PMID- 33051817
OWN - NLM
STAT- MEDLINE
DCOM- 20210728
LR  - 20211203
IS  - 1995-8218 (Electronic)
IS  - 1673-7067 (Print)
IS  - 1995-8218 (Linking)
VI  - 36
IP  - 12
DP  - 2020 Dec
TI  - Genetic Evidence that Dorsal Spinal Oligodendrocyte Progenitor Cells are Capable 
      of Myelinating Ventral Axons Effectively in Mice.
PG  - 1474-1483
LID - 10.1007/s12264-020-00593-5 [doi]
AB  - In the developing spinal cord, the majority of oligodendrocyte progenitor cells 
      (OPCs) are induced in the ventral neuroepithelium under the control of the Sonic 
      Hedgehog (Shh) signaling pathway, whereas a small subset of OPCs are generated 
      from the dorsal neuroepithelial cells independent of the Shh pathway. Although 
      dorsally-derived OPCs (dOPCs) have been shown to participate in local axonal 
      myelination in the dorsolateral regions during development, it is not known 
      whether they are capable of migrating into the ventral region and myelinating 
      ventral axons. In this study, we confirmed and extended the previous study on the 
      developmental potential of dOPCs in the absence of ventrally-derived OPCs 
      (vOPCs). In Nestin-Smo conditional knockout (cKO) mice, when ventral 
      oligodendrogenesis was blocked, dOPCs were found to undergo rapid amplification, 
      spread to ventral spinal tissue, and eventually differentiated into myelinating 
      OLs in the ventral white matter with a temporal delay, providing genetic evidence 
      that dOPCs are capable of myelinating ventral axons in the mouse spinal cord.
FAU - Fang, Minxi
AU  - Fang M
AD  - Institute of Life Sciences, Zhejiang Key Laboratory of Organ Development and 
      Regeneration, College of Life and Environmental Sciences, Hangzhou Normal 
      University, Hangzhou, 310029, China.
FAU - Yu, Qian
AU  - Yu Q
AD  - Institute of Life Sciences, Zhejiang Key Laboratory of Organ Development and 
      Regeneration, College of Life and Environmental Sciences, Hangzhou Normal 
      University, Hangzhou, 310029, China.
AD  - CAS Center for Excellence in Brain Science and Intelligence Technology, Institute 
      of Neuroscience, Chinese Academy of Sciences, Shanghai, 200031, China.
FAU - Ou, Baiyan
AU  - Ou B
AD  - Institute of Life Sciences, Zhejiang Key Laboratory of Organ Development and 
      Regeneration, College of Life and Environmental Sciences, Hangzhou Normal 
      University, Hangzhou, 310029, China.
FAU - Huang, Hao
AU  - Huang H
AD  - Institute of Life Sciences, Zhejiang Key Laboratory of Organ Development and 
      Regeneration, College of Life and Environmental Sciences, Hangzhou Normal 
      University, Hangzhou, 310029, China.
FAU - Yi, Min
AU  - Yi M
AD  - Institute of Life Sciences, Zhejiang Key Laboratory of Organ Development and 
      Regeneration, College of Life and Environmental Sciences, Hangzhou Normal 
      University, Hangzhou, 310029, China.
FAU - Xie, Binghua
AU  - Xie B
AD  - Institute of Life Sciences, Zhejiang Key Laboratory of Organ Development and 
      Regeneration, College of Life and Environmental Sciences, Hangzhou Normal 
      University, Hangzhou, 310029, China.
FAU - Yang, Aifen
AU  - Yang A
AD  - Institute of Life Sciences, Zhejiang Key Laboratory of Organ Development and 
      Regeneration, College of Life and Environmental Sciences, Hangzhou Normal 
      University, Hangzhou, 310029, China.
FAU - Qiu, Mengsheng
AU  - Qiu M
AUID- ORCID: 0000-0001-6038-3718
AD  - Institute of Life Sciences, Zhejiang Key Laboratory of Organ Development and 
      Regeneration, College of Life and Environmental Sciences, Hangzhou Normal 
      University, Hangzhou, 310029, China. m0qiu001@yahoo.com.
FAU - Xu, Xiaofeng
AU  - Xu X
AUID- ORCID: 0000-0001-7910-0407
AD  - Institute of Life Sciences, Zhejiang Key Laboratory of Organ Development and 
      Regeneration, College of Life and Environmental Sciences, Hangzhou Normal 
      University, Hangzhou, 310029, China. xuxf1988@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20201013
PL  - Singapore
TA  - Neurosci Bull
JT  - Neuroscience bulletin
JID - 101256850
RN  - 0 (Hedgehog Proteins)
SB  - IM
MH  - Animals
MH  - Axons/*physiology
MH  - Cell Differentiation
MH  - Hedgehog Proteins
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - *Oligodendrocyte Precursor Cells/physiology
MH  - Spinal Cord/*cytology
MH  - White Matter/cytology
PMC - PMC7719134
OTO - NOTNLM
OT  - Dorsally-derived OPCs
OT  - Myelination
OT  - OPC proliferation
OT  - Oligodendrocyte differentiation
COIS- All authors claim that there are no conflicts of interest.
EDAT- 2020/10/15 06:00
MHDA- 2021/07/29 06:00
PMCR- 2021/12/01
CRDT- 2020/10/14 09:17
PHST- 2020/01/15 00:00 [received]
PHST- 2020/06/30 00:00 [accepted]
PHST- 2020/10/15 06:00 [pubmed]
PHST- 2021/07/29 06:00 [medline]
PHST- 2020/10/14 09:17 [entrez]
PHST- 2021/12/01 00:00 [pmc-release]
AID - 10.1007/s12264-020-00593-5 [pii]
AID - 593 [pii]
AID - 10.1007/s12264-020-00593-5 [doi]
PST - ppublish
SO  - Neurosci Bull. 2020 Dec;36(12):1474-1483. doi: 10.1007/s12264-020-00593-5. Epub 
      2020 Oct 13.