PMID- 33066304
OWN - NLM
STAT- MEDLINE
DCOM- 20210225
LR  - 20210225
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 20
DP  - 2020 Oct 13
TI  - Roadmap for Stroke: Challenging the Role of the Neuronal Extracellular Matrix.
LID - 10.3390/ijms21207554 [doi]
LID - 7554
AB  - Stroke is a major challenge in modern medicine and understanding the role of the 
      neuronal extracellular matrix (NECM) in its pathophysiology is fundamental for 
      promoting brain repair. Currently, stroke research is focused on the 
      neurovascular unit (NVU). Impairment of the NVU leads to neuronal loss through 
      post-ischemic and reperfusion injuries, as well as coagulatory and inflammatory 
      processes. The ictal core is produced in a few minutes by the high metabolic 
      demand of the central nervous system. Uncontrolled or prolonged inflammatory 
      response is characterized by leukocyte infiltration of the injured site that is 
      limited by astroglial reaction. The metabolic failure reshapes the NECM through 
      matrix metalloproteinases (MMPs) and novel deposition of structural proteins 
      continues within months of the acute event. These maladaptive reparative 
      processes are responsible for the neurological clinical phenotype. In this 
      review, we aim to provide a systems biology approach to stroke pathophysiology, 
      relating the injury to the NVU with the pervasive metabolic failure, inflammatory 
      response and modifications of the NECM. The available data will be used to build 
      a protein-protein interaction (PPI) map starting with 38 proteins involved in 
      stroke pathophysiology, taking into account the timeline of damage and the 
      co-expression scores of their RNA patterns The application of the proposed 
      network could lead to a more accurate design of translational experiments aiming 
      at improving both the therapy and the rehabilitation processes.
FAU - De Luca, Ciro
AU  - De Luca C
AD  - Laboratory of Morphology of Neuronal Network, Department of Public Medicine, 
      University of Campania "Luigi Vanvitelli", 80138 Napoli, Italy.
FAU - Virtuoso, Assunta
AU  - Virtuoso A
AD  - Laboratory of Morphology of Neuronal Network, Department of Public Medicine, 
      University of Campania "Luigi Vanvitelli", 80138 Napoli, Italy.
AD  - School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
FAU - Maggio, Nicola
AU  - Maggio N
AD  - Department of Neurology and Neurosurgery, Sackler Faculty of Medicine, Sagol 
      School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.
AD  - Department of Neurology and the J. Sagol Neuroscience Center, The Chaim Sheba 
      Medical Center, Tel HaShomer, Ramat Gan 5211401, Israel.
FAU - Izzo, Sara
AU  - Izzo S
AD  - Multidisciplinary Department of Medical-Surgical and Dental Specialties, Plastic 
      Surgery Unit, University of Campania "Luigi Vanvitelli", 80138 Napoli, Italy.
FAU - Papa, Michele
AU  - Papa M
AUID- ORCID: 0000-0002-6609-7453
AD  - Laboratory of Morphology of Neuronal Network, Department of Public Medicine, 
      University of Campania "Luigi Vanvitelli", 80138 Napoli, Italy.
AD  - SYSBIO Centre of Systems Biology ISBE.ITALY, University of Milano-Bicocca, 20126 
      Milano, Italy.
FAU - Colangelo, Anna Maria
AU  - Colangelo AM
AUID- ORCID: 0000-0002-7971-4289
AD  - SYSBIO Centre of Systems Biology ISBE.ITALY, University of Milano-Bicocca, 20126 
      Milano, Italy.
AD  - Laboratory of Neuroscience "R. Levi-Montalcini", Department of Biotechnology and 
      Biosciences, University of Milano-Bicocca, 20126 Milano, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201013
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Animals
MH  - Extracellular Matrix/*metabolism
MH  - Gliosis/*metabolism
MH  - Humans
MH  - Matrix Metalloproteinases/metabolism
MH  - Neurons/*metabolism
MH  - Stroke/*metabolism/pathology
PMC - PMC7589675
OTO - NOTNLM
OT  - maladaptive plasticity
OT  - matrix metalloproteinases
OT  - neuronal extracellular matrix
OT  - neurovascular unit
OT  - stroke
OT  - systems biology
COIS- The authors declare no conflict of interests.
EDAT- 2020/10/18 06:00
MHDA- 2021/02/26 06:00
PMCR- 2020/10/01
CRDT- 2020/10/17 01:03
PHST- 2020/08/18 00:00 [received]
PHST- 2020/10/02 00:00 [revised]
PHST- 2020/10/08 00:00 [accepted]
PHST- 2020/10/17 01:03 [entrez]
PHST- 2020/10/18 06:00 [pubmed]
PHST- 2021/02/26 06:00 [medline]
PHST- 2020/10/01 00:00 [pmc-release]
AID - ijms21207554 [pii]
AID - ijms-21-07554 [pii]
AID - 10.3390/ijms21207554 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Oct 13;21(20):7554. doi: 10.3390/ijms21207554.