PMID- 33040631
OWN - NLM
STAT- MEDLINE
DCOM- 20220825
LR  - 20220825
IS  - 1471-1753 (Electronic)
IS  - 0954-6634 (Linking)
VI  - 33
IP  - 3
DP  - 2022 May
TI  - Beneficial effect of Lactobacillus plantarum IS-10506 supplementation in adults 
      with atopic dermatitis: a randomized controlled trial.
PG  - 1491-1498
LID - 10.1080/09546634.2020.1836310 [doi]
AB  - INTRODUCTION: Although the therapeutic effects of probiotics in atopic dermatitis 
      (AD) are known, the limited findings in adults are inconsistent. Lactobacillus 
      plantarum (LP) IS-10506 was found to improve AD symptoms due to its 
      immunomodulatory effects. OBJECTIVE: To assess the Scoring Atopic Dermatitis 
      Index (SCORAD), the serum immunoglobulin E (IgE), interleukin (IL)-4, 
      interferon-gamma (IFN-gamma), forkhead box P3 (Foxp3+), and IL-17 levels in adults 
      with mild and moderate AD after LP IS-10506 supplementation. METHODS: A 
      randomized double-blind placebo-controlled trial comparing the microencapsulated 
      probiotic (2 x 10(10) CFU/day) and placebo (skim milk-Avicel) was conducted at an 
      outpatient clinic on 30 adults with mild and moderate AD. The patients were 
      divided into 2 groups with 15 patients each: intervention and control. RESULT: 
      The SCORAD score was significantly lower in the probiotic than the placebo group 
      on the 8th week. The IL-4 and IL-17 levels were significantly lower in the 
      probiotic than the placebo group. The IFN-gamma and Foxp3+ levels were significantly 
      higher in the probiotic than the placebo group. However, the IgE levels remained 
      significantly unchanged. CONCLUSION: The administration of LP IS-10506 is 
      effective for alleviating AD symptoms in adults owing to its immunomodulatory 
      effects.
FAU - Prakoeswa, C R S
AU  - Prakoeswa CRS
AUID- ORCID: 0000-0001-5325-2963
AD  - Faculty of Medicine, Department of Dermatology and Venereology, Dr. Soetomo 
      Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia.
FAU - Bonita, L
AU  - Bonita L
AD  - Faculty of Medicine, Department of Dermatology and Venereology, Dr. Soetomo 
      Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia.
FAU - Karim, A
AU  - Karim A
AD  - Faculty of Medicine, Department of Dermatology and Venereology, Dr. Soetomo 
      Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia.
FAU - Herwanto, N
AU  - Herwanto N
AD  - Faculty of Medicine, Department of Dermatology and Venereology, Dr. Soetomo 
      Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia.
FAU - Umborowati, M A
AU  - Umborowati MA
AUID- ORCID: 0000-0003-0940-8689
AD  - Faculty of Medicine, Department of Dermatology and Venereology, Dr. Soetomo 
      Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia.
FAU - Setyaningrum, T
AU  - Setyaningrum T
AD  - Faculty of Medicine, Department of Dermatology and Venereology, Dr. Soetomo 
      Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia.
FAU - Hidayati, A N
AU  - Hidayati AN
AD  - Faculty of Medicine, Department of Dermatology and Venereology, Dr. Soetomo 
      Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia.
FAU - Surono, I S
AU  - Surono IS
AUID- ORCID: 0000-0002-2222-609X
AD  - Faculty of Engineering, Food Technology Department, Bina Nusantara University, 
      Jakarta, Indonesia.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20201108
PL  - England
TA  - J Dermatolog Treat
JT  - The Journal of dermatological treatment
JID - 8918133
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Interleukin-17)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - *Dermatitis, Atopic/drug therapy
MH  - Double-Blind Method
MH  - Forkhead Transcription Factors/therapeutic use
MH  - Humans
MH  - Immunoglobulin E
MH  - Interleukin-17
MH  - *Lactobacillus plantarum
MH  - *Probiotics/therapeutic use
MH  - Severity of Illness Index
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - Lactobacillus plantarum
OT  - adult
OT  - probiotic
EDAT- 2020/10/13 06:00
MHDA- 2022/08/26 06:00
CRDT- 2020/10/12 05:19
PHST- 2020/10/13 06:00 [pubmed]
PHST- 2022/08/26 06:00 [medline]
PHST- 2020/10/12 05:19 [entrez]
AID - 10.1080/09546634.2020.1836310 [doi]
PST - ppublish
SO  - J Dermatolog Treat. 2022 May;33(3):1491-1498. doi: 10.1080/09546634.2020.1836310. 
      Epub 2020 Nov 8.