PMID- 3304528
OWN - NLM
STAT- MEDLINE
DCOM- 19870930
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 414
IP  - 2
DP  - 1987 Jun 30
TI  - Effects of L-cysteine-sulphinate and L-aspartate, mixed excitatory amino acid 
      agonists, on the membrane potential of cat caudate neurons.
PG  - 330-8
AB  - Responses evoked by L-cysteine-sulphinate (L-CSA) and L-aspartate (L-Asp) were 
      recorded with intracellular electrodes from caudate neurons in halothane 
      anesthetized cats. L-CSA and L-Asp were applied microiontophoretically to caudate 
      cells and their effects on membrane and action potentials, as well as on 
      cortically evoked synaptic potentials were evaluated. L-CSA and L-Asp induced 
      depolarizations accompanied by regular firing resembling kainate (KA)- or 
      quisqualate (QUIS)-induced excitation patterns (type 1) in 82% and 72% of the 
      recorded neurons, respectively, and a mixed pattern consisting of a 
      N-methyl-D-aspartate (NMDA)-like excitation (type 2) followed by a regular type 1 
      pattern in the remaining cells. In about a quarter of the cells the effects of 
      L-CSA and L-Asp, but not those of KA or QUIS, were partially antagonized by 
      2-amino-7-phosphonoheptanoate (AP-7), a specific NMDA receptor antagonist. 
      Kynurenate, a broad spectrum excitatory amino acid antagonist, blocked responses 
      elicited by either L-CSA or QUIS. The actions of L-CSA and L-Asp on the firing 
      pattern and membrane potential of cat caudate neurons in situ provide evidence in 
      favor of their mixed agonist nature with respect to NMDA and non-NMDA excitatory 
      amino acid receptors.
FAU - Turski, W A
AU  - Turski WA
FAU - Herrling, P L
AU  - Herrling PL
FAU - Do, K Q
AU  - Do KQ
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Amino Acids)
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Oxadiazoles)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
RN  - 8OC22C1B99 (Quisqualic Acid)
RN  - K848JZ4886 (Cysteine)
RN  - P34K80CUSM (2-amino-7-phosphonoheptanoic acid)
RN  - SIV03811UC (Kainic Acid)
RN  - UZY4HYK4ZX (cysteine sulfinic acid)
SB  - IM
MH  - *2-Amino-5-phosphonovalerate/*analogs & derivatives
MH  - Action Potentials/drug effects
MH  - Amino Acids/*pharmacology
MH  - Animals
MH  - Aspartic Acid/analogs & derivatives/*pharmacology
MH  - Cats
MH  - Caudate Nucleus/*drug effects/physiology
MH  - Cysteine/*analogs & derivatives/pharmacology
MH  - Female
MH  - Kainic Acid/pharmacology
MH  - Male
MH  - Membrane Potentials/drug effects
MH  - N-Methylaspartate
MH  - Neurotransmitter Agents
MH  - Oxadiazoles/pharmacology
MH  - Quisqualic Acid
EDAT- 1987/06/30 00:00
MHDA- 1987/06/30 00:01
CRDT- 1987/06/30 00:00
PHST- 1987/06/30 00:00 [pubmed]
PHST- 1987/06/30 00:01 [medline]
PHST- 1987/06/30 00:00 [entrez]
AID - 0006-8993(87)90014-X [pii]
AID - 10.1016/0006-8993(87)90014-x [doi]
PST - ppublish
SO  - Brain Res. 1987 Jun 30;414(2):330-8. doi: 10.1016/0006-8993(87)90014-x.