PMID- 33066842
OWN - NLM
STAT- MEDLINE
DCOM- 20210805
LR  - 20210805
IS  - 1618-0372 (Electronic)
IS  - 0065-1281 (Linking)
VI  - 122
IP  - 7
DP  - 2020 Oct
TI  - Protective effects of curcumin and Ganoderma lucidum on hippocampal damage caused 
      by the organophosphate insecticide chlorpyrifos in the developing rat brain: 
      Stereological, histopathological and immunohistochemical study.
PG  - 151621
LID - S0065-1281(20)30120-3 [pii]
LID - 10.1016/j.acthis.2020.151621 [doi]
AB  - The aim of this study is to draw attention to the possible effects of 
      chlorpyrifos exposure on the developing rat hippocampus in the prenatal period 
      and to determine whether these effects can be reduced with various antioxidant 
      substances. Pregnant rats were divided into 7 groups.; Chlorpyrifos (CPF), 
      Curcumin (CUR), Ganoderma lucidum (GNL), Chlorpyrifos + Curcumin (CPF + CUR), 
      Chlorpyrifos + Ganoderma lucidum, (CPF + GNL), SHAM and Control (C). After the 
      experiments, brain tissues were evaluated by stereological and 
      immunohistochemical methods. As a result of the stereological analyzes, it was 
      determined that the number of pyramidal neurons in the hippocampus of the CPF 
      group decreased significantly from all other groups. In contrast, the number of 
      neurons in the CPF + CUR and CPF + GNL groups was significantly higher than the 
      CPF group. In addition, immunohistochemical analyzes showed that the density of 
      cells stained with glial fibrillar acidic protein (GFAP) positive in all areas in 
      the hippocampus of the rats in the CPF group was significantly higher compared to 
      the control group, whereas in the CPF + CUR and CPF + GNL groups were less than 
      the CPF group. As a result, the exposure of CPF in the prenatal period caused 
      neurotoxicity in the brain hippocampus, whereas CUR and GNL reduced this toxicity 
      caused by CPF.
CI  - Copyright (c) 2020 Elsevier GmbH. All rights reserved.
FAU - Eronat, Kubra
AU  - Eronat K
AD  - Environmental Health Department, Science Institute, Sinop University, Sinop, 
      Turkey.
FAU - Sagir, Dilek
AU  - Sagir D
AD  - Faculty of Health Sciences, Sinop University, Sinop, Turkey. Electronic address: 
      bio_dilek@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20200909
PL  - Germany
TA  - Acta Histochem
JT  - Acta histochemica
JID - 0370320
RN  - 0 (Antioxidants)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Insecticides)
RN  - IT942ZTH98 (Curcumin)
RN  - JCS58I644W (Chlorpyrifos)
SB  - IM
MH  - Animals
MH  - Antioxidants/pharmacology
MH  - Brain/drug effects/*metabolism
MH  - Chlorpyrifos/*pharmacology
MH  - Curcumin/pharmacology
MH  - Female
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Hippocampus/*drug effects
MH  - Insecticides/*pharmacology
MH  - Male
MH  - Neurons/*metabolism
MH  - Oxidative Stress/drug effects
MH  - Rats, Wistar
MH  - Reishi/metabolism
OTO - NOTNLM
OT  - Chlorpyrifos
OT  - Curcumin
OT  - Ganoderma lucidum
OT  - Glial fibrillar acidic protein (GFAP)
OT  - Hippocampus
OT  - Neurotoxicity
EDAT- 2020/10/18 06:00
MHDA- 2021/08/06 06:00
CRDT- 2020/10/17 05:19
PHST- 2020/06/24 00:00 [received]
PHST- 2020/08/27 00:00 [revised]
PHST- 2020/08/28 00:00 [accepted]
PHST- 2020/10/17 05:19 [entrez]
PHST- 2020/10/18 06:00 [pubmed]
PHST- 2021/08/06 06:00 [medline]
AID - S0065-1281(20)30120-3 [pii]
AID - 10.1016/j.acthis.2020.151621 [doi]
PST - ppublish
SO  - Acta Histochem. 2020 Oct;122(7):151621. doi: 10.1016/j.acthis.2020.151621. Epub 
      2020 Sep 9.