PMID- 33052493
OWN - NLM
STAT- MEDLINE
DCOM- 20220307
LR  - 20220307
IS  - 0942-0940 (Electronic)
IS  - 0001-6268 (Print)
IS  - 0001-6268 (Linking)
VI  - 164
IP  - 2
DP  - 2022 Feb
TI  - Primary versus recurrent surgery for glioblastoma-a prospective cohort study.
PG  - 429-438
LID - 10.1007/s00701-020-04605-1 [doi]
AB  - BACKGROUND: There is currently limited evidence for surgery in recurrent 
      glioblastoma (GBM). Our aim was to compare primary and recurrent surgeries, 
      regarding changes in perioperative, generic health-related quality of life 
      (HRQoL), complications, extents of resection and survival. METHODS: Between 2007 
      and 2018, 65 recurrent and 160 primary GBM resections were prospectively 
      enrolled. HRQoL was recorded with EQ-5D 3L preoperatively and at 1 month 
      postoperatively. Median perioperative change in HRQoL and change greater than the 
      minimal clinically important difference (MCID) were assessed. Tumour volume and 
      extent of resection were obtained from pre- and postoperative MRI scans. Survival 
      was assessed from date of surgery. RESULTS: Comparing recurrent surgeries and 
      primary resections, most variables were balanced at baseline, but median age (59 
      vs. 62, p = 0.005) and median preoperative tumour volume (14.9 vs. 25.3 ml, 
      p = 0.001) were lower in recurrent surgeries. There were no statistically 
      significant differences regarding complication rates, neurological deficits, 
      extents of resection or EQ-5D 3L index values at baseline and at follow-up. 
      Twenty (36.4%) recurrent resections vs. 39 (27.5%) primary resections reported 
      clinically significant deterioration in HRQoL at follow-up. Stratified by 
      clinically significant change in EQ-5D 3L, the survival distributions were not 
      statistically significantly different in either group. Survival was associated 
      with extent of resection (p = 0.015) in recurrent surgeries only. CONCLUSIONS: 
      Outcomes after primary and recurrent surgeries were quite similar in our 
      practice. As surgery may prolong life in patients where gross total resection is 
      obtainable with reasonable risk, the indication for surgery in GBM should perhaps 
      not differ that much in primary and recurrent resections.
CI  - (c) 2020. The Author(s).
FAU - Rubin, Maja Chava
AU  - Rubin MC
AUID- ORCID: 0000-0003-2330-0033
AD  - Department of Neuromedicine and Movement Science, Faculty of Medicine and Health 
      Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, 
      N-7491, Norway. maja.rubin@gmail.com.
FAU - Sagberg, Lisa Millgard
AU  - Sagberg LM
AD  - Department of Neuromedicine and Movement Science, Faculty of Medicine and Health 
      Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, 
      N-7491, Norway.
AD  - Department of Neurosurgery, St. Olav's University Hospital, Trondheim, Norway.
FAU - Jakola, Asgeir Store
AU  - Jakola AS
AD  - Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden.
AD  - Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg, 
      Sweden.
FAU - Solheim, Ole
AU  - Solheim O
AD  - Department of Neuromedicine and Movement Science, Faculty of Medicine and Health 
      Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, 
      N-7491, Norway.
AD  - Department of Neurosurgery, St. Olav's University Hospital, Trondheim, Norway.
LA  - eng
PT  - Journal Article
DEP - 20201014
PL  - Austria
TA  - Acta Neurochir (Wien)
JT  - Acta neurochirurgica
JID - 0151000
SB  - IM
MH  - *Glioblastoma/diagnostic imaging/surgery
MH  - Humans
MH  - Neoplasm Recurrence, Local/surgery
MH  - Postoperative Period
MH  - Prospective Studies
MH  - Quality of Life
MH  - Surveys and Questionnaires
PMC - PMC8854275
OTO - NOTNLM
OT  - Glioblastoma
OT  - Neurosurgery
OT  - Patient-reported outcome measures
OT  - Quality of life
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/10/15 06:00
MHDA- 2022/03/08 06:00
PMCR- 2020/10/14
CRDT- 2020/10/14 12:45
PHST- 2020/07/09 00:00 [received]
PHST- 2020/10/02 00:00 [accepted]
PHST- 2020/10/15 06:00 [pubmed]
PHST- 2022/03/08 06:00 [medline]
PHST- 2020/10/14 12:45 [entrez]
PHST- 2020/10/14 00:00 [pmc-release]
AID - 10.1007/s00701-020-04605-1 [pii]
AID - 4605 [pii]
AID - 10.1007/s00701-020-04605-1 [doi]
PST - ppublish
SO  - Acta Neurochir (Wien). 2022 Feb;164(2):429-438. doi: 10.1007/s00701-020-04605-1. 
      Epub 2020 Oct 14.