted]
PHST- 2020/10/11 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2020/10/10 05:27 [entrez]
AID - S0987-7053(20)30101-5 [pii]
AID - 10.1016/j.neucli.2020.09.003 [doi]
PST - ppublish
SO  - Neurophysiol Clin. 2020 Oct;50(5):361-366. doi: 10.1016/j.neucli.2020.09.003. 
      Epub 2020 Oct 7.