PMID- 33043613
OWN - NLM
STAT- MEDLINE
DCOM- 20210705
LR  - 20210705
IS  - 2059-2310 (Electronic)
IS  - 2059-2302 (Print)
IS  - 2059-2302 (Linking)
VI  - 97
IP  - 1
DP  - 2021 Jan
TI  - High-resolution genotyping indicates that children with type 1 diabetes and 
      celiac disease share three HLA class II loci in DRB3, DRB4 and DRB5 genes.
PG  - 44-51
LID - 10.1111/tan.14105 [doi]
AB  - Type 1 diabetes (T1D) and celiac disease (CD) share common genetic loci, mainly 
      within the human leukocyte antigen (HLA) class II complex. Extended genotyping of 
      HLA class II alleles and their potential risk for developing both diseases 
      remains to be studied. The present study compared extended HLA-class II gene 
      polymorphisms in children with T1D, CD, and a subgroup diagnosed with both 
      diseases (T1D w/CD). Next-generation targeted sequencing (NGTS) of HLA-DRB3, 
      DRB4, DRB5, DRB1, DQA1, DQB1, DPA1, and DPB1 alleles from DNA collected from 68 
      T1D, 219 CD, and seven T1D w/CD patients were compared with 636 HLA-genotyped 
      Swedish children from the general population selected as controls. In comparison 
      to controls, the DRB4*01:03:01 allele occurred more frequently in T1D w/CD (odds 
      ratio (OR) = 7.84; 95% confidence interval (95% CI) = (2.24, 34.5), P = 0.0002) 
      and T1D (OR = 3.86; 95% CI, (2.69, 5.55), P = 1.07 x 10(-14) ), respectively. The 
      DRB3*01:01:02 allele occurred more frequently in CD as compared to controls 
      (OR = 7.87; 95% CI, (6.17, 10.03), P = 4.24 x 10(-71) ), but less frequently in 
      T1D (OR = 2.59; 95% CI, (1.76, 3.81), P = 7.29 x 10(-07) ) and T1D w/CD 
      (OR = 0.87; 95% CI, (0.09, 3.96), P </= 0.999). The frequency of the 
      DRB4*01:03:01-DRB1*04:01:01-DQA1*03:01:01-DQB1*03:02:01 (DR4-DQ8) haplotype was 
      higher in T1D w/CD (OR = 12.88; 95% CI (4.35, 38.14) P = 3.75 x 10(-9) ), and 
      moderately higher in T1D (OR = 2.13; 95% CI (1.18, 3.83) P = 0.01) compared with 
      controls, but comparable in CD (OR = 1.45; 95% CI (0.94, 2.21), P = 0.08) and 
      controls. Children with T1D and CD are associated with DRB4*01:03:01, 
      DRB3*01:01:02, and DRB3*02:02:01 of which DRB4*01:03:01 confers the strongest 
      risk allele for developing T1D w/CD.
CI  - (c) 2020 The Authors. HLA: Immune Response Genetics published by John Wiley & Sons 
      Ltd.
FAU - Alshiekh, Shehab
AU  - Alshiekh S
AUID- ORCID: 0000-0002-0536-3535
AD  - Department of Clinical Sciences, Lund University/CRC, Skane University Hospital 
      SUS, Malmo, Sweden.
AD  - Department of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
FAU - Maziarz, Marlena
AU  - Maziarz M
AD  - Department of Clinical Sciences, Lund University/CRC, Skane University Hospital 
      SUS, Malmo, Sweden.
FAU - Geraghty, Daniel E
AU  - Geraghty DE
AD  - Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, 
      Washington, USA.
FAU - Larsson, Helena E
AU  - Larsson HE
AD  - Department of Clinical Sciences, Lund University/CRC, Skane University Hospital 
      SUS, Malmo, Sweden.
FAU - Agardh, Daniel
AU  - Agardh D
AUID- ORCID: 0000-0003-1435-1234
AD  - Department of Clinical Sciences, Lund University/CRC, Skane University Hospital 
      SUS, Malmo, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201109
PL  - England
TA  - HLA
JT  - HLA
JID - 101675570
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - *Celiac Disease/genetics
MH  - Child
MH  - *Diabetes Mellitus, Type 1/genetics
MH  - Gene Frequency
MH  - Genotype
MH  - HLA Antigens
MH  - Haplotypes
MH  - Humans
PMC - PMC7756432
OTO - NOTNLM
OT  - HLA
OT  - celiac disease
OT  - children
OT  - next-generation sequencing
OT  - type 1 diabetes
COIS- The authors have declared no conflicting interests.
EDAT- 2020/10/13 06:00
MHDA- 2021/07/06 06:00
PMCR- 2020/12/23
CRDT- 2020/10/12 05:38
PHST- 2020/06/11 00:00 [received]
PHST- 2020/09/15 00:00 [revised]
PHST- 2020/10/09 00:00 [accepted]
PHST- 2020/10/13 06:00 [pubmed]
PHST- 2021/07/06 06:00 [medline]
PHST- 2020/10/12 05:38 [entrez]
PHST- 2020/12/23 00:00 [pmc-release]
AID - TAN14105 [pii]
AID - 10.1111/tan.14105 [doi]
PST - ppublish
SO  - HLA. 2021 Jan;97(1):44-51. doi: 10.1111/tan.14105. Epub 2020 Nov 9.