PMID- 33039533
OWN - NLM
STAT- MEDLINE
DCOM- 20210408
LR  - 20210408
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 165
IP  - Pt A
DP  - 2020 Dec 15
TI  - Electrospun tetracycline hydrochloride loaded zein/gum tragacanth/poly lactic 
      acid nanofibers for biomedical application.
PG  - 1312-1322
LID - S0141-8130(20)34586-4 [pii]
LID - 10.1016/j.ijbiomac.2020.09.225 [doi]
AB  - Newly, fabrication of scaffolds along with the therapeutic agent of tetracycline 
      hydrochloride for application in wound healing and anti-inflammatory effect could 
      interest consideration. In this work, we developed a novel drug delivery mat 
      composed of gum tragacanth (GT), zein, poly lactic acid (PLA) and tetracycline 
      hydrochloride (TCH) (zein/GT/PLA/TCH) in different blending ratios of zein/GT. 
      Scanning electron microscope (SEM) images of mats showed interconnected pores 
      with beadles nanofibers. The results of SEM showed that by increasing the ratio 
      of zein/GT, the average diameter of nanofibers increased from 253.22 +/- 15.36 to 
      547.78 +/- 56.48 nm for the ratios of 80:20 and 90:10, respectively. Moreover, the 
      successful loading of TCH and was approved by Fourier transform infrared (FTIR) 
      spectroscopy and thermal gravimetric analysis (TGA). By addition of TCH and 
      increasing the GT content to the developed nanofibrous mats, the tensile 
      strength, swelling degree and porosity of zein/GT/PLA/TCH nanofibers increased. 
      Furthermore, this scaffold also displayed appropriate antibacterial properties 
      and suitable degradability for skin tissue engineering. The results of 
      cytocompatibility and SEM micrographs proved that zein/GT/PLA/TCH scaffold had 
      promising proliferation and adhesion against NIH-3 T3 fibroblast cell.
CI  - Copyright (c) 2020. Published by Elsevier B.V.
FAU - Ghorbani, Marjan
AU  - Ghorbani M
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.. Electronic address: ghorbanim@tbzmed.ac.ir.
FAU - Mahmoodzadeh, Farideh
AU  - Mahmoodzadeh F
AD  - Halal Research Center of IRI, FDA, Tehran, Iran.
FAU - Yavari Maroufi, Leila
AU  - Yavari Maroufi L
AD  - Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Nezhad-Mokhtari, Parinaz
AU  - Nezhad-Mokhtari P
AD  - Student Research Committee, Department of Medical Nanotechnology, Faculty of 
      Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20201008
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polyesters)
RN  - 459TN2L5F5 (poly(lactide))
RN  - 9000-65-1 (Tragacanth)
RN  - 9010-66-6 (Zein)
RN  - F8VB5M810T (Tetracycline)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/chemistry/*pharmacology
MH  - Biocompatible Materials/chemistry/pharmacology
MH  - *Drug Delivery Systems
MH  - Fibroblasts/drug effects
MH  - Humans
MH  - Mice
MH  - NIH 3T3 Cells
MH  - Nanofibers/chemistry
MH  - Polyesters/chemistry
MH  - Tetracycline/*chemistry/pharmacology
MH  - Tragacanth/chemistry
MH  - Zein/*chemistry/pharmacology
OTO - NOTNLM
OT  - Nanofibrous scaffold
OT  - Tetracycline hydrochloride
OT  - Wound healing
COIS- Declaration of competing interest There are no conflicts to declare.
EDAT- 2020/10/12 06:00
MHDA- 2021/04/10 06:00
CRDT- 2020/10/11 20:24
PHST- 2020/07/26 00:00 [received]
PHST- 2020/09/12 00:00 [revised]
PHST- 2020/09/24 00:00 [accepted]
PHST- 2020/10/12 06:00 [pubmed]
PHST- 2021/04/10 06:00 [medline]
PHST- 2020/10/11 20:24 [entrez]
AID - S0141-8130(20)34586-4 [pii]
AID - 10.1016/j.ijbiomac.2020.09.225 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2020 Dec 15;165(Pt A):1312-1322. doi: 
      10.1016/j.ijbiomac.2020.09.225. Epub 2020 Oct 8.