PMID- 33044738
OWN - NLM
STAT- MEDLINE
DCOM- 20220222
LR  - 20231002
IS  - 2240-2993 (Electronic)
IS  - 0300-9009 (Linking)
VI  - 121
IP  - 6
DP  - 2021 Dec
TI  - Dyschromatopsia in multiple sclerosis reflects diffuse chronic neurodegeneration 
      beyond anatomical landmarks.
PG  - 1767-1775
LID - 10.1007/s13760-020-01516-x [doi]
AB  - To formulate and validate a dyschromatopsia linear regression model in patients 
      with multiple sclerosis (MS). 64 MS patients (50 to formulate the model and 14 
      for its validation) underwent neurological (Expanded Disability Status Scale, 
      EDSS), color vision (Farnsworth D15 test), and peripapillary retinal nerve fiber 
      layer (pRNFL) and retinal evaluation with spectral-domain optical coherence 
      tomography (SD-OCT). Neuroradiological examination permitted to obtain brain 
      parenchymal fraction (BPF) and cervical spinal cord volume (SC). Ophthalmic 
      parameters were calculated as the average of both non-optic neuritis (ON) eyes, 
      and in case the patient had previous ON, the value of the fellow non-ON eye was 
      taken. The influence of sex, age, disease duration, and history of 
      disease-modifying treatment (first- or second-line DMT) was tested as covariables 
      that could influence color perception. Color confusion index (log CCI) correlated 
      with pRNFL (r =  - 0.322, p = 0.009), ganglion cell layer (GCL, r =  - 0.321, 
      p = 0.01), BPF (r =  - 0.287, p = 0.021), SC volume (r =  - 0.33, p = 0.008), 
      patients' age (r = 0.417, p = 0.001), disease duration (r = 0.371, p = 0.003), 
      and EDSS (r = 0.44, p = 0.001). The following CCI equation was obtained: log 
      (CCI) = 0.316-0.224 BPF - 0.187 SC volume (mm(3)) + 0.226 age (years) + 0.012 
      disease duration (years) - 0.372 GCL (microm). CCI correlates with MS clinical and 
      paraclinical established biomarkers suggesting chronic diffuse neurodegeneration 
      in MS operates at brain, SC, and retina linking all three compartments. Color 
      vision outcome can be calculated through the aforementioned variables for 
      clinical and research purposes.
CI  - (c) 2020. Belgian Neurological Society.
FAU - Barreiro-Gonzalez, Antonio
AU  - Barreiro-Gonzalez A
AUID- ORCID: 0000-0001-6500-6938
AD  - Ophthalmology Department, University and Polytechnic Hospital La Fe, Avenida 
      Fernando Abril Martorell 106, 46026, Valencia, Spain. antoniobarreiro3@gmail.com.
FAU - Sanz, Maria T
AU  - Sanz MT
AUID- ORCID: 0000-0002-7146-8087
AD  - Departamento de Didactica de La Matematica, Universidad de Valencia, Valencia, 
      Spain.
FAU - Carratala-Bosca, Sara
AU  - Carratala-Bosca S
AUID- ORCID: 0000-0003-0021-3041
AD  - Neurology Department, University and Polytechnic Hospital La Fe, Valencia, Spain.
FAU - Perez-Miralles, Francisco
AU  - Perez-Miralles F
AUID- ORCID: 0000-0003-3767-3738
AD  - Neurology Department, University and Polytechnic Hospital La Fe, Valencia, Spain.
FAU - Alcala, Carmen
AU  - Alcala C
AUID- ORCID: 0000-0002-4799-7579
AD  - Neurology Department, University and Polytechnic Hospital La Fe, Valencia, Spain.
FAU - Espana-Gregori, Enrique
AU  - Espana-Gregori E
AUID- ORCID: 0000-0003-0809-8279
AD  - Ophthalmology Department, University and Polytechnic Hospital La Fe, Avenida 
      Fernando Abril Martorell 106, 46026, Valencia, Spain.
AD  - Surgery Department, Faculty of Medicine, University of Valencia, Valencia, Spain.
FAU - Casanova, Bonaventura
AU  - Casanova B
AUID- ORCID: 0000-0003-3806-925X
AD  - Neurology Department, University and Polytechnic Hospital La Fe, Valencia, Spain.
AD  - Medicine Department, Faculty of Medicine, University of Valencia, Valencia, 
      Spain.
LA  - eng
GR  - FIS 17/551/Instituto de Salud Carlos III (ES)/
PT  - Journal Article
PT  - Observational Study
DEP - 20201012
PL  - Italy
TA  - Acta Neurol Belg
JT  - Acta neurologica Belgica
JID - 0247035
SB  - IM
MH  - Adult
MH  - Aged
MH  - Color Perception/*physiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Models, Theoretical
MH  - Multiple Sclerosis/complications/*diagnostic imaging/physiopathology
MH  - Retina/*diagnostic imaging/physiopathology
MH  - Tomography, Optical Coherence/*methods
MH  - Young Adult
OTO - NOTNLM
OT  - Color vision defects
OT  - Magnetic resonance imaging
OT  - Multiple sclerosis
OT  - Neurodegeneration
OT  - Optical coherence tomography
EDAT- 2020/10/13 06:00
MHDA- 2022/02/23 06:00
CRDT- 2020/10/12 12:13
PHST- 2020/04/16 00:00 [received]
PHST- 2020/09/28 00:00 [accepted]
PHST- 2020/10/13 06:00 [pubmed]
PHST- 2022/02/23 06:00 [medline]
PHST- 2020/10/12 12:13 [entrez]
AID - 10.1007/s13760-020-01516-x [pii]
AID - 10.1007/s13760-020-01516-x [doi]
PST - ppublish
SO  - Acta Neurol Belg. 2021 Dec;121(6):1767-1775. doi: 10.1007/s13760-020-01516-x. 
      Epub 2020 Oct 12.