PMID- 33058842
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20220531
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 511
DP  - 2020 Dec
TI  - Circulating nicotinamide adenine dinucleotide-ubiquinone oxidoreductase chain 6 
      is associated with disease activity of anti-neutrophil cytoplasmic 
      antibody-associated vasculitis.
PG  - 125-131
LID - S0009-8981(20)30491-5 [pii]
LID - 10.1016/j.cca.2020.10.009 [doi]
AB  - BACKGROUND: Increased serum and urinary mitochondrial DNA have been demonstrated 
      in antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Here we 
      investigated the significance of serum nicotinamide adenine 
      dinucleotide-ubiquinone oxidoreductase chain 6 (ND6), which is encoded by mtDNA 
      and can attract neutrophils, in AAV. METHODS: Thirty-seven AAV patients (32 
      patients with positive myeloperoxidase-ANCA and 5 patients with proteinase 
      3-ANCA) were enrolled. Relationship between serum ND6 and clinico-laboratory 
      characteristics were analyzed. RESULTS: The ND6 level of patients was higher than 
      normal people (46.56 +/- 23.67 pg/mL vs. 4.95 +/- 2.45 pg/mL, P < 0.001) The ND6 
      levels of patients who needed hemodialysis at disease onset and who had pulmonary 
      hemorrhage (PH) were higher than that of the corresponding controls (P = 0.004 
      and 0.044 respectively). The ND6 level negatively correlated with the percentages 
      of normal glomeruli in kidney biopsy. The AUC of ROC curve to diagnose 
      hemodialysis and PH was 0.804 and 0.750 respectively. ND6 level positively 
      correlated with Birmingham Vasculitis Activity Score in active disease, and 
      returned to normal after remission. Patients with higher serum ND6 had higher 
      mortality (P = 0.023). CONCLUSIONS: Serum ND6 increases in active AAV, and its 
      level correlates with the severity of disease. High ND6 level is associated with 
      severe organ injury and predicts poor prognosis of AAV.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Tian, Shun-Li
AU  - Tian SL
AD  - Department of Geratology, Tianjin Geriatric Institute, Tianjin Medical University 
      General Hospital, Tianjin 300052, China. Electronic address: tianshunli@tom.com.
FAU - Bai, Xue
AU  - Bai X
AD  - Department of Nephrology, Tianjin Medical University General Hospital, Tianjin 
      300052, China. Electronic address: bxue0521@163.com.
FAU - Xu, Peng-Cheng
AU  - Xu PC
AD  - Department of Nephrology, Tianjin Medical University General Hospital, Tianjin 
      300052, China. Electronic address: nkxpc@163.com.
FAU - Chen, Tong
AU  - Chen T
AD  - Department of Hematology, Tianjin Medical University General Hospital, Tianjin 
      300052, China. Electronic address: chentong2014601004@163.com.
FAU - Gao, Shan
AU  - Gao S
AD  - Department of Nephrology, Tianjin Medical University General Hospital, Tianjin 
      300052, China. Electronic address: leeshan1225@sina.com.
FAU - Hu, Shui-Yi
AU  - Hu SY
AD  - Department of Nephrology, Tianjin Medical University General Hospital, Tianjin 
      300052, China. Electronic address: hushuiyi33@163.com.
FAU - Wei, Li
AU  - Wei L
AD  - Department of Nephrology, Tianjin Medical University General Hospital, Tianjin 
      300052, China. Electronic address: weilee1981@163.com.
FAU - Jia, Jun-Ya
AU  - Jia JY
AD  - Department of Nephrology, Tianjin Medical University General Hospital, Tianjin 
      300052, China. Electronic address: jiajunya@126.com.
FAU - Yan, Tie-Kun
AU  - Yan TK
AD  - Department of Nephrology, Tianjin Medical University General Hospital, Tianjin 
      300052, China. Electronic address: tiekunyan@163.com.
LA  - eng
PT  - Journal Article
DEP - 20201012
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0U46U6E8UK (NAD)
RN  - 1339-63-5 (Ubiquinone)
RN  - EC 1.- (Oxidoreductases)
SB  - IM
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - Humans
MH  - *NAD
MH  - Oxidoreductases
MH  - Ubiquinone
OTO - NOTNLM
OT  - ANCA
OT  - Formyl peptide
OT  - Mitochondria
OT  - ND6
OT  - Vasculitis
EDAT- 2020/10/16 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/10/15 20:09
PHST- 2020/04/03 00:00 [received]
PHST- 2020/10/07 00:00 [revised]
PHST- 2020/10/07 00:00 [accepted]
PHST- 2020/10/16 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/10/15 20:09 [entrez]
AID - S0009-8981(20)30491-5 [pii]
AID - 10.1016/j.cca.2020.10.009 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2020 Dec;511:125-131. doi: 10.1016/j.cca.2020.10.009. Epub 2020 
      Oct 12.