PMID- 33040814
OWN - NLM
STAT- MEDLINE
DCOM- 20210603
LR  - 20210603
IS  - 1165-158X (Electronic)
IS  - 0145-5680 (Linking)
VI  - 66
IP  - 5
DP  - 2020 Jul 31
TI  - Effects of oral desloratadine citrate disodium combined with physiological 
      seawater nasal irrigation on IgE levels, IL-4, IL-6, IL-13 and IFN-gamma expression 
      and treatment of intermittent allergic rhinitis.
PG  - 54-58
AB  - This experiment was performed to explore the effect of oral desloratadine citrate 
      disodium combined with physiological seawater nasal irrigation in the treatment 
      of intermittent allergic rhinitis and its effect on serum inflammatory factors 
      and peripheral blood Th1 and Th2. For this purpose, 100 patients of intermittent 
      allergic rhinitis admitted to our hospital from January 2018 to January 2020. 
      Randomly divided into a control group (n=50) and an observation group (n=50). The 
      control group was given oral desloratadine citrate disodium. The observation 
      group was given physiological seawater nasal irrigation based on the control 
      group. Both groups were treated for one month. Compare the effect of treatment, 
      symptom and sign scores pre and posttreatment, serum immunoglobulin E (IgE) 
      levels, serum interleukin 4 (IL-4), IL-6, IL-13 and interferon-gamma (IFN-gamma) 
      levels, peripheral blood helper T cells 1 (Th1) and Th2 and the recurrence rate 
      of patients after 1 year between two groups. Results showed that after one month 
      of continuous treatment, the total effective rate of the observation group was 
      significantly higher than that of the control group (P <0.05). The symptoms 
      and signs scores and serum IgE levels of the two groups pretreatment (before 
      treatment) were not significantly different (P > 0.05). The symptoms and signs 
      scores and serum IgE levels of the two groups decreased significantly 
      posttreatment (after treatment) (P <0.05), and the observation group was 
      significantly lower than the control group (P <0.05). Pretreatment, the levels 
      of serum inflammatory factors (IL-4, IL-6, IL-13, and IFN-gamma) and the ratio of 
      peripheral blood Th1 and Th2 to CD4+T cells were not significantly different 
      (P> 0.05). After one month of continuous treatment, the levels of serum IL-4, 
      IL-6, IL-13, and the ratio of peripheral blood CD4+IL-4+/CD4+ in the observation 
      group and the control group were significantly reduced and the ratio of 
      CD4+IFN-gamma+/CD4+ was significantly increased (P <0.05). Compared with the 
      control group, those changes were more obvious in the observation group (P 
      <0.05). The one-year recurrence rate of the observation group was 4% (2/50), 
      which was significantly lower than that of the control group, which was 20% 
      (10/50). There was a statistical difference between the two groups (P <0.05). 
      It was concluded that oral desloratadine citrate disodium combined with 
      physiological seawater nasal irrigation can effectively improve the symptoms and 
      signs of intermittent allergic rhinitis and reduce the recurrence rate. This may 
      be related to balancing T cell responses, promoting systemic Th1 responses and 
      inhibiting Th2 responses, and down-regulating inflammatory response.
FAU - Zhang, Yuanyuan
AU  - Zhang Y
AD  - Department of Otolaryngology Head and Neck Surgery, Jining NO.1 People's 
      Hospital, Jining, 272000, China.
FAU - Li, Wei
AU  - Li W
AD  - Department of Otolaryngology Head and Neck Surgery, Jining NO.1 People's 
      Hospital, Jining, 272000, China.
LA  - eng
PT  - Journal Article
DEP - 20200731
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (IL4 protein, human)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-13)
RN  - 0 (Interleukin-6)
RN  - 207137-56-2 (Interleukin-4)
RN  - 2968PHW8QP (Citric Acid)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 7AJO3BO7QN (Loratadine)
RN  - 82115-62-6 (Interferon-gamma)
RN  - FVF865388R (desloratadine)
SB  - IM
MH  - Adult
MH  - CD4-Positive T-Lymphocytes/drug effects/metabolism
MH  - Citric Acid/therapeutic use
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*metabolism
MH  - Interferon-gamma/*metabolism
MH  - Interleukin-13/*metabolism
MH  - Interleukin-4/*metabolism
MH  - Interleukin-6/*metabolism
MH  - Loratadine/*analogs & derivatives/therapeutic use
MH  - Male
MH  - Nasal Lavage/methods
MH  - Rhinitis, Allergic/*drug therapy/metabolism
MH  - Seawater
OTO - NOTNLM
OT  - Physiological sea
OT  - desloratadine citrate disodium
OT  - intermittent allergic rhinitis
OT  - nasal irrigation
EDAT- 2020/10/13 06:00
MHDA- 2021/06/04 06:00
CRDT- 2020/10/12 05:20
PHST- 2020/05/18 00:00 [received]
PHST- 2020/05/19 00:00 [accepted]
PHST- 2020/10/12 05:20 [entrez]
PHST- 2020/10/13 06:00 [pubmed]
PHST- 2021/06/04 06:00 [medline]
PST - epublish
SO  - Cell Mol Biol (Noisy-le-grand). 2020 Jul 31;66(5):54-58.