PMID- 33050362
OWN - NLM
STAT- MEDLINE
DCOM- 20201204
LR  - 20201214
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 17
IP  - 20
DP  - 2020 Oct 10
TI  - Effects of Hyperbaric Oxygen Therapy on Inflammation, Oxidative/Antioxidant 
      Balance, and Muscle Damage after Acute Exercise in Normobaric, Normoxic and 
      Hypobaric, Hypoxic Environments: A Pilot Study.
LID - 10.3390/ijerph17207377 [doi]
LID - 7377
AB  - The purpose of this study was to investigate the effects of hyperbaric oxygen 
      therapy (HBOT) on inflammation, the oxidative/antioxidant balance, and muscle 
      damage after acute exercise in normobaric, normoxic (NN) and hypobaric, hypoxic 
      (HH) environments. Eighteen healthy males were selected and randomly assigned to 
      three groups: exercise in NN conditions (NN group, n = 6), HBOT treatment after 
      exercise in NN conditions (HNN group, n = 6), and HBOT treatment after exercise 
      in HH conditions (HHH group, n = 6). All subjects performed treadmill running for 
      60 min at 75-80% maximum heart rate (HRmax) exercise intensity under each 
      condition. The HBOT treatments consisted of breathing 100% oxygen at 2.5 
      atmosphere absolute (ATA) for 60 min. Blood samples were collected before 
      exercise (BE), after exercise (AE), and after HBOT (AH) to examine inflammation 
      (fibrinogen, interleukin-6 [IL-6], and tumor necrosis factor-alpha (TNF-alpha)), the 
      oxidative/antioxidant balance (derivatives of reactive oxygen metabolites 
      (d-ROMs) and the biological antioxidant potential (BAP)), and muscle damage 
      (creatine kinase (CK) and lactate dehydrogenase (LDH)). Plasma fibrinogen, serum 
      IL-6, CK, and LDH levels were significantly increased AE compared to BE in all 
      groups (p < 0.05). Plasma fibrinogen levels were significantly decreased AH 
      compared to AE in all groups (p < 0.05), and the HNN group had a significantly 
      lower AH compared to BE (p < 0.05). Serum IL-6 levels were significantly 
      decreased AH compared to AE in the HNN and HHH groups (p < 0.05). Serum CK levels 
      were significantly decreased AH compared to AE in the HHH group (p < 0.05). Serum 
      LDH levels were significantly decreased AH compared to AE in the HNN and HHH 
      groups (p < 0.05), and the NN and HNN groups had significantly higher AH serum 
      LDH levels compared to BE (p < 0.05). These results suggest that acute exercise 
      in both the NN and HH environments could induce temporary inflammatory responses 
      and muscle damage, whereas HBOT treatment may be effective in alleviating 
      exercise-induced inflammatory responses and muscle damage.
FAU - Woo, Jinhee
AU  - Woo J
AD  - Department of Physical Education, College of Arts and Physical Education, Dong-A 
      University, Busan 49315, Korea.
FAU - Min, Jae-Hee
AU  - Min JH
AD  - Department of Physical Education, College of Arts and Physical Education, Dong-A 
      University, Busan 49315, Korea.
FAU - Lee, Yul-Hyo
AU  - Lee YH
AD  - Department of Taekwondo, Youngsan University, Yangsan-si 50510, Korea.
FAU - Roh, Hee-Tae
AU  - Roh HT
AUID- ORCID: 0000-0002-3586-1666
AD  - Department of Physical Education, College of Arts and Physical Education, Dong-A 
      University, Busan 49315, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201010
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Antioxidants)
SB  - IM
MH  - *Antioxidants/metabolism
MH  - *Exercise/physiology
MH  - Humans
MH  - *Hyperbaric Oxygenation
MH  - *Inflammation/blood/therapy
MH  - Male
MH  - *Muscular Diseases/blood/therapy
MH  - *Oxidative Stress
MH  - Pilot Projects
MH  - Random Allocation
PMC - PMC7601270
OTO - NOTNLM
OT  - acute exercise
OT  - healthy young individuals
OT  - hyperbaric oxygen therapy
OT  - hypoxia
OT  - inflammation
OT  - muscle damage
OT  - oxidative stress
COIS- The authors declare no conflict of interest.
EDAT- 2020/10/15 06:00
MHDA- 2020/12/15 06:00
PMCR- 2020/10/01
CRDT- 2020/10/14 01:04
PHST- 2020/09/14 00:00 [received]
PHST- 2020/10/06 00:00 [revised]
PHST- 2020/10/07 00:00 [accepted]
PHST- 2020/10/14 01:04 [entrez]
PHST- 2020/10/15 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/10/01 00:00 [pmc-release]
AID - ijerph17207377 [pii]
AID - ijerph-17-07377 [pii]
AID - 10.3390/ijerph17207377 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2020 Oct 10;17(20):7377. doi: 
      10.3390/ijerph17207377.