PMID- 33041085
OWN - NLM
STAT- MEDLINE
DCOM- 20210827
LR  - 20210827
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 81
IP  - 12
DP  - 2020 Dec
TI  - Association of vimentin antibody and other non-HLA antibodies with treated 
      antibody mediated rejection in heart transplant recipients.
PG  - 671-674
LID - S0198-8859(20)30394-3 [pii]
LID - 10.1016/j.humimm.2020.09.003 [doi]
AB  - Non-human leukocyte antigen (HLA) antibodies have been implicated in heart 
      transplantation rejection. However, targets of non-HLA antibodies remain elusive. 
      Here, we utilized a panel of multiplex beads-based assay to determine the 
      specificity of non-HLA antibodies following heart transplantation. We utilized a 
      selected cohort of recipients who did not have HLA donor specific antibodies, but 
      were diagnosed with antibody mediated rejection and treated for antibody mediated 
      rejection. We found the presence of vimentin antibody was associated with treated 
      antibody mediated rejection. Our results suggest that, in heart transplant 
      recipients who are suspected of AMR but in the absence of HLA donor specific 
      antibodies, non-HLA antibodies should be examined.
CI  - Copyright (c) 2020 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Zhang, Xiaohai
AU  - Zhang X
AD  - HLA Laboratory, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los 
      Angeles, CA, United States. Electronic address: xiaohai.zhang@cshs.org.
FAU - Levine, Ryan
AU  - Levine R
AD  - Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United 
      States.
FAU - Patel, Jignesh K
AU  - Patel JK
AD  - Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United 
      States.
FAU - Kittleson, Michelle
AU  - Kittleson M
AD  - Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United 
      States.
FAU - Czer, Lawrence
AU  - Czer L
AD  - Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United 
      States.
FAU - Kobashigawa, Jon A
AU  - Kobashigawa JA
AD  - Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United 
      States.
LA  - eng
PT  - Journal Article
DEP - 20201009
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Autoantibodies)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunologic Factors)
RN  - 0 (VIM protein, human)
RN  - 0 (Vimentin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Autoantibodies/*adverse effects
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Rejection/diagnosis/*immunology/*therapy
MH  - Graft Survival/immunology
MH  - HLA Antigens/*immunology
MH  - Heart Transplantation/*adverse effects
MH  - Histocompatibility Antigens Class I/immunology
MH  - Histocompatibility Antigens Class II/immunology
MH  - Histocompatibility Testing/methods
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Immunologic Factors/*therapeutic use
MH  - Immunotherapy/*methods
MH  - Male
MH  - Middle Aged
MH  - Tissue Donors
MH  - *Transplant Recipients
MH  - Treatment Outcome
MH  - Vimentin/*immunology
OTO - NOTNLM
OT  - Antibody
OT  - HLA
OT  - Non-HLA
OT  - Rejection
OT  - Transplant
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/10/13 06:00
MHDA- 2021/08/28 06:00
CRDT- 2020/10/12 05:23
PHST- 2020/07/01 00:00 [received]
PHST- 2020/09/15 00:00 [revised]
PHST- 2020/09/30 00:00 [accepted]
PHST- 2020/10/13 06:00 [pubmed]
PHST- 2021/08/28 06:00 [medline]
PHST- 2020/10/12 05:23 [entrez]
AID - S0198-8859(20)30394-3 [pii]
AID - 10.1016/j.humimm.2020.09.003 [doi]
PST - ppublish
SO  - Hum Immunol. 2020 Dec;81(12):671-674. doi: 10.1016/j.humimm.2020.09.003. Epub 
      2020 Oct 9.