PMID- 33046299
OWN - NLM
STAT- MEDLINE
DCOM- 20210830
LR  - 20210830
IS  - 1532-8171 (Electronic)
IS  - 0735-6757 (Linking)
VI  - 45
DP  - 2021 Jul
TI  - Novel biomarkers of oxidative stress as predictive indicators of neurological 
      outcome after out-of-hospital cardiopulmonary arrest.
PG  - 264-268
LID - S0735-6757(20)30752-X [pii]
LID - 10.1016/j.ajem.2020.08.059 [doi]
AB  - AIM: Among patients of out-of-hospital cardiopulmonary arrest (OHCPA), only 6% 
      resume their pre-OHCPA social life. The prediction of neurological outcome 
      immediately after the return of spontaneous circulation (ROSC) is urgently needed 
      in OHCPA patients. Novel biomarkers, biological antioxidant potential (BAP), and 
      diacron-reactive oxygen metabolites (d-ROM) are potential predictors of 
      neurological outcome after OHCPA. This study was conducted to evaluate the 
      utility of BAP and d-ROM in the prediction of patient outcomes after OHCPA. 
      METHODS: Blood samples were collected immediately after OHCPA patients were 
      admitted to our hospital between May 2011 and June 2013. BAP and d-ROM 
      concentrations were measured with the simple equipment FRAS4  (Wismerll, Italy). 
      Their association with favorable (cerebral performance category [CPC], 1 and 2) 
      and unfavorable (CPC 3-5) clinical outcomes was compared. BAP and d-ROM values 
      from 23 normal healthy volunteers (HV) were used as controls. RESULTS: Overall, 
      152 OHCPA patients were included, and 26 patients achieved ROSC. Eleven died 
      during hospitalization were allocated a CPC of 5 and remaining patients were 
      discharged or transported (CPC 1: n = 4; CPC 2: n = 6; CPC 3: n = 3; CPC 4: 
      n = 2; CPC 5: n = 11). The receiver operating characteristics curve of d-ROM and 
      BAP for predicting survival 28 days after OHCPA was 0.596 and 0.834, 
      respectively. Patients without ROSC had significantly higher BAP than HV and 
      patients with ROSC (p < 0.001). A significant correlation was evident between BAP 
      and the time to ROSC (r = 0.641, p < 0.01). CONCLUSION: Oxidative stress, 
      indicated by BAP on admission, strongly correlated with the neurological outcome 
      after OHCPA.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Ishikawa, Kouhei
AU  - Ishikawa K
AD  - Department of Emergency and Critical Care Medicine, Juntendo University Urayasu 
      Hospital, Chiba, Japan.
FAU - Inoue, Yoshiaki
AU  - Inoue Y
AD  - Department of Emergency and Critical Care Medicine, University of Tsukuba, 
      Ibaraki, Japan.
FAU - Sumi, Yuka
AU  - Sumi Y
AD  - Department of Emergency and Critical Care Medicine, Juntendo University Urayasu 
      Hospital, Chiba, Japan.
FAU - Kondo, Yutaka
AU  - Kondo Y
AD  - Department of Emergency and Critical Care Medicine, Juntendo University Urayasu 
      Hospital, Chiba, Japan. Electronic address: kondokondou-2000@umin.ac.jp.
FAU - Okamoto, Ken
AU  - Okamoto K
AD  - Department of Emergency and Critical Care Medicine, Juntendo University Urayasu 
      Hospital, Chiba, Japan.
FAU - Tanaka, Hiroshi
AU  - Tanaka H
AD  - Department of Emergency and Critical Care Medicine, Juntendo University Urayasu 
      Hospital, Chiba, Japan.
LA  - eng
PT  - Journal Article
DEP - 20200901
PL  - United States
TA  - Am J Emerg Med
JT  - The American journal of emergency medicine
JID - 8309942
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Aged
MH  - Antioxidants/metabolism
MH  - Biomarkers/*blood
MH  - Cardiopulmonary Resuscitation
MH  - Central Nervous System Diseases/*etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Out-of-Hospital Cardiac Arrest/*blood/*complications
MH  - *Oxidative Stress
MH  - Reactive Oxygen Species/blood
OTO - NOTNLM
OT  - Cardiopulmonary arrest
OT  - Central nervous system
OT  - Circulation
OT  - ER
COIS- Declaration of competing interest Authors declare no conflicts of interest for 
      this article.
EDAT- 2020/10/14 06:00
MHDA- 2021/08/31 06:00
CRDT- 2020/10/13 05:31
PHST- 2020/05/07 00:00 [received]
PHST- 2020/07/13 00:00 [revised]
PHST- 2020/08/19 00:00 [accepted]
PHST- 2020/10/14 06:00 [pubmed]
PHST- 2021/08/31 06:00 [medline]
PHST- 2020/10/13 05:31 [entrez]
AID - S0735-6757(20)30752-X [pii]
AID - 10.1016/j.ajem.2020.08.059 [doi]
PST - ppublish
SO  - Am J Emerg Med. 2021 Jul;45:264-268. doi: 10.1016/j.ajem.2020.08.059. Epub 2020 
      Sep 1.