PMID- 33070043
OWN - NLM
STAT- MEDLINE
DCOM- 20201229
LR  - 20211110
IS  - 1879-1360 (Electronic)
IS  - 0022-3999 (Print)
IS  - 0022-3999 (Linking)
VI  - 139
DP  - 2020 Dec
TI  - Changes in mental health symptoms from pre-COVID-19 to COVID-19 among 
      participants with systemic sclerosis from four countries: A Scleroderma 
      Patient-centered Intervention Network (SPIN) Cohort study.
PG  - 110262
LID - S0022-3999(20)30824-2 [pii]
LID - 10.1016/j.jpsychores.2020.110262 [doi]
AB  - INTRODUCTION: No studies have reported mental health symptom comparisons prior to 
      and during COVID-19 in vulnerable medical populations. OBJECTIVE: To compare 
      anxiety and depression symptoms among people with a pre-existing medical 
      condition and factors associated with changes. METHODS: Pre-COVID-19 Scleroderma 
      Patient-centered Intervention Network Cohort data were linked to COVID-19 data 
      from April 2020. Multiple linear and logistic regression were used to assess 
      factors associated with continuous change and >/= 1 minimal clinically important 
      difference (MCID) change for anxiety (PROMIS Anxiety 4a v1.0; MCID = 4.0) and 
      depression (Patient Health Questionnaire-8; MCID = 3.0) symptoms, controlling for 
      pre-COVID-19 levels. RESULTS: Mean anxiety symptoms increased 4.9 points (95% 
      confidence interval [CI] 4.0 to 5.7). Depression symptom change was negligible 
      (0.3 points; 95% CI -0.7 to 0.2). Compared to France (N = 159), adjusted anxiety 
      symptom change scores were significantly higher in the United Kingdom (N = 50; 
      3.3 points, 95% CI 0.9 to 5.6), United States (N = 128; 2.5 points, 95% CI 0.7 to 
      4.2), and Canada (N = 98; 1.9 points, 95% CI 0.1 to 3.8). Odds of >/=1 MCID 
      increase were 2.6 for the United Kingdom (95% CI 1.2 to 5.7) but not significant 
      for the United States (1.6, 95% CI 0.9 to 2.9) or Canada (1.4, 95% CI 0.7 to 
      2.5). Older age and adequate financial resources were associated with less 
      continuous anxiety increase. Employment and shorter time since diagnosis were 
      associated with lower odds of a >/= 1 MCID increase. CONCLUSIONS: Anxiety symptoms, 
      but not depression symptoms, increased dramatically during COVID-19 among people 
      with a pre-existing medical condition.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Thombs, Brett D
AU  - Thombs BD
AD  - Lady Davis Institute for Medical Research, Jewish General Hospital, 4333 Chemin 
      de la Cote-Sainte-Catherine, Montreal, Quebec H3T 1E4, Canada; Department of 
      Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec H3A 1A1, 
      Canada; Department of Epidemiology, Biostatistics, and Occupational Health, 
      McGill University, 1020 Pine Avenue West, Montreal, Quebec H3A 1A2, Canada; 
      Department of Medicine, McGill University, 1001 Decarie Boulevard, Montreal, 
      Quebec H4A 3J1, Canada; Department of Psychology, McGill University, 2001 McGill 
      College Avenue, Montreal, Quebec H3A 1G1, Canada; Department of Educational and 
      Counselling Psychology, McGill University, 3700 McTavish Street, Montreal, Quebec 
      H3A 1Y2, Canada; Biomedical Ethics Unit, McGill University, 3647 Peel Street, 
      Montreal, Quebec H3A 1X1, Canada. Electronic address: brett.thombs@mcgill.ca.
FAU - Kwakkenbos, Linda
AU  - Kwakkenbos L
AD  - Department of Clinical Psychology, Behavioural Science Institute, Radboud 
      University, Montessorilaan 3, 6525 HR, Nijmegen, the Netherlands.
FAU - Henry, Richard S
AU  - Henry RS
AD  - Lady Davis Institute for Medical Research, Jewish General Hospital, 4333 Chemin 
      de la Cote-Sainte-Catherine, Montreal, Quebec H3T 1E4, Canada; Department of 
      Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec H3A 1A1, 
      Canada.
FAU - Carrier, Marie-Eve
AU  - Carrier ME
AD  - Lady Davis Institute for Medical Research, Jewish General Hospital, 4333 Chemin 
      de la Cote-Sainte-Catherine, Montreal, Quebec H3T 1E4, Canada.
FAU - Patten, Scott
AU  - Patten S
AD  - Department of Community Health Sciences, University of Calgary, 3280 Hospital 
      Drive NW, Calgary, Alberta T2N 4Z6, Canada; Hotchkiss Brain Institute, University 
      of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada; O'Brien 
      Institute for Public Health, University of Calgary, 3280 Hospital Drive NW, 
      Calgary, Alberta T2N 4Z6, Canada.
FAU - Harb, Sami
AU  - Harb S
AD  - Lady Davis Institute for Medical Research, Jewish General Hospital, 4333 Chemin 
      de la Cote-Sainte-Catherine, Montreal, Quebec H3T 1E4, Canada; Department of 
      Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec H3A 1A1, 
      Canada.
FAU - Bourgeault, Angelica
AU  - Bourgeault A
AD  - Lady Davis Institute for Medical Research, Jewish General Hospital, 4333 Chemin 
      de la Cote-Sainte-Catherine, Montreal, Quebec H3T 1E4, Canada.
FAU - Tao, Lydia
AU  - Tao L
AD  - Lady Davis Institute for Medical Research, Jewish General Hospital, 4333 Chemin 
      de la Cote-Sainte-Catherine, Montreal, Quebec H3T 1E4, Canada.
FAU - Bartlett, Susan J
AU  - Bartlett SJ
AD  - Department of Medicine, McGill University, 1001 Decarie Boulevard, Montreal, 
      Quebec H4A 3J1, Canada; Research Institute of the McGill University Health 
      Centre, Centre for Outcomes Research and Evaluation, 5252 de Maisonneuve #3D.57, 
      Montreal, Quebec H4A 2S5, Canada.
FAU - Mouthon, Luc
AU  - Mouthon L
AD  - Universite Paris Descartes, Assistance Publique-Hopitaux de Paris, 3 Avenue 
      Victoria, 75004 Paris, France; Service de Medecine Interne, Centre de Reference 
      Maladies Systemiques Autoimmunes Rares d'Ile de France, Hopital Cochin, 
      Assistance Publique - Hopitaux de Paris, 27 Rue du Faubourg Saint-Jacques, 75014 
      Paris, France.
FAU - Varga, John
AU  - Varga J
AD  - Northwestern Scleroderma Program, Feinberg School of Medicine, Northwestern 
      University, 675 North St. Clair, Chicago, IL 60611, USA.
FAU - Benedetti, Andrea
AU  - Benedetti A
AD  - Department of Epidemiology, Biostatistics, and Occupational Health, McGill 
      University, 1020 Pine Avenue West, Montreal, Quebec H3A 1A2, Canada; Department 
      of Medicine, McGill University, 1001 Decarie Boulevard, Montreal, Quebec H4A 3J1, 
      Canada; Respiratory Epidemiology and Clinical Research Unit, McGill University 
      Health Centre, 5252 boulevard de Maisonneuve, Montreal, Quebec H4A 3S5, Canada.
CN  - SPIN Patient Advisors
CN  - SPIN Investigators
LA  - eng
GR  - KL2 TR003168/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20201003
PL  - England
TA  - J Psychosom Res
JT  - Journal of psychosomatic research
JID - 0376333
SB  - IM
MH  - Adult
MH  - Aged
MH  - COVID-19/epidemiology/*psychology/therapy
MH  - Canada/epidemiology
MH  - Cohort Studies
MH  - Female
MH  - France/epidemiology
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Mental Disorders/epidemiology/*psychology/therapy
MH  - Mental Health/*trends
MH  - Middle Aged
MH  - Patient-Centered Care/methods/*trends
MH  - Scleroderma, Systemic/epidemiology/*psychology/therapy
MH  - United Kingdom/epidemiology
MH  - United States/epidemiology
PMC - PMC7532799
OTO - NOTNLM
OT  - Adult
OT  - Anxiety
OT  - COVID-19
OT  - Clinical epidemiology
OT  - Depressed mood
OT  - Depressive symptoms
OT  - Epidemiology
OT  - Pandemic
OT  - Scleroderma
OT  - Systemic sclerosis
COIS- All authors have completed the ICJME uniform disclosure form. Dr. Mouthon 
      reported personal fees from Actelion/Johnson & Johnson, grants from LFB, 
      non-financial support from Octapharma, and non-financial support from Grifols, 
      all outside the submitted work. All other authors declared: no support from any 
      organization for the submitted work; no financial relationships with any 
      organisations that might have an interest in the submitted work in the previous 
      three years; no other relationships or activities that could appear to have 
      influenced the submitted work.
FIR - Fortune, Catherine
IR  - Fortune C
IRAD- Scleroderma Society of Ontario, Hamilton, Ontario, Canada.
FIR - Gietzen, Amy
IR  - Gietzen A
IRAD- Scleroderma Foundation, Tri-State Chapter, Binghamton, NY, USA.
FIR - Guillot, Genevieve
IR  - Guillot G
IRAD- Sclerodermie Quebec, Longueuil, Quebec, Canada.
FIR - Lewis, Nancy
IR  - Lewis N
IRAD- Toronto, Ontario, Canada.
FIR - Richard, Michelle
IR  - Richard M
IRAD- Scleroderma Atlantic, Halifax, Nova Scotia, Canada.
FIR - Sauve, Maureen
IR  - Sauve M
IRAD- Scleroderma Society of Ontario, Hamilton, Ontario, Canada.
FIR - Welling, Joep
IR  - Welling J
IRAD- NVLE Dutch Patient Organization for Systemic Autoimmune Diseases, Utrecht, the 
      Netherlands.
FIR - Fligelstone, Kim
IR  - Fligelstone K
IRAD- Scleroderma & Raynaud's UK, London, United Kingdom.
FIR - Gottesman, Karen
IR  - Gottesman K
IRAD- Scleroderma Foundation, Tri-State Chapter, Binghamton, NY, USA.
FIR - Leite, Catarina
IR  - Leite C
IRAD- University of Minho, Braga, Portugal.
FIR - Perez, Elisabet
IR  - Perez E
IRAD- Asociacion Espanola de Esclerodermia, Madrid, Spain.
FIR - Baron, Murray
IR  - Baron M
IRAD- McGill University, Montreal, Quebec, Canada.
FIR - Malcarne, Vanessa
IR  - Malcarne V
IRAD- San Diego State University, San Diego, CA, USA.
FIR - Mayes, Maureen D
IR  - Mayes MD
IRAD- University of Texas McGovern School of Medicine, Houston, TX, USA.
FIR - Nielson, Warren R
IR  - Nielson WR
IRAD- St. Joseph's Health Care, London, ON, Canada.
FIR - Riggs, Robert
IR  - Riggs R
IRAD- San Diego State University, San Diego, CA, USA.
FIR - Assassi, Shervin
IR  - Assassi S
IRAD- University of Texas McGovern School of Medicine, Houston, TX, USA.
FIR - Ells, Carolyn
IR  - Ells C
IRAD- McGill University, Montreal, Quebec, Canada.
FIR - van den Ende, Cornelia
IR  - van den Ende C
IRAD- Sint Maartenskliniek, Nijmegen, the Netherlands.
FIR - Frech, Tracy
IR  - Frech T
IRAD- University of Utah, Salt Lake City, UT, USA.
FIR - Harel, Daphna
IR  - Harel D
IRAD- New York University, New York, New York, USA.
FIR - Hinchcliff, Monique
IR  - Hinchcliff M
IRAD- Yale School of Medicine, New Haven, CT, USA.
FIR - Hudson, Marie
IR  - Hudson M
IRAD- McGill University, Montreal, Quebec, Canada.
FIR - Johnson, Sindhu R
IR  - Johnson SR
IRAD- Toronto Scleroderma Program, Mount Sinai Hospital, Toronto Western Hospital, 
      Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada.
FIR - Larche, Maggie
IR  - Larche M
IRAD- McMaster University, Hamilton, Ontario, Canada.
FIR - Nguyen, Christelle
IR  - Nguyen C
IRAD- Universite Paris Descartes, Paris, France; Assistance Publique - Hopitaux de 
      Paris, Hopital Cochin, Paris, France.
FIR - Pope, Janet
IR  - Pope J
IRAD- University of Western Ontario, London, Ontario, Canada.
FIR - Rannou, Francois
IR  - Rannou F
IRAD- Universite Paris Descartes, Paris, France.
FIR - Reyna, Tatiana Sofia Rodriguez
IR  - Reyna TSR
IRAD- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, 
      Mexico.
FIR - Schouffoer, Anne A
IR  - Schouffoer AA
IRAD- Leiden University Medical Center, Leiden, the Netherlands.
FIR - Suarez-Almazor, Maria E
IR  - Suarez-Almazor ME
IRAD- University of Texas MD Anderson Cancer Center, Houston, TX, USA.
FIR - Agard, Christian
IR  - Agard C
IRAD- Centre Hospitalier Universitaire - Hotel-Dieu de Nantes, Nantes, France.
FIR - Albert, Alexandra
IR  - Albert A
IRAD- Universite Laval, Quebec, Quebec, Canada.
FIR - Bernstein, Elana J
IR  - Bernstein EJ
IRAD- Columbia University, New York, NY, USA.
FIR - Berthier, Sabine
IR  - Berthier S
IRAD- Centre Hospitalier Universitaire - Hotel-Dieu de Nantes, Nantes, France.
FIR - Bissonnette, Lyne
IR  - Bissonnette L
IRAD- Universite de Sherbrooke, Sherbrooke, Quebec, Canada.
FIR - Bruns, Alessandra
IR  - Bruns A
IRAD- Universite de Sherbrooke, Sherbrooke, Quebec, Canada.
FIR - Carreira, Patricia
IR  - Carreira P
IRAD- Servicio de Reumatologia del Hospital, 12 de Octubre, Madrid, Spain.
FIR - Chaigne, Benjamin
IR  - Chaigne B
IRAD- Assistance Publique - Hopitaux de Paris, Hopital Cochin, Paris, France.
FIR - Chung, Lorinda
IR  - Chung L
IRAD- Stanford University, Stanford, CA, USA.
FIR - Correia, Chase
IR  - Correia C
IRAD- Northwestern University, Chicago, IL, USA.
FIR - Denton, Christopher
IR  - Denton C
IRAD- Royal Free London Hospital, London, UK.
FIR - Domsic, Robyn
IR  - Domsic R
IRAD- University of Pittsburgh, Pittsburgh, PA, USA.
FIR - Dunne, James V
IR  - Dunne JV
IRAD- St. Paul's Hospital and University of British Columbia, Vancouver, British 
      Columbia, Canada.
FIR - Dunogue, Bertrand
IR  - Dunogue B
IRAD- Assistance Publique - Hopitaux de Paris, Hopital Cochin, Paris, France.
FIR - Farge-Bancel, Dominique
IR  - Farge-Bancel D
IRAD- Assistance Publique - Hopitaux de Paris, Hopital Cochin, Paris, France.
FIR - Fortin, Paul R
IR  - Fortin PR
IRAD- CHU de Quebec - Universite Laval, Quebec, Quebec, Canada.
FIR - Gordon, Jessica
IR  - Gordon J
IRAD- Hospital for Special Surgery, New York City, NY, USA.
FIR - Granel-Rey, Brigitte
IR  - Granel-Rey B
IRAD- Assistance Publique - Hopitaux de Paris, Hopital Cochin, Paris, France; Aix 
      Marseille Universite, Marseille, France.
FIR - Hatron, Pierre-Yves
IR  - Hatron PY
IRAD- Centre Hospitalier Regional Universitaire de Lille, Hopital Claude Huriez, Lille, 
      France.
FIR - Herrick, Ariane L
IR  - Herrick AL
IRAD- University of Manchester, Salford Royal NHS Foundation Trust, Manchester, UK.
FIR - Hoa, Sabrina
IR  - Hoa S
IRAD- Centre hospitalier de l'universite de Montreal - CHUM, Montreal, Quebec, Canada.
FIR - Jones, Niall
IR  - Jones N
IRAD- University of Alberta, Edmonton, Alberta, Canada.
FIR - Fernandes, Artur Jose de B
IR  - Fernandes AJB
IRAD- Universite de Sherbrooke, Sherbrooke, Quebec, Canada.
FIR - Kafaja, Suzanne
IR  - Kafaja S
IRAD- University of California, Los Angeles, CA, USA.
FIR - Khalidi, Nader
IR  - Khalidi N
IRAD- McMaster University, Hamilton, Ontario, Canada.
FIR - Launay, David
IR  - Launay D
IRAD- Centre Hospitalier Regional Universitaire de Lille, Hopital Claude Huriez, Lille, 
      France.
FIR - Manning, Joanne
IR  - Manning J
IRAD- Salford Royal NHS Foundation Trust, Salford, UK.
FIR - Marie, Isabelle
IR  - Marie I
IRAD- CHU Rouen, Hopital de Bois-Guillaume, Rouen, France.
FIR - Martin, Maria
IR  - Martin M
IRAD- Servicio de Reumatologia del Hospital, 12 de Octubre, Madrid, Spain; Francois 
      Maurier, Hopitaux Prives de Metz, Hopital Belle-Isle, Metz, France.
FIR - Mekinian, Arsene
IR  - Mekinian A
IRAD- Assistance Publique - Hopitaux de Paris, Hopital Cochin, Paris, France.
FIR - Melchor, Sheila
IR  - Melchor S
IRAD- Servicio de Reumatologia del Hospital, 12 de Octubre, Madrid, Spain.
FIR - Nikpour, Mandana
IR  - Nikpour M
IRAD- St Vincent's Hospital and University of Melbourne, Melbourne, Victoria, 
      Australia.
FIR - Olagne, Louis
IR  - Olagne L
IRAD- Centre Hospitalier Universitaire - Hotel-Dieu de Nantes, Nantes, France.
FIR - Proudman, Susanna
IR  - Proudman S
IRAD- Royal Adelaide Hospital and University of Adelaide, Adelaide, South Australia, 
      Australia.
FIR - Regent, Alexis
IR  - Regent A
IRAD- Assistance Publique - Hopitaux de Paris, Hopital Cochin, Paris, France.
FIR - Riviere, Sebastien
IR  - Riviere S
IRAD- Assistance Publique - Hopitaux de Paris, Hopital Cochin, Paris, France.
FIR - Robinson, David
IR  - Robinson D
IRAD- University of Manitoba, Winnipeg, Manitoba, Canada.
FIR - Rodriguez, Esther
IR  - Rodriguez E
IRAD- Servicio de Reumatologia del Hospital, 12 de Octubre, Madrid, Spain.
FIR - Roux, Sophie
IR  - Roux S
IRAD- Universite de Sherbrooke, Sherbrooke, Quebec, Canada.
FIR - Sobanski, Vincent
IR  - Sobanski V
IRAD- Centre Hospitalier Regional Universitaire de Lille, Hopital Claude Huriez, Lille, 
      France.
FIR - Steen, Virginia
IR  - Steen V
IRAD- Georgetown University, Washington, DC, USA.
FIR - Sutton, Evelyn
IR  - Sutton E
IRAD- Dalhousie University, Halifax, Nova Scotia, Canada.
FIR - Thorne, Carter
IR  - Thorne C
IRAD- Southlake Regional Health Centre, Newmarket, Ontario, Canada.
FIR - Wilcox, Pearce
IR  - Wilcox P
IRAD- St. Paul's Hospital and University of British Columbia, Vancouver, British 
      Columbia, Canada.
FIR - Ayala, Mara Canedo
IR  - Ayala MC
IRAD- Jewish General Hospital, Montreal, Quebec, Canada.
FIR - Carboni-Jimenez, Andrea
IR  - Carboni-Jimenez A
IRAD- Jewish General Hospital, Montreal, Quebec, Canada.
FIR - Gagarine, Maria
IR  - Gagarine M
IRAD- Jewish General Hospital, Montreal, Quebec, Canada.
FIR - Nordlund, Julia
IR  - Nordlund J
IRAD- Jewish General Hospital, Montreal, Quebec, Canada.
FIR - Ostbo, Nora
IR  - Ostbo N
IRAD- Jewish General Hospital, Montreal, Quebec, Canada.
FIR - Rice, Danielle B
IR  - Rice DB
IRAD- Jewish General Hospital, Montreal, Quebec, Canada.
FIR - Turner, Kimberly A
IR  - Turner KA
IRAD- Jewish General Hospital, Montreal, Quebec, Canada.
FIR - Culos-Reed, Nicole
IR  - Culos-Reed N
IRAD- University of Calgary, Alberta, Canada.
FIR - Dyas, Laura
IR  - Dyas L
IRAD- Scleroderma Foundation Michigan Chapter, Southfield, MI, USA.
FIR - El-Baalbaki, Ghassan
IR  - El-Baalbaki G
IRAD- Universite du Quebec a Montreal, Montreal, Quebec, Canada.
FIR - Hebblethwaite, Shannon
IR  - Hebblethwaite S
IRAD- Concordia University, Montreal, Quebec, Canada.
FIR - Bustamante, Laura
IR  - Bustamante L
IRAD- Concordia University, Montreal, Quebec, Canada.
FIR - Duchek, Delaney
IR  - Duchek D
IRAD- University of Calgary, Alberta, Canada.
FIR - Ellis, Kelsey
IR  - Ellis K
IRAD- University of Calgary, Alberta, Canada.
EDAT- 2020/10/19 06:00
MHDA- 2020/12/30 06:00
PMCR- 2020/10/03
CRDT- 2020/10/18 20:30
PHST- 2020/07/05 00:00 [received]
PHST- 2020/09/21 00:00 [revised]
PHST- 2020/09/30 00:00 [accepted]
PHST- 2020/10/19 06:00 [pubmed]
PHST- 2020/12/30 06:00 [medline]
PHST- 2020/10/18 20:30 [entrez]
PHST- 2020/10/03 00:00 [pmc-release]
AID - S0022-3999(20)30824-2 [pii]
AID - 110262 [pii]
AID - 10.1016/j.jpsychores.2020.110262 [doi]
PST - ppublish
SO  - J Psychosom Res. 2020 Dec;139:110262. doi: 10.1016/j.jpsychores.2020.110262. Epub 
      2020 Oct 3.