PMID- 33068586
OWN - NLM
STAT- MEDLINE
DCOM- 20210419
LR  - 20220102
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 192
DP  - 2021 Jan
TI  - Prenatal maternal phthalate exposures and child lipid and adipokine levels at age 
      six: A study from the PROGRESS cohort of Mexico City.
PG  - 110341
LID - S0013-9351(20)31238-X [pii]
LID - 10.1016/j.envres.2020.110341 [doi]
AB  - BACKGROUND: Prenatal phthalate exposures may affect processes that underlie 
      offspring cardiometabolic health, but findings from studies examining these 
      associations are conflicting. We examined associations between biomarkers of 
      phthalate exposures during pregnancy with child lipid and adipokine levels. 
      METHODS: Data were from 463 mother-child pairs in the PROGRESS cohort of Mexico 
      City. We quantified 15 phthalate metabolites in 2nd and 3rd trimester maternal 
      urine samples and created an average pregnancy measure using the geometric mean. 
      We evaluated the 15 metabolites as nine biomarkers, including four metabolite 
      molar sums. We measured fasting serum triglycerides, non-HDL cholesterol, leptin, 
      and adiponectin in children at the six-year follow-up visit (mean = 6.8 years). 
      We estimated associations using linear regression, Bayesian kernel machine 
      regression (BKMR), and weighted quantile sum (WQS) and assessed effect 
      modification by sex. RESULTS: In BKMR and WQS models, higher concentrations of 
      the total mixture of phthalate biomarkers were associated with lower 
      triglycerides (beta = -3.7% [-6.5, -0.78] per 1 unit increase in WQS biomarker 
      index) and non-HDL cholesterol (beta = -2.0 [-3.7, -0.25] ng/ml per increase in WQS 
      biomarker index). Associations between individual biomarkers and child outcomes 
      were largely null. We observed some evidence of effect modification by child sex 
      for mono-3-carboxypropyl phthalate (beta = 19.4% [1.26, 40.7] per doubling of 
      phthalate) and monobenzyl phthalate (beta = -7.6% [-14.4, -0.23]) in girls for 
      adiponectin. CONCLUSIONS: Individual prenatal phthalate biomarkers were not 
      associated with child lipid or adipokine levels. Contrary to our hypothesis, the 
      total phthalate mixture was associated with lower child triglycerides and non-HDL 
      cholesterol.
CI  - Copyright (c) 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Kupsco, Allison
AU  - Kupsco A
AD  - Department of Environmental Health Sciences, Mailman School of Public Health, 
      Columbia University Medical Center, New York, NY, USA. Electronic address: 
      Ak4181@cumc.columbia.edu.
FAU - Wu, Haotian
AU  - Wu H
AD  - Department of Environmental Health Sciences, Mailman School of Public Health, 
      Columbia University Medical Center, New York, NY, USA.
FAU - Calafat, Antonia M
AU  - Calafat AM
AD  - National Center for Environmental Health, Centers for Disease Control and 
      Prevention, Atlanta, GA, USA.
FAU - Kioumourtzoglou, Marianthi-Anna
AU  - Kioumourtzoglou MA
AD  - Department of Environmental Health Sciences, Mailman School of Public Health, 
      Columbia University Medical Center, New York, NY, USA.
FAU - Tamayo-Ortiz, Marcela
AU  - Tamayo-Ortiz M
AD  - Center for Research on Nutrition and Health, National Institute of Public Health, 
      Cuernavaca, Morelos, Mexico; National Council of Science and Technology, Mexico.
FAU - Pantic, Ivan
AU  - Pantic I
AD  - National Institute of Perinatology, Mexico City, Mexico.
FAU - Cantoral, Alejandra
AU  - Cantoral A
AD  - Center for Research on Nutrition and Health, National Institute of Public Health, 
      Cuernavaca, Morelos, Mexico.
FAU - Tolentino, Maricruz
AU  - Tolentino M
AD  - National Institute of Perinatology, Mexico City, Mexico.
FAU - Oken, Emily
AU  - Oken E
AD  - Division of Chronic Disease Research Across the Lifecourse, Department of 
      Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care 
      Institute, Boston, MA, USA.
FAU - Braun, Joseph M
AU  - Braun JM
AD  - Department of Epidemiology, Brown University, Providence, RI, USA.
FAU - Deierlein, Andrea L
AU  - Deierlein AL
AD  - Department of Epidemiology, School of Global Public Health, New York University, 
      New York, NY, USA.
FAU - Wright, Robert O
AU  - Wright RO
AD  - Department of Environmental Medicine and Public Health, Icahn School of Medicine 
      at Mount Sinai, New York, NY, USA.
FAU - Tellez-Rojo, Martha M
AU  - Tellez-Rojo MM
AD  - Center for Research on Nutrition and Health, National Institute of Public Health, 
      Cuernavaca, Morelos, Mexico.
FAU - Baccarelli, Andrea A
AU  - Baccarelli AA
AD  - Department of Environmental Health Sciences, Mailman School of Public Health, 
      Columbia University Medical Center, New York, NY, USA.
FAU - Just, Allan C
AU  - Just AC
AD  - Department of Environmental Medicine and Public Health, Icahn School of Medicine 
      at Mount Sinai, New York, NY, USA.
LA  - eng
GR  - R01 ES021357/ES/NIEHS NIH HHS/United States
GR  - R01 ES013744/ES/NIEHS NIH HHS/United States
GR  - R24 ES028522/ES/NIEHS NIH HHS/United States
GR  - P30 ES023515/ES/NIEHS NIH HHS/United States
GR  - R01 ES028805/ES/NIEHS NIH HHS/United States
GR  - R00 ES023450/ES/NIEHS NIH HHS/United States
GR  - P30 ES009089/ES/NIEHS NIH HHS/United States
GR  - R00 ES023474/ES/NIEHS NIH HHS/United States
GR  - R01 ES024381/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20201014
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Adipokines)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Lipids)
RN  - 0 (Phthalic Acids)
RN  - 6O7F7IX66E (phthalic acid)
SB  - IM
MH  - Adipokines
MH  - Bayes Theorem
MH  - Child
MH  - Environmental Exposure
MH  - *Environmental Pollutants
MH  - Female
MH  - Humans
MH  - Lipids
MH  - Mexico
MH  - *Phthalic Acids
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/chemically induced/epidemiology
PMC - PMC7736226
MID - NIHMS1637934
OTO - NOTNLM
OT  - Cardiometabolic risk
OT  - Children's health
OT  - Lipids
OT  - Phthalates
OT  - Prenatal exposures
COIS- Declaration of interests The authors declare that they have no known competing 
      financial interests or personal relationships that could have appeared to 
      influence the work reported in this paper.
EDAT- 2020/10/18 06:00
MHDA- 2021/04/20 06:00
PMCR- 2022/01/01
CRDT- 2020/10/17 20:07
PHST- 2020/07/09 00:00 [received]
PHST- 2020/09/30 00:00 [revised]
PHST- 2020/10/11 00:00 [accepted]
PHST- 2020/10/18 06:00 [pubmed]
PHST- 2021/04/20 06:00 [medline]
PHST- 2020/10/17 20:07 [entrez]
PHST- 2022/01/01 00:00 [pmc-release]
AID - S0013-9351(20)31238-X [pii]
AID - 10.1016/j.envres.2020.110341 [doi]
PST - ppublish
SO  - Environ Res. 2021 Jan;192:110341. doi: 10.1016/j.envres.2020.110341. Epub 2020 
      Oct 14.