PMID- 33064198
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20210818
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 259
IP  - 4
DP  - 2021 Apr
TI  - Influence of vitrectomy on the progression of dry age-related macular 
      degeneration.
PG  - 847-853
LID - 10.1007/s00417-020-04943-x [doi]
AB  - PURPOSE: To demonstrate whether pars plana vitrectomy (PPV) changes the 
      progression of dry age-related macular degeneration (AMD) by assessing 
      longitudinal changes in drusen volume over follow-up. METHODS: Dry AMD patients 
      who had undergone unilateral PPV for symptomatic vitreomacular disorders were 
      evaluated for the progression of disease by spectral domain-optical coherence 
      tomography (SD-OCT) features including drusen volume, development of geographic 
      atrophy, or choroidal neovascularization during follow-up. Drusen volume was 
      manually calculated using an image processing software (ImageJ, NIH) on raster 
      SD-OCT scans. Mean change in drusen volume of surgery eyes was compared with 
      values of the fellow eyes of the same subjects (control group). RESULTS: Among 
      183 eyes with both vitreoretinal disorder and dry AMD, 48 eyes of 24 patients met 
      the inclusion criteria and were included. The mean drusen volume change during a 
      mean of 25.49 +/- 23.35 months of follow-up (range: 6.00-86.87 months) was 
      4.236.899 +/- 20.488.913 mum(3) in the study eye and 7.796.357 +/- 34.798.519 mum(3) in 
      the fellow eye (p = 0.297). Best-corrected visual acuity (BCVA) significantly 
      increased from 0.40 +/- 0.18 logMAR ( approximately  20/50 Snellen equivalent) to 0.32 +/- 0.31 ( approximately  
      20/41 Snellen equivalent) after surgery (p = 0.012) in the study group while BCVA 
      remained stable in the control group (0.19 +/- 0.34 logMAR [ approximately  20/30 Snellen 
      equivalent] at baseline and 0.20 +/- 0.31 logMAR [ approximately  20/31 Snellen equivalent], p = 
      0.432). Choroidal neovascularization developed in 1 vitrectomized eye (4.54%) and 
      in 1 eye (4.54%) from the control group during follow-up. CONCLUSION: Vitrectomy 
      did not seem to worsen dry AMD progression; even more visual acuity may improve 
      despite a slight increase in drusen volume following surgery.
FAU - Muftuoglu, Ilkay Kilic
AU  - Muftuoglu IK
AD  - Department of Ophthalmology, Jacobs Retina Center, Shiley Eye Institute, 
      University of California San Diego, 9415 Campus Point Drive, La Jolla, CA, 92037, 
      USA.
AD  - Department of Ophthalmology, Istanbul Training and Research Hospital, Istanbul, 
      Turkey.
FAU - Lin, Tiezhu
AU  - Lin T
AD  - Department of Ophthalmology, Jacobs Retina Center, Shiley Eye Institute, 
      University of California San Diego, 9415 Campus Point Drive, La Jolla, CA, 92037, 
      USA.
AD  - He Eye Specialists Hospital, He University, Shenyang, Liaoning Province, China.
FAU - Bartsch, Dirk-Uwe
AU  - Bartsch DU
AD  - Department of Ophthalmology, Jacobs Retina Center, Shiley Eye Institute, 
      University of California San Diego, 9415 Campus Point Drive, La Jolla, CA, 92037, 
      USA.
FAU - Freeman, William R
AU  - Freeman WR
AD  - Department of Ophthalmology, Jacobs Retina Center, Shiley Eye Institute, 
      University of California San Diego, 9415 Campus Point Drive, La Jolla, CA, 92037, 
      USA. wrfreeman@ucsd.edu.
LA  - eng
GR  - R01 EY016323-09A1/NH/NIH HHS/United States
GR  - P30 EY022589/EY/NEI NIH HHS/United States
GR  - R01 EY016323-09A1/NH/NIH HHS/United States
GR  - P30 EY022589/EY/NEI NIH HHS/United States
PT  - Journal Article
DEP - 20201016
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - *Choroidal Neovascularization/diagnosis/surgery
MH  - *Geographic Atrophy/diagnosis
MH  - Humans
MH  - *Macular Degeneration
MH  - *Retinal Drusen/diagnosis/etiology
MH  - Tomography, Optical Coherence
MH  - Vitrectomy
OTO - NOTNLM
OT  - AMD
OT  - AMD progression
OT  - Drusen volume
OT  - Dry AMD
OT  - OCT
OT  - PPV
OT  - Pars plana vitrectomy
EDAT- 2020/10/17 06:00
MHDA- 2021/08/19 06:00
CRDT- 2020/10/16 12:09
PHST- 2020/07/16 00:00 [received]
PHST- 2020/09/17 00:00 [accepted]
PHST- 2020/09/09 00:00 [revised]
PHST- 2020/10/17 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2020/10/16 12:09 [entrez]
AID - 10.1007/s00417-020-04943-x [pii]
AID - 10.1007/s00417-020-04943-x [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2021 Apr;259(4):847-853. doi: 
      10.1007/s00417-020-04943-x. Epub 2020 Oct 16.