PMID- 3304529
OWN - NLM
STAT- MEDLINE
DCOM- 19871015
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 415
IP  - 1
DP  - 1987 Jul 7
TI  - Accessory olfactory bulb transplants correct hypogonadism in mutant mice.
PG  - 158-62
AB  - Transplantation of normal fetal gonadotropin-releasing hormone (GnRH) neurons 
      from the accessory olfactory bulb (AOB) to the third ventricle of GnRH-deficient 
      adult mutant mice reverses the genetically determined reduction in pituitary 
      hormones and poorly developed gonads. The transplanted heterotopic AOB neurons 
      adapt their morphology and secretory functions to what is observed with preoptic 
      GnRH neurons when transplanted into deficient mice and in the normal intact 
      mature animal. This suggests the presence of median eminence trophic factors 
      affecting the growth, terminal sprouting, and functional behavior of the 
      transplanted neurons.
FAU - Perlow, M J
AU  - Perlow MJ
FAU - Kokoris, G
AU  - Kokoris G
FAU - Gibson, M J
AU  - Gibson MJ
FAU - Silverman, A J
AU  - Silverman AJ
FAU - Kreiger, D T
AU  - Kreiger DT
FAU - Zimmerman, E A
AU  - Zimmerman EA
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Pituitary Hormone-Releasing Hormones)
RN  - 9002-67-9 (Luteinizing Hormone)
SB  - IM
MH  - Animals
MH  - Cerebral Ventricles/metabolism/*physiopathology/surgery
MH  - Fetus
MH  - Graft Survival
MH  - Hypogonadism/*physiopathology
MH  - Hypothalamus/metabolism/physiopathology
MH  - Luteinizing Hormone/blood
MH  - Male
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Olfactory Bulb/physiopathology/*transplantation
MH  - Organ Size
MH  - Pituitary Gland/metabolism
MH  - Pituitary Hormone-Releasing Hormones/*physiology
MH  - Testis/pathology
EDAT- 1987/07/07 00:00
MHDA- 1987/07/07 00:01
CRDT- 1987/07/07 00:00
PHST- 1987/07/07 00:00 [pubmed]
PHST- 1987/07/07 00:01 [medline]
PHST- 1987/07/07 00:00 [entrez]
AID - 0006-8993(87)90280-0 [pii]
AID - 10.1016/0006-8993(87)90280-0 [doi]
PST - ppublish
SO  - Brain Res. 1987 Jul 7;415(1):158-62. doi: 10.1016/0006-8993(87)90280-0.