PMID- 33038386
OWN - NLM
STAT- MEDLINE
DCOM- 20211118
LR  - 20211118
IS  - 1879-0542 (Electronic)
IS  - 0165-2478 (Linking)
VI  - 228
DP  - 2020 Dec
TI  - IL-18 variant increases risk of enhanced HBV DNA replication in chronic 
      hepatitis.
PG  - 70-75
LID - S0165-2478(20)30398-9 [pii]
LID - 10.1016/j.imlet.2020.10.002 [doi]
AB  - BACKGROUND: The outcome ofhepatitis B (HBV) infection is influenced by immune 
      responses and host genetics. Interleukin-18 (IL-18) is a determinant factor in 
      controlling the balance of Th1/Th2 during antiviral response.Weexamine therole of 
      two functional polymorphisms -607A/C and-137A/C inIL-18 gene with risk of chronic 
      HBV infection. METHODS AND RESULTS: Genomic DNA isolates were obtained from 200 
      seropositive cases stratified according to their HBV DNA loads, and 200 blood 
      donorsas a control population. Genotypes of the two polymorphisms were identified 
      by ARMS-PCR method. The -607A allele, the-607AA and -607AC genotypes were 
      associated with increased risk to develop chronic HBV infection (1.98, 5.11 and 
      3.5-fold risks, respectively). By contrast, the -137C minor allele and CG 
      genotype had protected effects against chronic HBV infection. We found that -607A 
      allele, -607AA and -607AC genotypes were significantly more frequent in patient's 
      group with high HBV DNA levels compared to patient group with low HBV DNA level. 
      Additionally, they were associated with increased 1.72, 6.04 and 3.28-fold risk 
      of high HBV DNA replication. Patients carrying "-607A/-137 C" or "-607A/-137 G" 
      haplotypes presented a high risk to develop chronic HBV infection (OR = 3.27; OR 
      = 4.32, respectively). CONCLUSIONS: Taken together, our data suggest that 
      theIL-18 -607A/C functional polymorphism was associated with susceptibility to 
      enhanced replicative form of HBV DNA in chronic infection.
CI  - Copyright (c) 2020. Published by Elsevier B.V.
FAU - Ben Selma, Walid
AU  - Ben Selma W
AD  - Laboratory of Microbiology, UR12SP34, University Hospital Farhat Hached, Sousse, 
      Tunisia; Laboratory of Biological and Genetic Markers Studying for Early 
      Diagnosis and Follow-Up of Neurological Diseases, LR18ES47, Faculty of Medicine, 
      Sousse, Tunisia; Higher Institute of Applied Sciences and Technology, Mahdia, 
      Tunisia. Electronic address: walid.bensalma@issatmh.u-monastir.tn.
FAU - Alibi, Sana
AU  - Alibi S
AD  - Laboratory of Biological and Genetic Markers Studying for Early Diagnosis and 
      Follow-Up of Neurological Diseases, LR18ES47, Faculty of Medicine, Sousse, 
      Tunisia.
FAU - Smach, Mohamed Ali
AU  - Smach MA
AD  - Laboratory of Biological and Genetic Markers Studying for Early Diagnosis and 
      Follow-Up of Neurological Diseases, LR18ES47, Faculty of Medicine, Sousse, 
      Tunisia.
FAU - Saad, Afef
AU  - Saad A
AD  - Department of Microbiology, Faculty of Medicine, Sousse, Tunisia.
FAU - Boukadida, Jalel
AU  - Boukadida J
AD  - Laboratory of Microbiology, UR12SP34, University Hospital Farhat Hached, Sousse, 
      Tunisia; Laboratory of Biological and Genetic Markers Studying for Early 
      Diagnosis and Follow-Up of Neurological Diseases, LR18ES47, Faculty of Medicine, 
      Sousse, Tunisia; Department of Microbiology, Faculty of Medicine, Sousse, 
      Tunisia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201007
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 0 (DNA, Viral)
RN  - 0 (IL18 protein, human)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *DNA Replication
MH  - DNA, Viral/*biosynthesis/genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Hepatitis B virus/genetics/*growth & development/immunology
MH  - Hepatitis B, Chronic/diagnosis/*genetics/immunology/virology
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Protective Factors
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Tunisia
MH  - *Virus Replication
MH  - Young Adult
OTO - NOTNLM
OT  - Chronic HBV infection
OT  - DNA replication
OT  - Interleukin-18
OT  - Polymorphism
OT  - Susceptibility
EDAT- 2020/10/11 06:00
MHDA- 2021/11/19 06:00
CRDT- 2020/10/10 20:09
PHST- 2020/07/15 00:00 [received]
PHST- 2020/09/24 00:00 [revised]
PHST- 2020/10/01 00:00 [accepted]
PHST- 2020/10/11 06:00 [pubmed]
PHST- 2021/11/19 06:00 [medline]
PHST- 2020/10/10 20:09 [entrez]
AID - S0165-2478(20)30398-9 [pii]
AID - 10.1016/j.imlet.2020.10.002 [doi]
PST - ppublish
SO  - Immunol Lett. 2020 Dec;228:70-75. doi: 10.1016/j.imlet.2020.10.002. Epub 2020 Oct 
      7.