PMID- 33049983
OWN - NLM
STAT- MEDLINE
DCOM- 20210308
LR  - 20210308
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 19
DP  - 2020 Oct 8
TI  - Pericyte-Endothelial Interactions in the Retinal Microvasculature.
LID - 10.3390/ijms21197413 [doi]
LID - 7413
AB  - Retinal microvasculature is crucial for the visual function of the neural retina. 
      Pericytes and endothelial cells (ECs) are the two main cellular constituents in 
      the retinal microvessels. Formation, maturation, and stabilization of the 
      micro-vasculatures require pericyte-endothelial interactions, which are perturbed 
      in many retinal vascular disorders, such as retinopathy of prematurity, retinal 
      vein occlusion, and diabetic retinopathy. Understanding the cellular and 
      molecular mechanisms of pericyte-endothelial interaction and perturbation can 
      facilitate the design of therapeutic intervention for the prevention and 
      treatment of retinal vascular disorders. Pericyte-endothelial interactions are 
      indispensable for the integrity and functionality of retinal neurovascular unit 
      (NVU), including vascular cells, retinal neurons, and glial cells. The essential 
      autocrine and paracrine signaling pathways, such as Vascular endothelial growth 
      factor (VEGF), Platelet-derived growth factor subunit B (PDGFB), Notch, 
      Angipointein, Norrin, and Transforming growth factor-beta (TGF-beta), have been well 
      characterized for the regulation of pericyte-endothelial interactions in the 
      neo-vessel formation processes (vasculogenesis and angiogenesis) during embryonic 
      development. They also play a vital role in stabilizing and remodeling mature 
      vasculature under pathological conditions. Awry signals, aberrant metabolisms, 
      and pathological conditions, such as oxidative stress and inflammation, can 
      disrupt the communication between pericytes and endothelial cells, thereby 
      resulting in the breakdown of the blood-retinal barrier (BRB) and other 
      microangiopathies. The emerging evidence supports extracellular exosomes' roles 
      in the (mis)communications between the two cell types. This review summarizes the 
      essential knowledge and updates about new advancements in pericyte-EC interaction 
      and communication, emphasizing the retinal microvasculature.
FAU - Huang, Hu
AU  - Huang H
AD  - Department of Ophthalmology, School of Medicine, Mason Eye Institute, University 
      of Missouri, One Hospital Drive, MA102C, Columbia, MO 65212, USA.
LA  - eng
GR  - R01 EY027824/EY/NEI NIH HHS/United States
GR  - EY027824/NH/NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20201008
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Animals
MH  - Blood-Retinal Barrier/metabolism
MH  - Endothelial Cells/*metabolism
MH  - Exosomes/metabolism
MH  - Humans
MH  - Microvessels/*metabolism
MH  - Models, Animal
MH  - Neovascularization, Physiologic
MH  - Pericytes/*metabolism
MH  - Retina/metabolism
MH  - Retinal Diseases/metabolism
MH  - Retinal Vessels/*metabolism
MH  - *Signal Transduction
PMC - PMC7582747
OTO - NOTNLM
OT  - blood-retinal barrier
OT  - diabetic retinopathy
OT  - endothelial cells
OT  - exosomes
OT  - microvasculature
OT  - pericytes
OT  - placental growth factor
OT  - retina
OT  - vessel organoids
COIS- The authors declare that they have no conflicts of interest with this article's 
      content.
EDAT- 2020/10/15 06:00
MHDA- 2021/03/09 06:00
PMCR- 2020/10/01
CRDT- 2020/10/14 01:02
PHST- 2020/09/04 00:00 [received]
PHST- 2020/09/25 00:00 [revised]
PHST- 2020/09/30 00:00 [accepted]
PHST- 2020/10/14 01:02 [entrez]
PHST- 2020/10/15 06:00 [pubmed]
PHST- 2021/03/09 06:00 [medline]
PHST- 2020/10/01 00:00 [pmc-release]
AID - ijms21197413 [pii]
AID - ijms-21-07413 [pii]
AID - 10.3390/ijms21197413 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Oct 8;21(19):7413. doi: 10.3390/ijms21197413.