PMID- 3304918
OWN - NLM
STAT- MEDLINE
DCOM- 19871021
LR  - 20131121
IS  - 0378-6501 (Print)
IS  - 0378-6501 (Linking)
VI  - 13
IP  - 4
DP  - 1987
TI  - Susceptibility in vitro of gram-positive aerobe and anaerobe bacteria to 
      ofloxacin.
PG  - 213-7
AB  - Ofloxacin is a new fluoroquinolone derivative active against Gram-positive and 
      Gram-negative bacteria including obligate anaerobes. In this study the in vitro 
      activity of ofloxacin was evaluated against 325 Gram-positive organisms freshly 
      isolated from clinical specimens, in comparison with that of ampicillin, 
      erythromycin, clindamycin and ceftazidime. Susceptibility tests indicated that 
      the MIC90 was 2 mg/l (range 0.25-2) against both methicillin-susceptible (MS) and 
      methicillin-resistant (MR) Staphylococcus aureus. A value of 2 mg/l (range 0.5-4) 
      was also found for all other staphylococci. The MIC of ofloxacin was 8 mg/l for 
      90% of Streptococcus faecalis (range 1-16), Str. faecium (range 2-8) and members 
      of JK group (range 0.5-16). Propionibacterium acnes strains were all inhibited by 
      2 mg/l and 90% of Clostridia spp. (range 2-16) by 8 mg/l. Ofloxacin activity 
      compared favourably with that of ampicillin, erythromycin, clindamycin and 
      ceftazidime determined on the same isolates. MBC and time-kill studies indicated 
      that this compound is rapidly bactericidal against enterococci. The great 
      intrinsic activity against MS and MR staphylococci, refractory enterococci and JK 
      bacteria may make ofloxacin a useful adjunct to the therapeutic arsenal.
FAU - Debbia, E
AU  - Debbia E
FAU - Mannelli, S
AU  - Mannelli S
FAU - Gianrossi, G
AU  - Gianrossi G
FAU - Schito, G C
AU  - Schito GC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Switzerland
TA  - Drugs Exp Clin Res
JT  - Drugs under experimental and clinical research
JID - 7802135
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Oxazines)
RN  - 3U02EL437C (Clindamycin)
RN  - 63937KV33D (Erythromycin)
RN  - 7C782967RD (Ampicillin)
RN  - 9M416Z9QNR (Ceftazidime)
RN  - A4P49JAZ9H (Ofloxacin)
SB  - IM
MH  - Ampicillin/pharmacology
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Ceftazidime/pharmacology
MH  - Clindamycin/pharmacology
MH  - Erythromycin/pharmacology
MH  - Gram-Positive Bacteria/*drug effects
MH  - Humans
MH  - Microbial Sensitivity Tests
MH  - Ofloxacin
MH  - Oxazines/*pharmacology
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
PST - ppublish
SO  - Drugs Exp Clin Res. 1987;13(4):213-7.