PMID- 33067707
OWN - NLM
STAT- MEDLINE
DCOM- 20210531
LR  - 20220202
IS  - 2509-2723 (Electronic)
IS  - 2509-2715 (Print)
IS  - 2509-2723 (Linking)
VI  - 43
IP  - 1
DP  - 2021 Feb
TI  - Internalize at your peril: internalizing disorders as risk factors for 
      dementia-cohort study.
PG  - 253-261
LID - 10.1007/s11357-020-00285-y [doi]
AB  - Few studies examined comorbid anxiety and depression's independent association 
      with dementia. We assessed internalizing disorders as risk factors for dementia 
      to avoid pitfalls inherent in separating anxiety and depression. Retrospectively 
      designed prospective comparative cohort study using New Zealand's (NZ) National 
      Minimum Dataset of hospital discharges. Hazards ratios (HRs), estimated from 
      parametric survival models, compared the time to incident dementia after a 
      minimal latency interval of 10 years between those with and without prior 
      diagnosis of an internalizing disorder. A total of 47,932 patients aged 
      50-54 years were discharged from a publicly funded hospital events in NZ between 
      1988 and 1992. Of these, 37,631 (79%) met eligibility criteria, and incident 
      dementia was diagnosed in 1594. Rates of incident dementia were higher among 
      patients with an earlier diagnosis of internalizing disorders (572 vs 303 per 
      100,000 person years at risk (PYAR)). After adjustment for age, sex, ethnicity, 
      and region, those with internalizing disorders were estimated to have a higher 
      risk of developing dementia than those without (adjusted HR = 1.57, 95% CI 
      1.17-2.10). Females with an earlier diagnosis of internalizing disorders were 
      estimated to have almost twice the risk of developing dementia (adjusted HR 1.80, 
      95% CI 1.25-2.59). Internalizing disorders affect one in five adults globally. 
      Our findings suggest a significant increase in risk of dementia more than 
      10 years after the diagnosis of internalizing disorder.
FAU - Barak, Yoram
AU  - Barak Y
AUID- ORCID: 0000-0002-8271-4255
AD  - School of Medicine, Dept. of Psychological Medicine, University of Otago, PO Box 
      56, Dunedin, New Zealand. Yoram.Barak@otago.ac.nz.
FAU - Barson, David
AU  - Barson D
AD  - School of Medicine, Department of Preventive and Social Medicine, University of 
      Otago, Dunedin, New Zealand.
FAU - Davie, Gabrielle
AU  - Davie G
AD  - School of Medicine, Department of Preventive and Social Medicine, University of 
      Otago, Dunedin, New Zealand.
FAU - Glue, Paul
AU  - Glue P
AD  - School of Medicine, Dept. of Psychological Medicine, University of Otago, PO Box 
      56, Dunedin, New Zealand.
FAU - Paleacu, Diana
AU  - Paleacu D
AD  - Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201016
PL  - Switzerland
TA  - Geroscience
JT  - GeroScience
JID - 101686284
SB  - IM
MH  - Cohort Studies
MH  - *Dementia/epidemiology/etiology
MH  - Female
MH  - Humans
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC8050167
OTO - NOTNLM
OT  - Dementia
OT  - Internalizing disorders
OT  - Risk
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/10/18 06:00
MHDA- 2021/06/01 06:00
PMCR- 2020/10/16
CRDT- 2020/10/17 05:30
PHST- 2020/06/04 00:00 [received]
PHST- 2020/10/12 00:00 [accepted]
PHST- 2020/10/18 06:00 [pubmed]
PHST- 2021/06/01 06:00 [medline]
PHST- 2020/10/17 05:30 [entrez]
PHST- 2020/10/16 00:00 [pmc-release]
AID - 10.1007/s11357-020-00285-y [pii]
AID - 285 [pii]
AID - 10.1007/s11357-020-00285-y [doi]
PST - ppublish
SO  - Geroscience. 2021 Feb;43(1):253-261. doi: 10.1007/s11357-020-00285-y. Epub 2020 
      Oct 16.