PMID- 33045585
OWN - NLM
STAT- MEDLINE
DCOM- 20201229
LR  - 20201229
IS  - 1873-7072 (Electronic)
IS  - 0308-8146 (Linking)
VI  - 341
IP  - Pt 2
DP  - 2021 Mar 30
TI  - Development of an analytical method for the quantitative determination of 
      multi-class nutrients in different food matrices by solid-phase extraction and 
      liquid chromatography-tandem mass spectrometry using design of experiments.
PG  - 128173
LID - S0308-8146(20)32035-5 [pii]
LID - 10.1016/j.foodchem.2020.128173 [doi]
AB  - A simple and rapid analytical method based on solid-phase extraction (SPE) 
      followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) with the 
      aid of design of experiments (DOE) approach was developed and validated for 
      simultaneous determination of multi-class nutrients (water- and fat-soluble 
      vitamins and flavonoids) in various food matrices (vegetables, fruits, and 
      cereals). The factors affecting the SPE method were optimized using DOE tools. 
      The separation was achieved in 13 min using the C18 column by gradient LC 
      programme. The SPE-LC-MS/MS method was validated in terms of limit of detection 
      (1.29-29.17 ng/g), linearity range (25-1000 ng/g), coefficient of determination 
      (0.993-0.999) and recovery (72.53-104.24%) for multi-class nutrients in different 
      food samples. Inter- and intra-day precision were evaluated and found to be 
      within acceptable range. The developed method finds extensive application in the 
      routine analysis of multi-class nutrients in various food matrices.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Arvapally, Manasa
AU  - Arvapally M
AD  - Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India; 
      Analytical & Structural Chemistry Department, CSIR-Indian Institute of Chemical 
      Technology, Tarnaka, Uppal Road, Hyderabad 500007, India.
FAU - Asati, Ankita
AU  - Asati A
AD  - Analytical & Structural Chemistry Department, CSIR-Indian Institute of Chemical 
      Technology, Tarnaka, Uppal Road, Hyderabad 500007, India.
FAU - Nagendla, Narendra Kumar
AU  - Nagendla NK
AD  - Analytical & Structural Chemistry Department, CSIR-Indian Institute of Chemical 
      Technology, Tarnaka, Uppal Road, Hyderabad 500007, India.
FAU - Mudiam, Mohana Krishna Reddy
AU  - Mudiam MKR
AD  - Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India; 
      Analytical & Structural Chemistry Department, CSIR-Indian Institute of Chemical 
      Technology, Tarnaka, Uppal Road, Hyderabad 500007, India. Electronic address: 
      mmudiam@iict.res.in.
LA  - eng
PT  - Journal Article
DEP - 20200924
PL  - England
TA  - Food Chem
JT  - Food chemistry
JID - 7702639
RN  - 0 (Flavonoids)
RN  - 0 (Vitamins)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Chromatography, Liquid/*methods
MH  - Edible Grain/chemistry
MH  - Flavonoids/analysis
MH  - Food Analysis/*methods
MH  - Fruit/chemistry
MH  - Limit of Detection
MH  - Nutrients/*analysis
MH  - Reproducibility of Results
MH  - Solid Phase Extraction/instrumentation/*methods
MH  - Tandem Mass Spectrometry/*methods
MH  - Vegetables/chemistry
MH  - Vitamins/analysis
MH  - Water/chemistry
OTO - NOTNLM
OT  - Biotin (171548)
OT  - Calciferol (5280793)
OT  - Curcumin (969516)
OT  - Cyanocobalamin (44176380)
OT  - Design of experiments
OT  - Folic Acid (135398658)
OT  - Fruits, vegetables & cereals
OT  - Hesperetin (72281)
OT  - LC-MS/MS
OT  - Multi-class nutrients
OT  - Naringenin (932)
OT  - Naringin (442428)
OT  - Niacin (938)
OT  - Pantothenic Acid (6613)
OT  - Pyridoxine (1054)
OT  - Quercetin (5280343)
OT  - Riboflavin (493570)
OT  - Solid-phase extraction
OT  - Tocopherol (86472)
EDAT- 2020/10/13 06:00
MHDA- 2020/12/30 06:00
CRDT- 2020/10/12 20:12
PHST- 2020/02/03 00:00 [received]
PHST- 2020/09/19 00:00 [revised]
PHST- 2020/09/21 00:00 [accepted]
PHST- 2020/10/13 06:00 [pubmed]
PHST- 2020/12/30 06:00 [medline]
PHST- 2020/10/12 20:12 [entrez]
AID - S0308-8146(20)32035-5 [pii]
AID - 10.1016/j.foodchem.2020.128173 [doi]
PST - ppublish
SO  - Food Chem. 2021 Mar 30;341(Pt 2):128173. doi: 10.1016/j.foodchem.2020.128173. 
      Epub 2020 Sep 24.