PMID- 33058844
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 511
DP  - 2020 Dec
TI  - LDL-C/HDL-C ratio associated with carotid intima-media thickness and carotid 
      plaques in male but not female patients with type 2 diabetes.
PG  - 215-220
LID - S0009-8981(20)30496-4 [pii]
LID - 10.1016/j.cca.2020.10.014 [doi]
AB  - BACKGROUND: We investigated the associations between low-density lipoprotein 
      cholesterol (LDL-C) to high-density cholesterol (HDL-C) ratio (LDL-C/HDL-C) with 
      structural and functional early atherosclerosis vascular changes in patients with 
      type 2 diabetes mellitus (T2DM). METHODS: This hospital-based cross-sectional 
      study included 814 patients with T2DM. Structural atherosclerotic parameters 
      included carotid intima-media thickness (CIMT) and carotid plaque, the 
      cardio-ankle vascular index (CAVI) was considered as the functional parameter. 
      Multiple linear regression and logistic regression models were preformed to 
      identify the associations between LDL-C/HDL-C with atherosclerotic parameters. 
      RESULTS: Increased LDL-C/HDL-C corresponded with the increase levels in CIMT and 
      percentage of carotid plaque. LDL-C/HDL-C was found to be positively associated 
      with CIMT both in female and male patients in unadjusted model. This association 
      persisted in male patients but not in female patients after adjusted for other 
      related factors. No association was found between LDL-C/HDL-C with CAVI both in 
      female and male patients. LDL-C/HDL-C was positively associated with the presence 
      of carotid plaque in male patients. However, this association was not found in 
      female patients. CONCLUSION: LDL-C/HDL-C was positively associated with CIMT and 
      presence of carotid plaque though not with CAVI in male T2DM patients. However, 
      these associations were not observed in female patients.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Du, Rong
AU  - Du R
AD  - Department of Endocrinology and Metabolism, Hospital of Chengdu Office of 
      People's Government of Tibetan Autonomous Region, Chengdu, China.
FAU - Li, Mingxia
AU  - Li M
AD  - Department of Endocrinology and Metabolism, Hospital of Chengdu Office of 
      People's Government of Tibetan Autonomous Region, Chengdu, China.
FAU - Wang, Xi
AU  - Wang X
AD  - Department of Endocrinology and Metabolism, Hospital of Chengdu Office of 
      People's Government of Tibetan Autonomous Region, Chengdu, China.
FAU - Wang, Suyuan
AU  - Wang S
AD  - Department of Endocrinology and Metabolism, Hospital of Chengdu Office of 
      People's Government of Tibetan Autonomous Region, Chengdu, China.
FAU - Li, Sheyu
AU  - Li S
AD  - Departments of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu, China.
FAU - Tian, Haoming
AU  - Tian H
AD  - Departments of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu, China.
FAU - Wu, Yunhong
AU  - Wu Y
AD  - Department of Endocrinology and Metabolism, Hospital of Chengdu Office of 
      People's Government of Tibetan Autonomous Region, Chengdu, China.
FAU - Zhang, Chenghui
AU  - Zhang C
AD  - Department of Endocrinology and Metabolism, Hospital of Chengdu Office of 
      People's Government of Tibetan Autonomous Region, Chengdu, China. Electronic 
      address: zchscu0616@163.com.
LA  - eng
PT  - Journal Article
DEP - 20201013
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
SB  - IM
MH  - *Carotid Intima-Media Thickness
MH  - Cholesterol, HDL
MH  - Cholesterol, LDL
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Risk Factors
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Cardio-ankle vascular index
OT  - Carotid intima-media thickness
OT  - Carotid plaque
OT  - Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio
OT  - Type 2 diabetes mellitus
EDAT- 2020/10/16 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/10/15 20:09
PHST- 2020/08/04 00:00 [received]
PHST- 2020/10/04 00:00 [revised]
PHST- 2020/10/09 00:00 [accepted]
PHST- 2020/10/16 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/10/15 20:09 [entrez]
AID - S0009-8981(20)30496-4 [pii]
AID - 10.1016/j.cca.2020.10.014 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2020 Dec;511:215-220. doi: 10.1016/j.cca.2020.10.014. Epub 2020 
      Oct 13.