PMID- 33037403 OWN - NLM STAT- MEDLINE DCOM- 20210705 LR - 20210708 IS - 1476-5365 (Electronic) IS - 0268-3369 (Linking) VI - 56 IP - 3 DP - 2021 Mar TI - Individual HLAs influence immunological events in allogeneic stem cell transplantation from HLA-identical sibling donors. PG - 646-654 LID - 10.1038/s41409-020-01070-3 [doi] AB - In allogeneic hematopoietic stem cell transplantation (allo-HSCT), the effects of patient and donor human leukocyte antigen (HLA) matching status on graft-versus-host disease (GVHD) have been extensively elucidated, but the effects of specific HLAs on acute GVHD remain unclear. Using data from a Japanese registry, we retrospectively analyzed 4392 patients with leukemia or myelodysplastic syndrome who received transplants from HLA-identical sibling donors to investigate the effects of HLAs on acute GVHD. From unbiased searches of HLA-A, -B, and -DR, HLA-B60 was significantly associated with an increased risk of grades II-IV acute GVHD (HR, 1.34; 95% CI, 1.13-1.59; P = 0.001). In contrast, HLA-B62 was significantly associated with a decreased risk of grades II-IV (HR, 0.73; 95% CI, 0.62-0.87; P < 0.001) and III-IV acute GVHD (HR, 0.63; 95% CI, 0.46-0.87; P = 0.005). The risk of leukemia relapse was significantly higher in HLA-B62-positive patients than in HLA-B62-negative patients (HR, 1.23; 95% CI, 1.05-1.43; P = 0.01). Both HLA-B60 and -B62 did not affect overall survival. The findings of this study may by implication suggest the possibility that the effects of specific HLAs on transplant outcomes may reflect inherent biological features, and thus consideration of specific HLAs may be helpful to predict transplant outcomes. FAU - Morishima, Satoko AU - Morishima S AUID- ORCID: 0000-0002-7391-4271 AD - Division of Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, Second Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan. smorishi@med.u-ryukyu.ac.jp. FAU - Fukuda, Takahiro AU - Fukuda T AD - Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan. FAU - Doki, Noriko AU - Doki N AD - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan. FAU - Mori, Takehiko AU - Mori T AUID- ORCID: 0000-0002-8176-4760 AD - Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. FAU - Onizuka, Makoto AU - Onizuka M AD - Department of Hematology/Oncology, Tokai University School of Medicine, Isehara, Japan. FAU - Kawakita, Toshihiro AU - Kawakita T AD - Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan. FAU - Kato, Chiaki AU - Kato C AD - Department of Hematology, Meitetsu Hospital, Nagoya, Japan. FAU - Ozawa, Yukiyasu AU - Ozawa Y AD - Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan. FAU - Tanaka, Masatsugu AU - Tanaka M AD - Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan. FAU - Kurokawa, Mineo AU - Kurokawa M AD - Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Tokyo, Japan. FAU - Kamimura, Tomohiko AU - Kamimura T AD - Department of Hematology, Harasanshin Hospital, Fukuoka, Japan. FAU - Inoue, Masami AU - Inoue M AD - Department of Hematology/Oncology, Osaka Women's and Children's Hospital, Izumi, Japan. FAU - Tanaka, Junji AU - Tanaka J AD - Department of Hematology, Tokyo Women's Medical University, Tokyo, Japan. FAU - Ichinohe, Tatsuo AU - Ichinohe T AD - Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan. FAU - Atsuta, Yoshiko AU - Atsuta Y AUID- ORCID: 0000-0003-4404-2870 AD - Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan. AD - Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Morishima, Yasuo AU - Morishima Y AD - Central Japan Cord Blood Bank, Seto, Japan. AD - Department of Hematology and Oncology, Nakagami Hospital, Okinawa, Japan. AD - Department of Promotion for Blood and Marrow Transplantation, Aichi Medical University School of Medicine, Nagakute, Japan. CN - HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20201009 PL - England TA - Bone Marrow Transplant JT - Bone marrow transplantation JID - 8702459 RN - 0 (HLA Antigens) SB - IM MH - *Graft vs Host Disease MH - HLA Antigens MH - *Hematopoietic Stem Cell Transplantation MH - Humans MH - Retrospective Studies MH - Siblings FIR - Morishima, Satoko IR - Morishima S FIR - Atsuta, Yoshiko IR - Atsuta Y FIR - Ikegame, Kazuhiro IR - Ikegame K FIR - Ichinohe, Tatsuo IR - Ichinohe T FIR - Utsunomiya, Atae IR - Utsunomiya A FIR - Onizuka, Makoto IR - Onizuka M FIR - Kato, Shunichi IR - Kato S FIR - Kawase, Takakazu IR - Kawase T FIR - Kanda, Junya IR - Kanda J FIR - Kanda, Yoshinobu IR - Kanda Y FIR - Kim, Sung-Won IR - Kim SW FIR - Kobayashi, Takeshi IR - Kobayashi T FIR - Takatsuka, Yoshifusa IR - Takatsuka Y FIR - Takahashi, Yoshiyuki IR - Takahashi Y FIR - Tanaka, Junji IR - Tanaka J FIR - Tamaki, Hiroya IR - Tamaki H FIR - Tsuji, Masanori IR - Tsuji M FIR - Nishida, Tetsuya IR - Nishida T FIR - Maeda, Yoshinobu IR - Maeda Y FIR - Masuko, Masayoshi IR - Masuko M FIR - Matsuno, Ryosuke IR - Matsuno R FIR - Murata, Makoto IR - Murata M FIR - Morishima, Yasuo IR - Morishima Y FIR - Yokoyama, Hisayuki IR - Yokoyama H FIR - Wake, Atsushi IR - Wake A FIR - Watanabe, Nobuhiro IR - Watanabe N FIR - Ashida, Takashi IR - Ashida T FIR - Takanashi, Minoko IR - Takanashi M FIR - Hoshino, Takumi IR - Hoshino T FIR - Yabe, Toshio IR - Yabe T FIR - Sakamoto, Kana IR - Sakamoto K FIR - Fuji, Shigeo IR - Fuji S FIR - Miyamura, Koichi IR - Miyamura K FIR - Arima, Nobuyoshi IR - Arima N FIR - Kondo, Eisei IR - Kondo E FIR - Kawamura, Koji IR - Kawamura K FIR - Kawata, Takahito IR - Kawata T FIR - Kishimoto, Kenji IR - Kishimoto K FIR - Tatara, Raine IR - Tatara R FIR - Hagino, Takeshi IR - Hagino T FIR - Fujiwara, Shin-Ichiro IR - Fujiwara SI FIR - Shimomura, Yoshimitsu IR - Shimomura Y FIR - Sakaguchi, Hirotoshi IR - Sakaguchi H FIR - Hirabayashi, Shigeki IR - Hirabayashi S FIR - Ishii, Hiroto IR - Ishii H FIR - Onda, Yoshiyuki IR - Onda Y FIR - Kato, Itaru IR - Kato I FIR - Kawajiri, Akihisa IR - Kawajiri A FIR - Shindo, Takero IR - Shindo T FIR - Tokunaga, Masahito IR - Tokunaga M FIR - Nonami, Atsushi IR - Nonami A FIR - Muranushi, Hiroyuki IR - Muranushi H FIR - Yoshinaga, Noriyoshi IR - Yoshinaga N FIR - Kawashima, Naomi IR - Kawashima N FIR - Shiratori, Souichi IR - Shiratori S FIR - Tada, Yuma IR - Tada Y FIR - Tanoue, Susumu IR - Tanoue S FIR - Hirayama, Masahiro IR - Hirayama M FIR - Fukunaga, Keiko IR - Fukunaga K FIR - Ohbiki, Marie IR - Ohbiki M FIR - Azuma, Fumihiro IR - Azuma F FIR - Kaneya, Minoru IR - Kaneya M FIR - Fujino, Takahiro IR - Fujino T FIR - Yamashita, Takaya IR - Yamashita T FIR - Tomori, Shouhei IR - Tomori S FIR - Takeuchi, Yuki IR - Takeuchi Y FIR - Sato, Takahiko IR - Sato T FIR - Morita, Kaoru IR - Morita K FIR - Tanaka, Norina IR - Tanaka N FIR - Wada, Fumiya IR - Wada F FIR - Edahiro, Taro IR - Edahiro T FIR - Iwasaki, Makoto IR - Iwasaki M FIR - Umino, Kento IR - Umino K EDAT- 2020/10/11 06:00 MHDA- 2021/07/06 06:00 CRDT- 2020/10/10 05:32 PHST- 2019/10/01 00:00 [received] PHST- 2020/09/21 00:00 [accepted] PHST- 2020/09/16 00:00 [revised] PHST- 2020/10/11 06:00 [pubmed] PHST- 2021/07/06 06:00 [medline] PHST- 2020/10/10 05:32 [entrez] AID - 10.1038/s41409-020-01070-3 [pii] AID - 10.1038/s41409-020-01070-3 [doi] PST - ppublish SO - Bone Marrow Transplant. 2021 Mar;56(3):646-654. doi: 10.1038/s41409-020-01070-3. Epub 2020 Oct 9.