PMID- 33044769
OWN - NLM
STAT- MEDLINE
DCOM- 20210304
LR  - 20210304
IS  - 1522-7278 (Electronic)
IS  - 1520-4081 (Linking)
VI  - 36
IP  - 3
DP  - 2021 Mar
TI  - Ganoderma tsugae suppresses the proliferation of endometrial carcinoma cells via 
      Akt signaling pathway.
PG  - 320-327
LID - 10.1002/tox.23037 [doi]
AB  - Ganoderma is one of the common medicinal mushrooms in traditional Chinese 
      medicine. Previous researches have unveiled the multifaceted biological activity 
      of Ganoderma extract. Ganoderma tsugae has been investigated the potential on 
      curing prostate, colon, lung, epidermoid, breast and ovarian cancers, but not 
      including endometrial cancer. Endometrial cancer is a gynecological malignant 
      tumor with serious drug resistance problem in clinical cancer treatment. This 
      study aimed to demonstrate the first study of Ganoderma on treating endometrial 
      cancer. The Ganoderma tsugae ethanol extract (GTEE) could suppress the 
      proliferation of endometrial cancer cells HEC-1-A, KLE, and AN3 CA. GTEE also 
      induced G1/S phase arrest and mitochondria-mediated apoptosis in endometrial 
      cancer cells. Furthermore, the Akt signaling pathway could be suppressed by GTEE. 
      Therefore, our results suggest for the first time that GTEE has the potential to 
      be an adjuvant therapeutic agent in the treatment of endometrial cancer.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Tsai, Yi-Ting
AU  - Tsai YT
AD  - Department of Biological Science and Technology, College of Life Sciences, China 
      Medical University, Taichung, Taiwan.
FAU - Kuo, Pin-Hung
AU  - Kuo PH
AD  - Department of Biological Science and Technology, College of Life Sciences, China 
      Medical University, Taichung, Taiwan.
FAU - Kuo, Han-Peng
AU  - Kuo HP
AD  - Department of Biological Science and Technology, College of Life Sciences, China 
      Medical University, Taichung, Taiwan.
AD  - Research Unit, Sinphar Group, I-Lan, Taiwan.
FAU - Hsu, Chih-Yu
AU  - Hsu CY
AD  - Department of Biological Science and Technology, College of Life Sciences, China 
      Medical University, Taichung, Taiwan.
FAU - Lee, Yi-Jen
AU  - Lee YJ
AD  - Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, 
      Taiwan.
FAU - Kuo, Chao-Lin
AU  - Kuo CL
AD  - Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, 
      College of Chinese Medicine, China Medical University, Taichung, Taiwan.
FAU - Liu, Jah-Yao
AU  - Liu JY
AD  - Department of Obstetrics and Gynecology, National Defense Medical Center, Taipei, 
      Taiwan.
AD  - Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
FAU - Lee, Shou-Lun
AU  - Lee SL
AUID- ORCID: 0000-0001-8604-3068
AD  - Department of Biological Science and Technology, College of Life Sciences, China 
      Medical University, Taichung, Taiwan.
FAU - Kao, Ming-Ching
AU  - Kao MC
AD  - Department of Biological Science and Technology, College of Life Sciences, China 
      Medical University, Taichung, Taiwan.
AD  - Chinese Medicine Research Center, China Medical University, Taichung, Taiwan.
AD  - Research Center for Chinese Herbal Medicine, China Medical University, Taichung, 
      Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20201012
PL  - United States
TA  - Environ Toxicol
JT  - Environmental toxicology
JID - 100885357
RN  - 0 (Drugs, Chinese Herbal)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Apoptosis/drug effects
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Drugs, Chinese Herbal/*pharmacology/therapeutic use
MH  - Endometrial Neoplasms/*drug therapy
MH  - Female
MH  - *Ganoderma
MH  - Humans
MH  - Medicine, Chinese Traditional
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Signal Transduction/drug effects
OTO - NOTNLM
OT  - Akt signaling pathway
OT  - Ganoderma tsugae
OT  - apoptosis
OT  - cell cycle arrest
OT  - endometrial cancer
OT  - traditional Chinese medicine
EDAT- 2020/10/13 06:00
MHDA- 2021/03/05 06:00
CRDT- 2020/10/12 12:14
PHST- 2020/03/23 00:00 [received]
PHST- 2020/09/15 00:00 [revised]
PHST- 2020/09/22 00:00 [accepted]
PHST- 2020/10/13 06:00 [pubmed]
PHST- 2021/03/05 06:00 [medline]
PHST- 2020/10/12 12:14 [entrez]
AID - 10.1002/tox.23037 [doi]
PST - ppublish
SO  - Environ Toxicol. 2021 Mar;36(3):320-327. doi: 10.1002/tox.23037. Epub 2020 Oct 
      12.