PMID- 33067461
OWN - NLM
STAT- MEDLINE
DCOM- 20201116
LR  - 20201116
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 11
IP  - 1
DP  - 2020 Oct 16
TI  - A causal role for frontal cortico-cortical coordination in social action 
      monitoring.
PG  - 5233
LID - 10.1038/s41467-020-19026-y [doi]
LID - 5233
AB  - Decision-making via monitoring others' actions is a cornerstone of interpersonal 
      exchanges. Although the ventral premotor cortex (PMv) and the medial prefrontal 
      cortex (MPFC) are cortical nodes in social brain networks, the two areas are 
      rarely concurrently active in neuroimaging, inviting the hypothesis that they are 
      functionally independent. Here we show in macaques that the ability of the MPFC 
      to monitor others' actions depends on input from the PMv. We found that 
      delta-band coherence between the two areas emerged during action execution and 
      action observation. Information flow especially in the delta band increased from 
      the PMv to the MPFC as the biological nature of observed actions increased. 
      Furthermore, selective blockade of the PMv-to-MPFC pathway using a double viral 
      vector infection technique impaired the processing of observed, but not executed, 
      actions. These findings demonstrate that coordinated activity in the PMv-to-MPFC 
      pathway has a causal role in social action monitoring.
FAU - Ninomiya, Taihei
AU  - Ninomiya T
AUID- ORCID: 0000-0002-6098-9637
AD  - Division of Behavioral Development, Department of System Neuroscience, National 
      Institute for Physiological Sciences, National Institutes of Natural Sciences, 38 
      Myodaiji, Okazaki, Aichi, 444-8585, Japan.
AD  - Department of Physiological Sciences, School of Life Science, The Graduate 
      University for Advanced Studies (SOKENDAI), Hayama, Kanagawa, 240-0193, Japan.
FAU - Noritake, Atsushi
AU  - Noritake A
AD  - Division of Behavioral Development, Department of System Neuroscience, National 
      Institute for Physiological Sciences, National Institutes of Natural Sciences, 38 
      Myodaiji, Okazaki, Aichi, 444-8585, Japan.
AD  - Department of Physiological Sciences, School of Life Science, The Graduate 
      University for Advanced Studies (SOKENDAI), Hayama, Kanagawa, 240-0193, Japan.
FAU - Kobayashi, Kenta
AU  - Kobayashi K
AUID- ORCID: 0000-0002-7389-3693
AD  - Department of Physiological Sciences, School of Life Science, The Graduate 
      University for Advanced Studies (SOKENDAI), Hayama, Kanagawa, 240-0193, Japan.
AD  - Section of Viral Vector Development, National Institute for Physiological 
      Sciences, National Institutes of Natural Sciences, 38 Myodaiji, Okazaki, Aichi, 
      444-8585, Japan.
FAU - Isoda, Masaki
AU  - Isoda M
AUID- ORCID: 0000-0002-5094-6254
AD  - Division of Behavioral Development, Department of System Neuroscience, National 
      Institute for Physiological Sciences, National Institutes of Natural Sciences, 38 
      Myodaiji, Okazaki, Aichi, 444-8585, Japan. isodam@nips.ac.jp.
AD  - Department of Physiological Sciences, School of Life Science, The Graduate 
      University for Advanced Studies (SOKENDAI), Hayama, Kanagawa, 240-0193, Japan. 
      isodam@nips.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201016
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
SB  - IM
MH  - Animals
MH  - Brain Mapping
MH  - Decision Making
MH  - Macaca/*physiology/psychology
MH  - Male
MH  - Motor Cortex/chemistry/diagnostic imaging/*physiology
MH  - Neural Pathways
MH  - Prefrontal Cortex/chemistry/diagnostic imaging/*physiology
MH  - Social Behavior
PMC - PMC7568569
COIS- The authors declare no competing interests.
EDAT- 2020/10/18 06:00
MHDA- 2020/11/18 06:00
PMCR- 2020/10/16
CRDT- 2020/10/17 05:26
PHST- 2020/04/14 00:00 [received]
PHST- 2020/09/25 00:00 [accepted]
PHST- 2020/10/17 05:26 [entrez]
PHST- 2020/10/18 06:00 [pubmed]
PHST- 2020/11/18 06:00 [medline]
PHST- 2020/10/16 00:00 [pmc-release]
AID - 10.1038/s41467-020-19026-y [pii]
AID - 19026 [pii]
AID - 10.1038/s41467-020-19026-y [doi]
PST - epublish
SO  - Nat Commun. 2020 Oct 16;11(1):5233. doi: 10.1038/s41467-020-19026-y.