PMID- 33050407
OWN - NLM
STAT- MEDLINE
DCOM- 20210907
LR  - 20230919
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 10
IP  - 10
DP  - 2020 Oct 10
TI  - Bullous Pemphigoid: Trigger and Predisposing Factors.
LID - 10.3390/biom10101432 [doi]
LID - 1432
AB  - Bullous pemphigoid (BP) is the most frequent autoimmune subepidermal blistering 
      disease provoked by autoantibodies directed against two hemidesmosomal proteins: 
      BP180 and BP230. Its pathogenesis depends on the interaction between predisposing 
      factors, such as human leukocyte antigen (HLA) genes, comorbidities, aging, and 
      trigger factors. Several trigger factors, such as drugs, thermal or electrical 
      burns, surgical procedures, trauma, ultraviolet irradiation, radiotherapy, 
      chemical preparations, transplants, and infections may induce or exacerbate BP 
      disease. Identification of predisposing and trigger factors can increase the 
      understanding of BP pathogenesis. Furthermore, an accurate anamnesis focused on 
      the recognition of a possible trigger factor can improve prognosis by promptly 
      removing it.
FAU - Moro, Francesco
AU  - Moro F
AUID- ORCID: 0000-0003-0031-941X
FAU - Fania, Luca
AU  - Fania L
FAU - Sinagra, Jo Linda Maria
AU  - Sinagra JLM
AD  - IDI-IRCCS, via dei Monti di Creta 104, 00167 Rome, Italy.
FAU - Salemme, Adele
AU  - Salemme A
AD  - IDI-IRCCS, via dei Monti di Creta 104, 00167 Rome, Italy.
FAU - Di Zenzo, Giovanni
AU  - Di Zenzo G
AD  - IDI-IRCCS, via dei Monti di Creta 104, 00167 Rome, Italy.
LA  - eng
GR  - "Progetto Ricerca Corrente - 2019" and "Ricerca Finalizzata-2020"/Italian 
      Ministry of Health, Rome, Italy/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201010
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Causality
MH  - Comorbidity
MH  - Disease Susceptibility
MH  - Drug-Related Side Effects and Adverse 
      Reactions/complications/diagnosis/epidemiology
MH  - Gene-Environment Interaction
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Infections/complications/epidemiology
MH  - Pemphigoid, Bullous/diagnosis/*epidemiology/*etiology
MH  - Prognosis
MH  - Risk Factors
PMC - PMC7600534
OTO - NOTNLM
OT  - autoimmune bullous disease
OT  - bullous pemphigoid
OT  - etiopathogenesis
OT  - predisposing factors
OT  - trigger factors
COIS- The authors declare no conflicts of interest.
EDAT- 2020/10/15 06:00
MHDA- 2021/09/08 06:00
PMCR- 2020/10/10
CRDT- 2020/10/14 01:04
PHST- 2020/09/07 00:00 [received]
PHST- 2020/10/01 00:00 [revised]
PHST- 2020/10/08 00:00 [accepted]
PHST- 2020/10/14 01:04 [entrez]
PHST- 2020/10/15 06:00 [pubmed]
PHST- 2021/09/08 06:00 [medline]
PHST- 2020/10/10 00:00 [pmc-release]
AID - biom10101432 [pii]
AID - biomolecules-10-01432 [pii]
AID - 10.3390/biom10101432 [doi]
PST - epublish
SO  - Biomolecules. 2020 Oct 10;10(10):1432. doi: 10.3390/biom10101432.