PMID- 33068778
OWN - NLM
STAT- MEDLINE
DCOM- 20211118
LR  - 20220304
IS  - 1525-0024 (Electronic)
IS  - 1525-0016 (Print)
IS  - 1525-0016 (Linking)
VI  - 29
IP  - 3
DP  - 2021 Mar 3
TI  - lncRNA SNHG11 Promotes Gastric Cancer Progression by Activating the Wnt/beta-Catenin 
      Pathway and Oncogenic Autophagy.
PG  - 1258-1278
LID - S1525-0016(20)30545-1 [pii]
LID - 10.1016/j.ymthe.2020.10.011 [doi]
AB  - Long non-coding RNAs (lncRNAs) are under active investigation in the development 
      of cancers, including gastric cancer (GC). Oncogenic autophagy is required for 
      cancer cell survival. The present study aimed to investigate the regulatory role 
      of lncRNA small nucleolar host gene 11 (SNHG11) in GC. We show that SNHG11 is 
      upregulated in GC, and that its upregulation correlated with dismal patient 
      outcomes. Functionally, SNHG11 aggravated oncogenic autophagy to facilitate cell 
      proliferation, stemness, migration, invasion, and epithelial-to-mesenchymal 
      transition (EMT) in GC. Mechanistically, SNHG11 post-transcriptionally 
      upregulated catenin beta 1 (CTNNB1) and autophagy related 12 (ATG12) through 
      miR-483-3p/miR-1276, while the processing of precursor (pre-)miR-483/pre-miR-1276 
      was hindered by SNHG11. SNHG11 induced GSK-3beta ubiquitination through interacting 
      with Cullin 4A (CUL4A) to further activate the Wnt/beta-catenin pathway. 
      Intriguingly, SNHG11 regulated autophagy in a manner dependent on ATG12 rather 
      than the Wnt/beta-catenin pathway, whereas SNHG11 contributed to the malignant 
      behaviors of GC cells via both pathways. Finally, SNHG11 upregulation in GC cells 
      was shown to be transcriptionally induced by TCF7L2. In conclusion, we reveal 
      that SNHG11 is an onco-lncRNA in GC and might be a promising prognostic and 
      therapeutic target for GC.
CI  - Copyright (c) 2020 The American Society of Gene and Cell Therapy. Published by 
      Elsevier Inc. All rights reserved.
FAU - Wu, Qiong
AU  - Wu Q
AD  - Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University 
      School of Medicine, 1111 Xianxia Road, Shanghai 200336, China.
FAU - Ma, Jiali
AU  - Ma J
AD  - Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University 
      School of Medicine, 1111 Xianxia Road, Shanghai 200336, China.
FAU - Wei, Jue
AU  - Wei J
AD  - Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University 
      School of Medicine, 1111 Xianxia Road, Shanghai 200336, China.
FAU - Meng, Wenying
AU  - Meng W
AD  - Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University 
      School of Medicine, 1111 Xianxia Road, Shanghai 200336, China.
FAU - Wang, Yugang
AU  - Wang Y
AD  - Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University 
      School of Medicine, 1111 Xianxia Road, Shanghai 200336, China. Electronic 
      address: wyg0061@shtrhospital.com.
FAU - Shi, Min
AU  - Shi M
AD  - Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University 
      School of Medicine, 1111 Xianxia Road, Shanghai 200336, China. Electronic 
      address: sm1790@shtrhospital.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201015
PL  - United States
TA  - Mol Ther
JT  - Molecular therapy : the journal of the American Society of Gene Therapy
JID - 100890581
RN  - 0 (ATG12 protein, human)
RN  - 0 (Autophagy-Related Protein 12)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CTNNB1 protein, human)
RN  - 0 (CUL4A protein, human)
RN  - 0 (Cullin Proteins)
RN  - 0 (MIRN-1276 microRNA, human)
RN  - 0 (MIRN483 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (WNT1 protein, human)
RN  - 0 (Wnt1 Protein)
RN  - 0 (beta Catenin)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - *Autophagy
MH  - Autophagy-Related Protein 12/genetics/metabolism
MH  - Biomarkers, Tumor/genetics/metabolism
MH  - *Carcinogenesis
MH  - Cell Proliferation
MH  - Cullin Proteins/genetics/metabolism
MH  - *Epithelial-Mesenchymal Transition
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - MicroRNAs/genetics
MH  - Prognosis
MH  - RNA, Long Noncoding/*genetics
MH  - Stomach Neoplasms/genetics/metabolism/*pathology
MH  - Survival Rate
MH  - Tumor Cells, Cultured
MH  - Wnt1 Protein/genetics/*metabolism
MH  - Xenograft Model Antitumor Assays
MH  - beta Catenin/genetics/*metabolism
PMC - PMC7934455
OTO - NOTNLM
OT  - ATG12
OT  - CTNNB1
OT  - CUL4A
OT  - SNHG11
OT  - Wnt/beta-catenin
OT  - autophagy
OT  - gastric cancer
OT  - miR-1267
OT  - miR-483-3p
OT  - ubiquitination
COIS- Declaration of Interests The authors declare no competing interests.
EDAT- 2020/10/18 06:00
MHDA- 2021/11/19 06:00
PMCR- 2022/03/03
CRDT- 2020/10/17 20:08
PHST- 2019/09/15 00:00 [received]
PHST- 2020/02/22 00:00 [revised]
PHST- 2020/10/08 00:00 [accepted]
PHST- 2020/10/18 06:00 [pubmed]
PHST- 2021/11/19 06:00 [medline]
PHST- 2020/10/17 20:08 [entrez]
PHST- 2022/03/03 00:00 [pmc-release]
AID - S1525-0016(20)30545-1 [pii]
AID - 10.1016/j.ymthe.2020.10.011 [doi]
PST - ppublish
SO  - Mol Ther. 2021 Mar 3;29(3):1258-1278. doi: 10.1016/j.ymthe.2020.10.011. Epub 2020 
      Oct 15.