PMID- 33062929
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220417
IS  - 2515-8414 (Electronic)
IS  - 2515-8414 (Linking)
VI  - 12
DP  - 2020 Jan-Dec
TI  - Serum malondialdehyde, monocyte chemoattractant protein-1, and vitamin C levels 
      in wet type age-related macular degeneration patients.
PG  - 2515841420951682
LID - 10.1177/2515841420951682 [doi]
LID - 2515841420951682
AB  - PURPOSE: The purpose of this study was to investigate the serum levels of 
      malondialdehyde (MDA) which is a marker of oxidative stress, monocyte 
      chemoattractant protein-1 (MCP-1) which has an important role in inflammation, 
      and vitamin C which has antioxidant properties in patients with wet age-related 
      macular degeneration (wAMD). METHODS: Thirty patients with wAMD were included in 
      the study and serum levels of MDA, MCP-1, and vitamin C were compared with 
      healthy participants (n = 30). Serum vitamin C and MDA levels were measured using 
      a spectrophotometric method. Serum MCP-1 levels were determined by the ELISA 
      method. RESULTS: MCP-1 and MDA levels were higher in patients with wAMD compared 
      with the control group (p < 0.05). Serum vitamin C levels were lower in patients 
      with wAMD compared with the control group (p < 0.05). CONCLUSIONS: The increase 
      in the MCP-1 levels in patients with wAMD may be associated with increased 
      inflammation in wAMD. Decreased serum vitamin C and elevated MDA levels in 
      patients with wAMD suggest increased oxidative stress in wAMD patients. These 
      results indicate that the increased oxidative stress and inflammation can play a 
      role in the pathogenesis of wAMD.
CI  - (c) The Author(s), 2020.
FAU - Zor, Ramazan Kursad
AU  - Zor RK
AUID- ORCID: 0000-0002-3233-7906
AD  - Department of Ophthalmology, School of Medicine, Nigde Omer Halisdemir 
      University, Bor Yolu, Nigde 51100, Turkey.
FAU - Ersan, Serpil
AU  - Ersan S
AD  - Department of Biochemistry, School of Medicine, Nigde Omer Halisdemir University, 
      Nigde, Turkey.
FAU - Kucuk, Erkut
AU  - Kucuk E
AUID- ORCID: 0000-0002-1474-9237
AD  - Department of Ophthalmology, School of Medicine, Nigde Omer Halisdemir 
      University, Nigde, Turkey.
FAU - Yildirim, Gamze
AU  - Yildirim G
AUID- ORCID: 0000-0003-3058-6308
AD  - Department of Ophthalmology, Nigde Omer Halisdemir Education and Research 
      Hospital, Nigde, Turkey.
FAU - Sari, Ismail
AU  - Sari I
AD  - Department of Biochemistry, School of Medicine, Nigde Omer Halisdemir University, 
      Nigde, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20200930
PL  - United States
TA  - Ther Adv Ophthalmol
JT  - Therapeutic advances in ophthalmology
JID - 101728805
PMC - PMC7536475
OTO - NOTNLM
OT  - age-related macular degeneration
OT  - choroidal neovascularization
OT  - inflammation
OT  - malondialdehyde
OT  - monocyte chemoattractant protein-1
OT  - oxidative stress
COIS- Conflict of interest statement: The authors declared no potential conflicts of 
      interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2020/10/17 06:00
MHDA- 2020/10/17 06:01
PMCR- 2020/09/30
CRDT- 2020/10/16 05:57
PHST- 2019/12/29 00:00 [received]
PHST- 2020/07/13 00:00 [accepted]
PHST- 2020/10/16 05:57 [entrez]
PHST- 2020/10/17 06:00 [pubmed]
PHST- 2020/10/17 06:01 [medline]
PHST- 2020/09/30 00:00 [pmc-release]
AID - 10.1177_2515841420951682 [pii]
AID - 10.1177/2515841420951682 [doi]
PST - epublish
SO  - Ther Adv Ophthalmol. 2020 Sep 30;12:2515841420951682. doi: 
      10.1177/2515841420951682. eCollection 2020 Jan-Dec.