PMID- 33057771
OWN - NLM
STAT- MEDLINE
DCOM- 20210416
LR  - 20210731
IS  - 1432-0711 (Electronic)
IS  - 0932-0067 (Linking)
VI  - 303
IP  - 4
DP  - 2021 Apr
TI  - One elevated oral glucose tolerance test value in pregnancy increases the risk 
      for future diabetes mellitus type 2.
PG  - 933-941
LID - 10.1007/s00404-020-05827-5 [doi]
AB  - PURPOSE: Women with only one elevated 100 g OGTT value are not considered as 
      having gestational diabetes mellitus (GDM) and therefore there are no 
      recommendations to address this population as a risk group for type 2 diabetes 
      mellitus (T2DM). We aimed to elucidate whether one elevated OGTT value increases 
      the risk for T2DM. METHODS: A retrospective population-based cohort study of 
      women with a first diagnosis of GDM who delivered between 1991 and 2011 was 
      conducted. Women were divided according to GDM diagnosis criteria into three 
      groups: (1) at least two elevated values of Carpenter and Coustan criteria (C&C; 
      N = 209), (2) At least two elevated values of the National Diabetes Data Group 
      (NDDG) criteria (NDDG2; N = 290) and (3) only one elevated value of the NDDG 
      criteria (NDDG1; N = 226). A fourth group comprising women without GDM was 
      included (control; N = 352). The primary outcome was the development of T2DM. 
      RESULTS: The mean follow-up was 12.4 +/- 5.3 years and the mean age at follow-up 
      was 43.0 +/- 5.7 years. The rate of T2DM in the control, C&C, NDDG1 and NDDG2 
      groups were 5%, 18%, 19% and 31%, respectively. All GDM diagnoses were 
      independent risk factors for T2DM in multivariable Cox regression when compared 
      to controls, adjusted hazard ratio and 95% CI: C&C 7.8 [95% CI 3.7-16.4], NDDG1 
      5.5 [2.6-11.6], and NDDG2 10.5 [5.2-21.4]. Additional independent risk factors 
      were parity, fasting and 1-h post-glucose load of the OGTT and insulin use. 
      CONCLUSIONS: Women with one elevated OGTT value using the NDDG criteria are at 
      increased risk for T2DM. Further studies are needed to decide whether those women 
      should be considered a focus group for long-term surveillance and T2DM prevention 
      interventions.
FAU - Yefet, Enav
AU  - Yefet E
AUID- ORCID: 0000-0002-3102-0739
AD  - Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel. 
      enavy1@gmail.com.
AD  - Department of Obstetrics and Gynecology, Baruch Padeh Medical Center Poriya, 
      Tiberias, Israel. enavy1@gmail.com.
AD  - Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel. 
      enavy1@gmail.com.
FAU - Schwartz, Naama
AU  - Schwartz N
AD  - Research Authority, Emek Medical Center, Afula, Israel.
FAU - Sliman, Basma
AU  - Sliman B
AD  - Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel.
FAU - Nachum, Zohar
AU  - Nachum Z
AD  - Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel.
AD  - Rappaport Faculty of Medicine, Technion, Haifa, Israel.
LA  - eng
PT  - Journal Article
DEP - 20201014
PL  - Germany
TA  - Arch Gynecol Obstet
JT  - Archives of gynecology and obstetrics
JID - 8710213
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology/etiology
MH  - Diabetes, Gestational/*diagnosis
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Israel/epidemiology
MH  - Pregnancy
MH  - *Prenatal Diagnosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Gestational diabetes mellitus
OT  - Oral glucose tolerance test
OT  - Pregnancy
OT  - Type 2 diabetes mellitus
EDAT- 2020/10/16 06:00
MHDA- 2021/04/17 06:00
CRDT- 2020/10/15 17:37
PHST- 2020/08/18 00:00 [received]
PHST- 2020/09/26 00:00 [accepted]
PHST- 2020/10/16 06:00 [pubmed]
PHST- 2021/04/17 06:00 [medline]
PHST- 2020/10/15 17:37 [entrez]
AID - 10.1007/s00404-020-05827-5 [pii]
AID - 10.1007/s00404-020-05827-5 [doi]
PST - ppublish
SO  - Arch Gynecol Obstet. 2021 Apr;303(4):933-941. doi: 10.1007/s00404-020-05827-5. 
      Epub 2020 Oct 14.