PMID- 33067739
OWN - NLM
STAT- MEDLINE
DCOM- 20210823
LR  - 20211204
IS  - 1573-6881 (Electronic)
IS  - 0145-479X (Linking)
VI  - 52
IP  - 6
DP  - 2020 Dec
TI  - Actin-like 6A enhances the proliferative and invasive capacities of laryngeal 
      squamous cell carcinoma by potentiating the activation of YAP signaling.
PG  - 453-463
LID - 10.1007/s10863-020-09855-3 [doi]
AB  - Overexpression of Actin-like 6A (ACTL6A) has been observed in a wide spectrum of 
      tumors and exerts an outstanding oncogenic function throughout cancer 
      progression. However, the detailed relevance of ACTL6A for laryngeal squamous 
      cell carcinoma (LSCC) is not fully understood. In this work, we aimed to 
      elucidate the precise role of ACTL6A in LSCC. Here, we show that ACTL6A 
      expression was significantly upregulated in LSCC versus normal tissues. In vitro 
      functional assays demonstrated that silencing of ACTL6A significantly diminished 
      the capacity of LSCC cells to proliferate and invade, whilst up-regulation of 
      ACTL6A drove proliferation and invasion in LSCC cells. Further investigation 
      revealed that knockdown of ACTL6A repressed the activation of Yes-associated 
      protein (YAP)-mediated signaling in LSCC cells, while reactivation of YAP 
      markedly reversed ACTL6A-silencing-mediated inhibition of proliferation and 
      invasion in LSCC cells. Moreover, suppression of YAP markedly diminished 
      ACTL6A-overexpression-induced promotion of tumor formation in LSCC. In addition, 
      ACTL6A silencing diminished the tumorigenicity of LSCC cells in vivo. To 
      summarize, our work indicates that ACTL6A may enhance LSCC progression via 
      potentiating the activation of YAP signaling. Thus, ACTL6A may be an attractive 
      anticancer target for the treatment of LSCC.
FAU - Dang, Yabin
AU  - Dang Y
AD  - Department of Otolaryngology, Xianyang Hospital of Yan'an University, Xianyang 
      City, 712000, Shaanxi Province, China.
FAU - Zhang, Ligang
AU  - Zhang L
AD  - Department of Otolaryngology, Xianyang Hospital of Yan'an University, Xianyang 
      City, 712000, Shaanxi Province, China.
FAU - Wang, Xiaoyan
AU  - Wang X
AUID- ORCID: 0000-0003-3359-1209
AD  - Department of Otolaryngology, Xianyang Central Hospital, 78 Renmin East Road, 
      Xianyang City, 712000, Shaanxi Province, China. wxy2390158@163.com.
LA  - eng
PT  - Journal Article
DEP - 20201016
PL  - United States
TA  - J Bioenerg Biomembr
JT  - Journal of bioenergetics and biomembranes
JID - 7701859
RN  - 0 (ACTL6A protein, human)
RN  - 0 (Actins)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Chromosomal Proteins, Non-Histone)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (YAP1 protein, human)
SB  - IM
MH  - Actins/*metabolism
MH  - Adaptor Proteins, Signal Transducing/*metabolism
MH  - Animals
MH  - Cell Line, Tumor
MH  - Cell Proliferation/physiology
MH  - Chromosomal Proteins, Non-Histone/*metabolism
MH  - DNA-Binding Proteins/*metabolism
MH  - Heterografts
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - Neoplasm Invasiveness
MH  - Signal Transduction
MH  - Squamous Cell Carcinoma of Head and Neck/*metabolism/pathology
MH  - Transcription Factors/*metabolism
MH  - YAP-Signaling Proteins
OTO - NOTNLM
OT  - Actin-like 6A
OT  - Laryngeal squamous cell carcinoma
OT  - YAP
EDAT- 2020/10/18 06:00
MHDA- 2021/08/24 06:00
CRDT- 2020/10/17 05:30
PHST- 2020/09/04 00:00 [received]
PHST- 2020/10/11 00:00 [accepted]
PHST- 2020/10/18 06:00 [pubmed]
PHST- 2021/08/24 06:00 [medline]
PHST- 2020/10/17 05:30 [entrez]
AID - 10.1007/s10863-020-09855-3 [pii]
AID - 10.1007/s10863-020-09855-3 [doi]
PST - ppublish
SO  - J Bioenerg Biomembr. 2020 Dec;52(6):453-463. doi: 10.1007/s10863-020-09855-3. 
      Epub 2020 Oct 16.