PMID- 33041991
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201013
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 11
DP  - 2020
TI  - Efficacy of Olfactory and Pareidolia Tests Compared With That of Indicative 
      Biomarkers in Diagnosis of Dementia With Lewy Bodies.
PG  - 540291
LID - 10.3389/fneur.2020.540291 [doi]
LID - 540291
AB  - Purpose: Although olfactory decline and visual hallucinations are useful in 
      distinguishing dementia with Lewy bodies (DLB) from Alzheimer's disease (AD) in a 
      clinical setting, neither is easy to evaluate objectively. The pareidolia test is 
      used to assess susceptibility to visual hallucinations, while in Japan, the Odor 
      Stick Identification Test for the Japanese (OSIT-J) is used to objectively 
      quantify olfactory decline. The present study investigated the efficacy of these 
      olfactory and pareidolia tests in differentiating AD from DLB. Their usefulness 
      was then compared with that of the indicative biomarkers in neuroimaging for a 
      clinical diagnosis of DLB listed in the Fourth Consensus Report of the Dementia 
      with Lewy Bodies Consortium. Methods: A total of 24 probable DLB and 22 probable 
      AD patients were enrolled. All underwent 4 diagnostic procedures: uptake of 
      dopamine transporter in single photon emission computed tomography (DaT-SPECT) 
      and meta-iodobenzylguanidine (MIBG) in myocardial scintigraphy, the pareidolia 
      test, and OSIT-J. The sensitivity, specificity, and accuracy of these methods in 
      differentiating DLB from AD were compared. Results: Sensitivity and specificity 
      in differentiating DLB from AD were 86 and 100% by the heart-to-mediastinum ratio 
      of MIBG uptake; 82 and 96% by the specific binding ratio on DaT-SPECT; 77 and 67% 
      by the combination of OSIT-J and pareidolia test scores; 73 and 62% by the 
      pareidolia test scores; and 77 and 58% by the OSIT-J scores, respectively. 
      Conclusions: The present results suggest that the pareidolia and OSIT-J tests may 
      be considered before resorting to nuclear neuroimaging in the diagnosis of DLB.
CI  - Copyright (c) 2020 Inagawa, Kanetaka, Tsugawa, Sakurai, Serisawa, Shimizu, Sakurai 
      and Hanyu.
FAU - Inagawa, Yuta
AU  - Inagawa Y
AD  - Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
FAU - Kanetaka, Hidekazu
AU  - Kanetaka H
AD  - Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
FAU - Tsugawa, Akito
AU  - Tsugawa A
AD  - Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
FAU - Sakurai, Shu
AU  - Sakurai S
AD  - Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
FAU - Serisawa, Shuntaro
AU  - Serisawa S
AD  - Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
FAU - Shimizu, Soichiro
AU  - Shimizu S
AD  - Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
FAU - Sakurai, Hirofumi
AU  - Sakurai H
AD  - Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
FAU - Hanyu, Haruo
AU  - Hanyu H
AD  - Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20200911
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC7517047
OTO - NOTNLM
OT  - AD
OT  - DAT (dopamine transporter)
OT  - DLB
OT  - MIBG cardiac scintigraphy
OT  - OSIT-J
OT  - dementia with Lewy bodies
OT  - pareidolia test
EDAT- 2020/10/13 06:00
MHDA- 2020/10/13 06:01
PMCR- 2020/09/11
CRDT- 2020/10/12 05:28
PHST- 2020/03/25 00:00 [received]
PHST- 2020/08/14 00:00 [accepted]
PHST- 2020/10/12 05:28 [entrez]
PHST- 2020/10/13 06:00 [pubmed]
PHST- 2020/10/13 06:01 [medline]
PHST- 2020/09/11 00:00 [pmc-release]
AID - 10.3389/fneur.2020.540291 [doi]
PST - epublish
SO  - Front Neurol. 2020 Sep 11;11:540291. doi: 10.3389/fneur.2020.540291. eCollection 
      2020.