PMID- 33063535
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 1479-9731 (Electronic)
IS  - 1479-9723 (Print)
IS  - 1479-9723 (Linking)
VI  - 17
DP  - 2020 Jan-Dec
TI  - Diffuse panbronchiolitis: A case report from a Chinese consanguineous marriage 
      family and literature review.
PG  - 1479973120961847
LID - 10.1177/1479973120961847 [doi]
LID - 1479973120961847
AB  - Diffuse panbronchiolitis (DPB) is a chronic diffuse airway inflammatory disease, 
      which is strongly associated with the class I human leukocyte antigen (HLA) 
      alleles. Here, we report a pair of sisters who have been suffering from chronic 
      cough, expectoration and wheezing for many years. They were previously 
      misdiagnosed as chronic bronchitis and bronchial asthma, and were recently 
      diagnosed as diffuse panbronchiolitis. The 36-year-old elder sister suffered from 
      diffuse panbronchiolitis complicated with pulmonary tuberculosis. The 30-year-old 
      younger sister suffered from diffuse panbronchiolitis complicated with bronchial 
      asthma and bronchiectasis. We have performed HLA genotyping research on the two 
      sisters, their parents and younger brother. The results showed that all family 
      members were positive for HLA-A24 and HLA-B13. The younger sister and mother were 
      positive for HLA-A2. The younger brother and father were positive for HLA-A11. We 
      suspect that the two sisters' disease susceptibility may be caused by their 
      parents' consanguineous marriage. In this study, we reported the clinical 
      characteristics of the two sisters with diffuse panbronchiolitis and shared the 
      associated HLA genotyping results of this family cluster, hoping to provide 
      reference for the etiology, diagnosis and treatment of this disease.
FAU - He, Fang
AU  - He F
AD  - Department of Respiratory and Critical Care Medicine, 117913Affiliated Hospital 
      of North Sichuan Medical College, Nanchong, China.
AD  - 74655North Sichuan Medical College, Nanchong, China.
FAU - Gong, Hai-Ying
AU  - Gong HY
AD  - Department of Respiratory and Critical Care Medicine, 117913Affiliated Hospital 
      of North Sichuan Medical College, Nanchong, China.
AD  - 74655North Sichuan Medical College, Nanchong, China.
FAU - Jiang, Guo-Lu
AU  - Jiang GL
AD  - Department of Respiratory and Critical Care Medicine, 117913Affiliated Hospital 
      of North Sichuan Medical College, Nanchong, China.
FAU - Chen, Xiao-Ju
AU  - Chen XJ
AD  - Department of Respiratory and Critical Care Medicine, 117913Affiliated Hospital 
      of North Sichuan Medical College, Nanchong, China.
FAU - Yao, Qian-Jing
AU  - Yao QJ
AD  - 74655North Sichuan Medical College, Nanchong, China.
FAU - Jiang, Li
AU  - Jiang L
AUID- ORCID: 0000-0003-0891-8775
AD  - Department of Respiratory and Critical Care Medicine, 117913Affiliated Hospital 
      of North Sichuan Medical College, Nanchong, China.
AD  - 74655North Sichuan Medical College, Nanchong, China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - England
TA  - Chron Respir Dis
JT  - Chronic respiratory disease
JID - 101197408
RN  - Diffuse panbronchiolitis
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Bronchiolitis/diagnosis/genetics
MH  - China
MH  - Consanguinity
MH  - *Genetic Predisposition to Disease
MH  - Haemophilus Infections
MH  - Humans
MH  - Male
PMC - PMC7573727
OTO - NOTNLM
OT  - DPB
OT  - Diffuse panbronchiolitis
OT  - HLA genotyping
OT  - clinical characteristics
OT  - consanguineous marriage
COIS- Declaration of conflicting interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2020/10/17 06:00
MHDA- 2021/10/26 06:00
PMCR- 2020/10/16
CRDT- 2020/10/16 08:37
PHST- 2020/10/16 08:37 [entrez]
PHST- 2020/10/17 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2020/10/16 00:00 [pmc-release]
AID - 10.1177_1479973120961847 [pii]
AID - 10.1177/1479973120961847 [doi]
PST - ppublish
SO  - Chron Respir Dis. 2020 Jan-Dec;17:1479973120961847. doi: 
      10.1177/1479973120961847.