PMID- 33060003
OWN - NLM
STAT- MEDLINE
DCOM- 20210203
LR  - 20210203
IS  - 1873-7072 (Electronic)
IS  - 0308-8146 (Linking)
VI  - 342
DP  - 2021 Apr 16
TI  - Probing gold nanoparticles for the desensitization to beta-lactoglobulin from 
      binding mechanism, structure and IgE binding changes.
PG  - 128329
LID - S0308-8146(20)32191-9 [pii]
LID - 10.1016/j.foodchem.2020.128329 [doi]
AB  - Because of the adsorption of proteins, gold nanoparticles (AuNPs) create 
      potential biological risks in biomedicine, leading to the formation of the 
      protein corona. This adsorption is mainly due to the formation of gold-sulfur 
      (AuS) covalent bonds between the AuNPs and the -SH groups, causing bioactivity 
      denaturation and biological problems; however, it could also lead to some 
      biological benefits. We explored AuNPs as a potential material for 
      desensitization to allergens, such as beta-lactoglobulin (betaLG). To address the 
      desensitization of AuNPs, we investigated the binding mechanism and the specific 
      relationship of the time evolution of AuS bond, secondary structure, and allergy 
      changes. The formation of AuS bond takes approximately 9 h, consistent with the 
      complete changes time in secondary structure and immunoglobulin E (IgE) combining 
      capacity of the betaLG, decreasing allergic reactions. These results indicate that 
      AuNPs have the potential to minimize allergic reactions in the future.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Zhang, Xiaoning
AU  - Zhang X
AD  - School of Food Science & Engineering, Qilu University of Technology, 250353 
      Jinan, China. Electronic address: xiaoningzhang@126.com.
FAU - Li, Meifeng
AU  - Li M
AD  - School of Public Health, Chengdu University of Traditional Chinese Medicine, 
      610075 Chengdu, China.
FAU - Lv, Yuanping
AU  - Lv Y
AD  - College of Biomass Sciences and Engineering, Sichuan University, 610065 Chengdu, 
      China.
FAU - Sun, Xiaoling
AU  - Sun X
AD  - School of Food Science & Engineering, Qilu University of Technology, 250353 
      Jinan, China.
FAU - Han, Yao
AU  - Han Y
AD  - School of Food Science & Engineering, Qilu University of Technology, 250353 
      Jinan, China.
FAU - Liu, Bing
AU  - Liu B
AD  - Resources and Environment Innovation Research Institute, School of Municipal and 
      Environmental Engineering, Shandong Jianzhu University, Jinan 250101, Shandong, 
      China.
FAU - Zhao, Xiangzhong
AU  - Zhao X
AD  - School of Food Science & Engineering, Qilu University of Technology, 250353 
      Jinan, China. Electronic address: xiangzhongzhao@126.com.
FAU - Huang, Xiaowen
AU  - Huang X
AD  - State Key Laboratory of Biobased Materials and Green Papermaking, School of 
      Bioengineering, Qilu University of Technology, 250353 Jinan, China. Electronic 
      address: huangxiaowen2013@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20201008
PL  - England
TA  - Food Chem
JT  - Food chemistry
JID - 7702639
RN  - 0 (Allergens)
RN  - 0 (Lactoglobulins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 7440-57-5 (Gold)
SB  - IM
MH  - Adsorption
MH  - Allergens/chemistry/metabolism
MH  - Gold/*chemistry
MH  - Immunoglobulin E/*metabolism
MH  - Lactoglobulins/*chemistry/*metabolism
MH  - Metal Nanoparticles/*chemistry
MH  - Protein Structure, Secondary
OTO - NOTNLM
OT  - AuS bonds
OT  - Desensitization
OT  - Gold nanoparticles (AuNPs)
OT  - Protein corona
OT  - beta-Lactoglobulin (betaLG)
EDAT- 2020/10/17 06:00
MHDA- 2021/02/04 06:00
CRDT- 2020/10/16 05:38
PHST- 2020/04/12 00:00 [received]
PHST- 2020/09/17 00:00 [revised]
PHST- 2020/10/05 00:00 [accepted]
PHST- 2020/10/17 06:00 [pubmed]
PHST- 2021/02/04 06:00 [medline]
PHST- 2020/10/16 05:38 [entrez]
AID - S0308-8146(20)32191-9 [pii]
AID - 10.1016/j.foodchem.2020.128329 [doi]
PST - ppublish
SO  - Food Chem. 2021 Apr 16;342:128329. doi: 10.1016/j.foodchem.2020.128329. Epub 2020 
      Oct 8.