PMID- 33062570
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201020
IS  - 2188-4226 (Print)
IS  - 2188-4226 (Electronic)
IS  - 2188-4226 (Linking)
VI  - 7
IP  - 4
DP  - 2020 Sep
TI  - Well-differentiated Astroblastoma with Both Focal Anaplastic Features and a 
      Meningioma 1 Gene Alteration.
PG  - 205-210
LID - 10.2176/nmccrj.cr.2020-0028 [doi]
AB  - A 6-year-old female was incidentally found to have a brain tumor. Magnetic 
      resonance imaging (MRI) demonstrated a gadolinium-enhanced mass in the left 
      parietal lobe. We performed gross total resection with the assistance of 
      fluorescent guidance by 5-aminolevulinic acid (5-ALA). A histological examination 
      of the tumor specimen showed well-differentiated astroblastic features with focal 
      anaplasia. Fluorescence in situ hybridization (FISH) revealed meningioma 1 (MN1) 
      gene alteration and supported our diagnosis. She received local radiotherapy and 
      oral temozolomide followed by maintenance temozolomide chemotherapy, and the 
      tumor was well controlled without any neurological deficit for 27 months. Our 
      case is considered to be valuable since it describes a patient who is diagnosed 
      to have a well-differentiated astroblastoma with both focal anaplastic features 
      and MN1 gene rearrangement. A larger study is warranted to establish evidence 
      supporting the diagnosis and treatment of astroblastoma with molecular 
      characteristic features. MN1 alteration will be a diagnostic marker for 
      astroblastoma in the future.
CI  - (c) 2020 The Japan Neurosurgical Society.
FAU - Fudaba, Hirotaka
AU  - Fudaba H
AD  - Department of Neurosurgery, Oita University Faculty of Medicine, Yufu, Oita, 
      Japan.
FAU - Momii, Yasutomo
AU  - Momii Y
AD  - Department of Neurosurgery, Oita University Faculty of Medicine, Yufu, Oita, 
      Japan.
FAU - Kawasaki, Yukari
AU  - Kawasaki Y
AD  - Department of Neurosurgery, Oita University Faculty of Medicine, Yufu, Oita, 
      Japan.
FAU - Goto, Hironori
AU  - Goto H
AD  - Department of Pediatrics, Oita University Faculty of Medicine, Yufu, Oita, Japan.
FAU - Nobusawa, Sumihito
AU  - Nobusawa S
AD  - Department of Human Pathology, Gunma University Graduate School of Medicine, 
      Maebashi, Gunma, Japan.
FAU - Fujiki, Minoru
AU  - Fujiki M
AD  - Department of Neurosurgery, Oita University Faculty of Medicine, Yufu, Oita, 
      Japan.
LA  - eng
PT  - Case Reports
DEP - 20200916
PL  - Japan
TA  - NMC Case Rep J
JT  - NMC case report journal
JID - 101692589
PMC - PMC7538458
OTO - NOTNLM
OT  - Meningioma 1 gene
OT  - anaplastic
OT  - astroblastoma
OT  - brain neoplasms
OT  - child
COIS- Conflicts of Interest Disclosure The authors declare there are no conflicts of 
      interest.
EDAT- 2020/10/17 06:00
MHDA- 2020/10/17 06:01
PMCR- 2020/09/16
CRDT- 2020/10/16 05:55
PHST- 2020/02/15 00:00 [received]
PHST- 2020/03/18 00:00 [accepted]
PHST- 2020/10/16 05:55 [entrez]
PHST- 2020/10/17 06:00 [pubmed]
PHST- 2020/10/17 06:01 [medline]
PHST- 2020/09/16 00:00 [pmc-release]
AID - nmccrj-7-205 [pii]
AID - 10.2176/nmccrj.cr.2020-0028 [doi]
PST - epublish
SO  - NMC Case Rep J. 2020 Sep 16;7(4):205-210. doi: 10.2176/nmccrj.cr.2020-0028. 
      eCollection 2020 Sep.