PMID- 33071743
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201022
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 14
DP  - 2020
TI  - Altered Cerebellar-Cerebral Circuits in Patients With Type 2 Diabetes Mellitus.
PG  - 571210
LID - 10.3389/fnins.2020.571210 [doi]
LID - 571210
AB  - The role of the cerebellum in type 2 diabetes mellitus (T2DM) has been receiving 
      increased attention. However, the functional connectivity (FC) between the 
      cerebellar subregions and the cerebral cortex has not been investigated in T2DM. 
      Therefore, the purpose of this study was to investigate cerebellar-cerebral FC 
      and the relationship between FC and clinical/cognitive variables in patients with 
      T2DM. A total of 34 patients with T2DM and 30 healthy controls were recruited for 
      this study to receive a neuropsychological assessment and undergo resting-state 
      FC. We selected four subregions of the cerebellum (bilateral lobules IX, right 
      and left Crus I/II, and left lobule VI) as regions of interest (ROIs) to examine 
      the differences in cerebellar-cerebral circuits in patients with T2DM compared to 
      healthy controls. Correlation analysis was performed to examine the relationship 
      between FC and clinical/cognitive variables in the patients. Compared to healthy 
      controls, patients with T2DM showed significantly decreased cerebellar-cerebral 
      FC in the default-mode network (DMN), executive control network (ECN), and 
      visuospatial network (VSN). In the T2DM group, the FC between the left cerebellar 
      lobule VI and the right precuneus was negatively correlated with the Trail Making 
      Test A (TMT-A) score (r = -0.430, P = 0.013), after a Bonferroni correction. In 
      conclusion, patients with T2DM have altered FC between the cerebellar subregions 
      and the cerebral networks involved in cognitive and emotional processing. This 
      suggests that a range of cerebellar-cerebral circuits may be involved in the 
      neuropathology of T2DM cognitive dysfunction.
CI  - Copyright (c) 2020 Zhang, Qi, Gao, Yan, Wang, Tang, Zhe, Cheng, Wang, Xie, Su and 
      Zhang.
FAU - Zhang, Dongsheng
AU  - Zhang D
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Qi, Fei
AU  - Qi F
AD  - Department of Graduate, Xi'an Medical University, Xi'an, China.
FAU - Gao, Jie
AU  - Gao J
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Yan, Xuejiao
AU  - Yan X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Wang, Yarong
AU  - Wang Y
AD  - Department of Diagnostic Radiology, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, China.
FAU - Tang, Min
AU  - Tang M
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Zhe, Xia
AU  - Zhe X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Cheng, Miao
AU  - Cheng M
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Wang, Man
AU  - Wang M
AD  - Department of Graduate, Xi'an Medical University, Xi'an, China.
FAU - Xie, Qingming
AU  - Xie Q
AD  - Department of Graduate, Xi'an Medical University, Xi'an, China.
FAU - Su, Yu
AU  - Su Y
AD  - Department of Graduate, Xi'an Medical University, Xi'an, China.
FAU - Zhang, Xiaoling
AU  - Zhang X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
LA  - eng
PT  - Journal Article
DEP - 20200924
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC7541847
OTO - NOTNLM
OT  - cerebellum
OT  - functional connectivity
OT  - neuroimaging
OT  - resting-state fMRI
OT  - subregion
OT  - type 2 diabetes mellitus
EDAT- 2020/10/20 06:00
MHDA- 2020/10/20 06:01
PMCR- 2020/01/01
CRDT- 2020/10/19 05:54
PHST- 2020/06/10 00:00 [received]
PHST- 2020/08/19 00:00 [accepted]
PHST- 2020/10/19 05:54 [entrez]
PHST- 2020/10/20 06:00 [pubmed]
PHST- 2020/10/20 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2020.571210 [doi]
PST - epublish
SO  - Front Neurosci. 2020 Sep 24;14:571210. doi: 10.3389/fnins.2020.571210. 
      eCollection 2020.