PMID- 3305938
OWN - NLM
STAT- MEDLINE
DCOM- 19871005
LR  - 20220408
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 14 Spec No
DP  - 1987 May
TI  - Matrix metalloproteinases 1, 2, and 3 from rheumatoid synovial cells are 
      sufficient to destroy joints.
PG  - 41-2
AB  - A neutral metalloproteinase has been isolated and purified from adherent 
      rheumatoid synovial cells in culture. This protease, named matrix 
      metalloproteinase 3, (MMP-3) degrades gelatin, proteoglycan, fibronectin, type IV 
      collagen, laminin, and the N propeptide of type I procollagen. It can be 
      separated from MMP-2 (a potent gelatinase), and MMP-1, an interstitial 
      collagenase. MMP-3 is released from cells as a proenzyme of 55 Kda. Activation by 
      trypsin or organic mercurials produces 2 active species of 45 Kda and 28 Kda. The 
      enzyme contains zinc as an intrinsic component and requires calcium for 
      conformational stability. In concert, active MMP-1, -2, and -3 can destroy all 
      significant structural proteins of joint structures.
FAU - Okada, Y
AU  - Okada Y
FAU - Nagase, H
AU  - Nagase H
FAU - Harris, E D Jr
AU  - Harris ED Jr
LA  - eng
GR  - AM 33714/AM/NIADDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - EC 3.4.- (Endopeptidases)
RN  - EC 3.4.24.- (Metalloendopeptidases)
SB  - IM
MH  - Arthritis, Rheumatoid/*enzymology/etiology
MH  - Endopeptidases/*metabolism
MH  - Extracellular Matrix/enzymology
MH  - Humans
MH  - Metalloendopeptidases
MH  - Synovial Membrane/*enzymology
EDAT- 1987/05/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1987/05/01 00:00
PHST- 1987/05/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1987/05/01 00:00 [entrez]
PST - ppublish
SO  - J Rheumatol. 1987 May;14 Spec No:41-2.