PMID- 33067949
OWN - NLM
STAT- MEDLINE
DCOM- 20201020
LR  - 20201020
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 28
IP  - 5
DP  - 2020 Oct
TI  - [Analysis of Clinical Characteristics in De novo Chronic Myelogenous Leukemia 
      Patients with Extramedullary T-Lymphoblastic Blast Crisis].
PG  - 1528-1533
LID - 10.19746/j.cnki.issn.1009-2137.2020.05.017 [doi]
AB  - OBJECTIVE: To report the clinical characteristics in a case of extramedullary 
      T-lymphoblastic blast crisis of de novo chronic myelogenous leukemia (CML) so as 
      to improve the understanding of this disease. METHODS: The clinical 
      characteristics, diagnostic approach and treatment of the patient were 
      retrospectively analyzed, and some related literatures were reviewed. RESULTS: 
      According to resuts of blood routine, bone marrow, chromosome and fusion gene 
      tests, this patient was considered to be CML patient. The cervical lymph node 
      biopsy indicated a T-cell lymphoblastic lymphoma (TLBL), and fluorescence in situ 
      hybridization (FISH) analysis showed the BCR-ABL fusion gene within tumor cells 
      of the patient's lymphnodes, thus was confirmedly diagnosed as extramedullary 
      T-lymphoblastic blast crisis of chronic myelogenous leukemia. Treatment with 
      dasatinib 140 mg/d combined with chemotherapy was then initiated, while the 
      patient never achieved a complete remission. CONCLUSION: De novo chronic 
      myelogenous leukemia in blast crisis is infrequent presence, the cases of 
      extramedullary T-lymphoblastic blast crisis of newly diagnosed CML with 
      additional chromosome 11q23 are extremely rare. And prognosis of these patients 
      are poor, allogeneic hematopoietic stem cell transplantation maybe the only 
      curable treatment.
FAU - Guan, Yan
AU  - Guan Y
AD  - Department of Hematology, Yijishan Hospital of Wannan Medical College, Wuhu 
      241001, Anhui Province, China.
FAU - Liu, Qiong
AU  - Liu Q
AD  - Department of Hematology, Yijishan Hospital of Wannan Medical College, Wuhu 
      241001, Anhui Province, China.
FAU - Huang, Dong-Ping
AU  - Huang DP
AD  - Department of Hematology, Yijishan Hospital of Wannan Medical College, Wuhu 
      241001, Anhui Province, China.
FAU - He, He-Sheng
AU  - He HS
AD  - Department of Hematology, Yijishan Hospital of Wannan Medical College, Wuhu 
      241001, Anhui Province, China,E-mail: hhsmed2012@126.com.
LA  - chi
PT  - Case Reports
PT  - Journal Article
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
SB  - IM
MH  - *Blast Crisis
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Leukemia, Myelogenous, Chronic, BCR-ABL Positive
MH  - Lymphocytes
MH  - Retrospective Studies
EDAT- 2020/10/18 06:00
MHDA- 2020/10/21 06:00
CRDT- 2020/10/17 08:33
PHST- 2020/10/17 08:33 [entrez]
PHST- 2020/10/18 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
AID - 1009-2137(2020)05-1528-06 [pii]
AID - 10.19746/j.cnki.issn.1009-2137.2020.05.017 [doi]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Oct;28(5):1528-1533. doi: 
      10.19746/j.cnki.issn.1009-2137.2020.05.017.