PMID- 33048064
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20211015
IS  - 1479-6813 (Electronic)
IS  - 0952-5041 (Linking)
VI  - 65
IP  - 4
DP  - 2020 Nov
TI  - NETosis contributes to the pathogenesis of diabetes and its complications.
PG  - R65-R76
LID - JME-20-0128 [pii]
LID - 10.1530/JME-20-0128 [doi]
AB  - NETosis, a novel form of neutrophil-related cell death, acts as a major regulator 
      of diabetes and diabetes-associated complications. In this review, we show that 
      the extrusion of neutrophil extracellular traps, termed NETs, plays an important 
      role in the pathogenesis of type 1 diabetes mellitus (T1DM), type 2 diabetes 
      mellitus (T2DM), and diabetes-induced complications. In T1DM, beta-cell death 
      induces the sequestration of neutrophils in the pancreas and seems to be 
      correlated with increased NETosis. In T2DM patients, products of NETs release are 
      significantly elevated. Increased levels of dsDNA are correlated with the 
      presence of cardiovascular disease and diabetic kidney disease, further 
      supporting the role of NETosis in the pathogenesis of other diabetes-induced 
      complications such as impaired wound healing and diabetic retinopathy. NETosis is 
      induced by high glucose through incompletely understood mechanisms, but it also 
      appears to be elevated in patients with diabetes who have tightly controlled 
      glucose levels. We hypothesize that hyperglycemia worsens the already elevated 
      baseline of NETosis in diabetic patients to further increase its detrimental 
      effects.
FAU - Njeim, Rachel
AU  - Njeim R
AD  - Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of 
      Medicine and Medical Center, American University of Beirut, Beirut, Lebanon.
AD  - AUB Diabetes, American University of Beirut, Beirut, Lebanon.
FAU - Azar, William S
AU  - Azar WS
AUID- ORCID: 0000-0003-0682-3465
AD  - Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of 
      Medicine and Medical Center, American University of Beirut, Beirut, Lebanon.
AD  - AUB Diabetes, American University of Beirut, Beirut, Lebanon.
AD  - Department of Physiology and Biophysics, Georgetown University Medical Center, 
      Washington, District of Colombia, USA.
FAU - Fares, Angie H
AU  - Fares AH
AD  - Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of 
      Medicine and Medical Center, American University of Beirut, Beirut, Lebanon.
AD  - AUB Diabetes, American University of Beirut, Beirut, Lebanon.
FAU - Azar, Sami T
AU  - Azar ST
AD  - AUB Diabetes, American University of Beirut, Beirut, Lebanon.
AD  - Department of Internal Medicine, Faculty of Medicine and Medical Center, American 
      University of Beirut, Beirut, Lebanon.
FAU - Kfoury Kassouf, Hala
AU  - Kfoury Kassouf H
AD  - Department of Pathology and Laboratory Medicine, Faculty of Medicine and Medical 
      Center, American University of Beirut, Beirut, Lebanon.
FAU - Eid, Assaad A
AU  - Eid AA
AD  - Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of 
      Medicine and Medical Center, American University of Beirut, Beirut, Lebanon.
AD  - AUB Diabetes, American University of Beirut, Beirut, Lebanon.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Mol Endocrinol
JT  - Journal of molecular endocrinology
JID - 8902617
RN  - 0 (Biomarkers)
RN  - EC 1.6.3.- (NADPH Oxidases)
SB  - IM
MH  - Animals
MH  - Biomarkers
MH  - Diabetes Complications/*etiology/*metabolism
MH  - Diabetes Mellitus/*etiology/*metabolism
MH  - Disease Susceptibility
MH  - Extracellular Traps/genetics/*immunology/*metabolism
MH  - Humans
MH  - NADPH Oxidases/genetics/metabolism
MH  - Neutrophils/*immunology/*metabolism/pathology
OTO - NOTNLM
OT  - NADPH oxidases
OT  - NETosis
OT  - diabetes mellitus
OT  - diabetes-induced complications
OT  - neutrophil extracellular traps
EDAT- 2020/10/14 06:00
MHDA- 2021/10/16 06:00
CRDT- 2020/10/13 12:11
PHST- 2020/07/30 00:00 [received]
PHST- 2020/09/03 00:00 [accepted]
PHST- 2020/10/13 12:11 [entrez]
PHST- 2020/10/14 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
AID - JME-20-0128 [pii]
AID - 10.1530/JME-20-0128 [doi]
PST - ppublish
SO  - J Mol Endocrinol. 2020 Nov;65(4):R65-R76. doi: 10.1530/JME-20-0128.