PMID- 33037727
OWN - NLM
STAT- MEDLINE
DCOM- 20210628
LR  - 20210628
IS  - 1432-2277 (Electronic)
IS  - 0934-0874 (Linking)
VI  - 34
IP  - 1
DP  - 2021 Jan
TI  - Liver transplantation from brain-dead donors on mechanical circulatory support: a 
      systematic review of the literature.
PG  - 5-15
LID - 10.1111/tri.13766 [doi]
AB  - Mechanical circulatory support (MCS) refers to a range of rescue devices to 
      assist circulation for the treatment of heart failure, including venoarterial 
      extracorporeal membrane oxygenation (VA-ECMO) and ventricular assist devices 
      (VADs). This review aims at evaluating the transplant outcome of the livers 
      procured from brain-dead donors on MCS, who are currently considered as having 
      extended criteria. We identified 22 records (17 on VA-ECMO and 5 on VADs), most 
      of which (68.2%) were case reports. We performed a meta-analysis only when the 
      outcome was reported homogeneously among studies; otherwise, we illustrated the 
      results with narrative synthesis. A total of 156 liver transplants (LTs) have 
      been reported, where VA-ECMO was initiated in the donor with resuscitative intent 
      or as a bridge to donation. Early graft survival approached 100% in most studies. 
      The pooled rate of primary nonfunction was 1% (95% CI: 0-3%). Only three 
      successful LTs from VAD donors have been reported. Particular attention should be 
      paid to cardiological history, biochemical tests, and imaging, as well as MCS 
      parameters, to determine graft eligibility for transplantation. Although further 
      analysis is needed in this field, the results of this review advocate a more 
      systematic consideration of brain-dead patients on MCS as potential liver donors.
CI  - (c) 2020 Steunstichting ESOT. Published by John Wiley & Sons Ltd.
FAU - De Carlis, Riccardo
AU  - De Carlis R
AUID- ORCID: 0000-0003-3697-1653
AD  - Department of General Surgery and Transplantation, ASST Grande Ospedale 
      Metropolitano Niguarda, Milan, Italy.
FAU - Buscemi, Vincenzo
AU  - Buscemi V
AD  - Department of General Surgery and Transplantation, ASST Grande Ospedale 
      Metropolitano Niguarda, Milan, Italy.
FAU - Checchini, Giuliana
AU  - Checchini G
AD  - Department of General Surgery and Transplantation, ASST Grande Ospedale 
      Metropolitano Niguarda, Milan, Italy.
AD  - Department of Surgical Sciences, University of Pavia, Pavia, Italy.
FAU - Frassoni, Samuele
AU  - Frassoni S
AD  - Department of Statistics and Quantitative Methods, University of Milano-Bicocca, 
      Milan, Italy.
FAU - Bagnardi, Vincenzo
AU  - Bagnardi V
AD  - Department of Statistics and Quantitative Methods, University of Milano-Bicocca, 
      Milan, Italy.
FAU - Pagnanelli, Michele
AU  - Pagnanelli M
AD  - Department of General Surgery and Transplantation, ASST Grande Ospedale 
      Metropolitano Niguarda, Milan, Italy.
AD  - Department of General Surgery, IRCCS San Raffaele Scientific Institute, 
      Vita-Salute University, Milan, Italy.
FAU - Lauterio, Andrea
AU  - Lauterio A
AUID- ORCID: 0000-0001-6110-8582
AD  - Department of General Surgery and Transplantation, ASST Grande Ospedale 
      Metropolitano Niguarda, Milan, Italy.
FAU - De Carlis, Luciano
AU  - De Carlis L
AD  - Department of General Surgery and Transplantation, ASST Grande Ospedale 
      Metropolitano Niguarda, Milan, Italy.
AD  - Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20201028
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ 
      Transplantation
JID - 8908516
SB  - IM
MH  - Brain
MH  - *Heart Transplantation
MH  - *Heart-Assist Devices
MH  - Humans
MH  - *Liver Transplantation
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - donation after brain death
OT  - extended criteria donors
OT  - extracorporeal membrane oxygenation
OT  - liver transplantation
OT  - organ procurement
OT  - ventricular assist devices
EDAT- 2020/10/11 06:00
MHDA- 2021/06/29 06:00
CRDT- 2020/10/10 05:36
PHST- 2020/07/25 00:00 [received]
PHST- 2020/08/18 00:00 [revised]
PHST- 2020/10/05 00:00 [accepted]
PHST- 2020/10/11 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2020/10/10 05:36 [entrez]
AID - 10.1111/tri.13766 [doi]
PST - ppublish
SO  - Transpl Int. 2021 Jan;34(1):5-15. doi: 10.1111/tri.13766. Epub 2020 Oct 28.