PMID- 33068969 OWN - NLM STAT- MEDLINE DCOM- 20201222 LR - 20201222 IS - 1879-1298 (Electronic) IS - 0045-6535 (Linking) VI - 264 IP - Pt 2 DP - 2021 Feb TI - Association of multiple metals with lipid markers against different exposure profiles: A population-based cross-sectional study in China. PG - 128505 LID - S0045-6535(20)32700-4 [pii] LID - 10.1016/j.chemosphere.2020.128505 [doi] AB - We sought to evaluate whether essential and toxic metals are cross-sectionally related to blood lipid levels using data among adults from Shimen (n = 564) and Huayuan (n = 637), two counties with different exposure profiles in Hunan province of China. Traditional and grouped weighted quantile sum (WQS) regression and Bayesian kernel machine regression (BKMR) were performed to assess association between exposure to a mixture of 22 metals measured in urine or plasma, and lipid markers. Most of the exposure levels of metals were significantly higher in Shimen area than those in Huayuan area (all P-values < 0.001). Traditional WQS regression analyses revealed that the WQS index were both significantly associated with lipid markers in two areas, except for the HDL-C. Grouped WQS revealed that essential metals group showed significantly positive associations with lipid markers except for HDL-C in Huayuan area, while toxic metals group showed significantly negative associations except for HDL-C and LDL-C in Huayuan area. There were no significant joint effects, but potential non-linear relationships between metals mixture and TC or LDL-C levels were observed in BKMR analyses. Although consistent significantly associations of zinc and titanium with TG levels were found in both areas, the metals closely related to other lipid markers were varied by sites. Additionally, the BKMR analyses revealed an inverse U shaped association of iron with LDL-C levels and interaction effects of zinc and cadmium on LDL-C in Huayuan area. The relationship between metal exposure and blood lipid were not identical against different exposure profiles. CI - Copyright (c) 2020 Elsevier Ltd. All rights reserved. FAU - Li, Zhaoyang AU - Li Z AD - Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Xu, Yali AU - Xu Y AD - Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Huang, Zhijun AU - Huang Z AD - Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, 410013, China. FAU - Wei, Yue AU - Wei Y AD - Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Hou, Jian AU - Hou J AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, China. FAU - Long, Tengfei AU - Long T AD - Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Wang, Fei AU - Wang F AD - Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Cheng, Xu AU - Cheng X AD - Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Duan, Yanying AU - Duan Y AD - Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, 410078, China. FAU - Chen, Xiang AU - Chen X AD - Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China. FAU - Yuan, Hong AU - Yuan H AD - Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, 410013, China. FAU - Shen, Minxue AU - Shen M AD - Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, 410078, China. Electronic address: shenmx1988@csu.edu.cn. FAU - He, Meian AU - He M AD - Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: hemeian@hotmail.com. LA - eng PT - Journal Article DEP - 20201007 PL - England TA - Chemosphere JT - Chemosphere JID - 0320657 RN - 0 (Lipids) SB - IM MH - Bayes Theorem MH - China MH - Cross-Sectional Studies MH - *Environmental Exposure/analysis MH - *Lipids OTO - NOTNLM OT - Bayesian kernel machine regression (BKMR) OT - Lipid levels OT - Multi-metal exposure OT - Weighted quantile sum (WQS) regression COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2020/10/18 06:00 MHDA- 2020/12/23 06:00 CRDT- 2020/10/17 20:13 PHST- 2020/05/28 00:00 [received] PHST- 2020/09/27 00:00 [revised] PHST- 2020/09/30 00:00 [accepted] PHST- 2020/10/18 06:00 [pubmed] PHST- 2020/12/23 06:00 [medline] PHST- 2020/10/17 20:13 [entrez] AID - S0045-6535(20)32700-4 [pii] AID - 10.1016/j.chemosphere.2020.128505 [doi] PST - ppublish SO - Chemosphere. 2021 Feb;264(Pt 2):128505. doi: 10.1016/j.chemosphere.2020.128505. Epub 2020 Oct 7.